Hydrogels Contact Lenses

Michálek, Jiřı́; Hobzová, Radka; Přádný, Martin; Duskova, Miroslava

doi:10.1007/978-1-4419-5919-5_16

Cited by 17 publications

(18 citation statements)

References 8 publications

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“…They once noticed during their laboratory routine work that materials based on polymerized ethylene glycol methacrylates provided water swollen and clear gels. They realized the major potential of these hydrogels as an option for artificial soft contact lens that did not exist until those days . Immediately, an extensive work on PHEMA polymerization, characterization, swelling, mechanical and phase behavior and biocompatibility had been launched and was carried in 1960's.…”

Section: Introductionmentioning

confidence: 99%

The Manifold Varieties of Poly(2‐Hydroxyethyl Methacrylate) Hydrogels−IPNs

Dušková‐Smrčková

Sadakbayeva

Steinhart

et al. 2017

Macromolecular Symposia

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Summary The interpenetrating network structure was used to control mechanical properties of hydrogels based on poly(2‐hydroxyethyl methacrylate) (PHEMA) (first network (A) or second network (B)) and poly(glycerol methacrylate) (PGMA) (network B). In order to understand the structure, mechanical and swelling properties of sequentially made IPN hydrogels, the swollen PHEMA network microstructure and its formation was investigated by means of swelling and SWAXS experiments. Visually clear and microscopically homogenous hydrogel networks based on poly(2‐hydroxyethyl methacrylate) revealed presence of domains of size 1–10 nm formed during polymerization in the presence of water. The study was carried out to understand conditions under which the hydrophobic interactions are operative and their effect on the microstructure as well as how they change when the double network structure is introduced. The morphologies of network A ranged from homogenous, non‐porous, and optically clear gels, to macroporous gels resulting from phase separation and offering fused‐sphere morphology. A cryogel characterized by large elongated and partially interconnected pores of tens to hundreds micrometers were another object for comparison. In most cases, an increase of tensile moduli and improvement of ultimate tensile properties was achieved. A surprisingly high increase in true strength (by a factor of 10 – 30) was achieved when the macroporous PHEMA network A was reinforced by weak PHEMA or PGMA networks B. All these weakly crosslinked IPN gels were optically clear.

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Section: Introductionmentioning

confidence: 99%

The Manifold Varieties of Poly(2‐Hydroxyethyl Methacrylate) Hydrogels−IPNs

Dušková‐Smrčková

Sadakbayeva

Steinhart

et al. 2017

Macromolecular Symposia

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“…181 While PHEMA hydrogels are stable under physiological conditions, their controlled degradation can be achieved by incorporation of hydrolytically or enzymatically cleavable linkages, such as polycaprolactone, 182, 183 and collagenase-cleavable peptide sequences 184, 185 . Another poly(acrylate) derivative, poly(N-isopropylacrylamide) (PNIPAAm), a thermoresponsive polymer with lower critical solution temperature (LCST) of approximately 32 °C, has been utilized for preparing responsive hydrogels for tissue engineering and drug delivery applications.…”

Section: Materials For Hydrogel Preparationmentioning

confidence: 99%

“…Historically, radical polymerization of hydroxyethyl methacrylate (HEMA) using ethylene dimethacrylate (EDMA) as a crosslinker was extensively studied for commercial-scale manufacturing of flexible contact lenses. 181 A large number of macromolecules, such as HA, 67, 202–204 chitosan, 193, 205 and PEG, 205, 206 are easily functionalized with vinyl end groups and can undergo radical polymerization to form hydrogels in presence of appropriate initiators. For example, Morelli and Chiellini functionalized Ulvan, a sulfated polysaccharide from green seaweed, with methacryloyl groups.…”

Section: Materials Functionalization For Hydrogel Formationmentioning

confidence: 99%

Designing degradable hydrogels for orthogonal control of cell microenvironments

2013

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“…They have received a lot of attention due to their potential for biomedical applications. 2 The key properties for the hydrogels include their hydrophilic structure allowing them to hold large amounts of water and their everlasting service. This three dimensional network is insoluble in water at physiologic pH, ionic strength and temperature.…”

Section: Introductionmentioning

confidence: 99%

“…Close attention should be paid to the physical interactions between the gels as this plays an important role. 2 The properties of the polymer used and the density of network joints have an effect on the hydrogel's formation and behaviour. Hydrogels in equilibrium or in their swollen state contain a large amount of water.…”

Section: Introductionmentioning

confidence: 99%

Fabrication and Characterizations of Hydrogels for Cartilage Repair

Kaur

Khaghani

Oluwadamilola

et al. 2017

ATROA

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Articular cartilage is a vascular tissue with limited repair capabilities, leaving an afflicted person in extreme pain. The tissue experiences numerous forces throughout its lifetime. This study focuses on development of a novel hydrogel composed of chitosan and β-glycerophosphate for articular cartilage repair. The aim of this study was to investigate the mechanical properties and swelling behaviour of a novel hydrogel composed of chitosan and β-glycerophosphate for cartilage repair. The mechanical properties were measured for compression forces. Mach-1 mechanical testing system was used to obtain storage and loss modulus for each hydrogel sample to achieve viscoelastic properties of fabricated hydrogels. Two swelling tests were carried out to compare water retaining capabilities of the samples. The hydrogel samples were made of five different concentrations of β-glycerophosphate cross-linked with chitosan. Each sample with different β-glycerophosphate concentration underwent sinusoidal compression forces at three different frequencies -0.1Hz, 0.316Hz and 1Hz. The result of mechanical testing was obtained as storage and loss modulus. Storage modulus represents the elastic component and loss modulus represents the viscosity of the samples. The results obtained for 1Hz were of interest because the knee experiences frequency of 1Hz during walking. Keywords

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Hydrogels Contact Lenses

Cited by 17 publications

References 8 publications

The Manifold Varieties of Poly(2‐Hydroxyethyl Methacrylate) Hydrogels−IPNs

The Manifold Varieties of Poly(2‐Hydroxyethyl Methacrylate) Hydrogels−IPNs

Designing degradable hydrogels for orthogonal control of cell microenvironments

Fabrication and Characterizations of Hydrogels for Cartilage Repair

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