Hydrogels based on ozonated cassava starch: Effect of ozone processing and gelatinization conditions on enhancing 3D-printing applications

Maniglia, Bianca Chieregato; Lima, Dâmaris Carvalho; Matta, Manoel Divino da; Le-Bail, Patricia; Le‐Bail, Alain; Augusto, Pedro Esteves Duarte

doi:10.1016/j.ijbiomac.2019.07.124

Cited by 83 publications

(33 citation statements)

References 37 publications

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“…Mass fraction of biomass was limited to 0.10 because the suspensions acquired a paste‐like appearance above this value, which would impair their mixing properties and the homogeneity of the treatments during the further conversion process. This combination of conditions resulted in 36 different acid slurries that were used to perform the thermophysical properties measurements at subgelatinization temperatures 23 …”

Section: Methodsmentioning

confidence: 99%

Thermophysical properties of dilute acid slurries of cassava bagasse as a function of biomass loading, acid concentration, and temperature

Polachini

Mulet

Cárcel

et al. 2020

Env Prog and Sustain Energy

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For suitable design of equipment and process optimization, the determination of thermophysical properties of the raw materials is necessary. Therefore, this work was aimed at determining and modeling the density, specific heat, thermal diffusivity, and thermal conductivity of acid slurries of cassava bagasse used during its conversion into bioethanol. Experimental measurements were carried out in slurries with different mass fractions of cassava bagasse (0.00 to 0.10) and phosphoric acid (0.00 to 0.10) at temperatures from 278.13 to 318.13 K. Results obtained show that density varied from 986.5 to 1,029.3 kg∙m−3, specific heat from 3,830.0 to 4,142.6 J∙kg−1∙K−1, thermal diffusivity from 0.9624 × 10−7 to 1.5249 × 10−7 m2∙s−1 and thermal conductivity from 0.3825 to 0.6212 W∙m−1∙K−1. While density increased with increasing solids and acid content at decreasing temperature, the thermal properties decreased at higher solids and acid content and increased when heating the slurries. The values were well‐fitted to polynomial models with good accuracy (R2 > 0.921 and MRE < 1.75%), allowing the application of the models to obtain reliable and ready‐to‐use data for cassava bagasse processing. Thus, the data reported in this study can be used for designing and managing momentum, heat and mass transfer processes for enhancing bioethanol production from cassava bagasse.

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Section: Methodsmentioning

confidence: 99%

Thermophysical properties of dilute acid slurries of cassava bagasse as a function of biomass loading, acid concentration, and temperature

Polachini

Mulet

Cárcel

et al. 2020

Env Prog and Sustain Energy

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“…Hydrogel systems of native starch in water and ethanol are also known with reported swelling capacity values exceeding 400% [37]. Most recently, hydrogel systems based on ozonated cassava starch were achieved with higher functionality and improved gel strength [38]. Ozone-modified natural hydrogels are considered as an emerging technology that is environmentally friendly with new applications in 3D printing and food.…”

Section: Single-component Hydrogelsmentioning

confidence: 99%

A Review on the Design and Hydration Properties of Natural Polymer-Based Hydrogels

2021

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Hydrogels are hydrophilic 3D networks that are able to ingest large amounts of water or biological fluids, and are potential candidates for biosensors, drug delivery vectors, energy harvester devices, and carriers or matrices for cells in tissue engineering. Natural polymers, e.g., cellulose, chitosan and starch, have excellent properties that afford fabrication of advanced hydrogel materials for biomedical applications: biodegradability, biocompatibility, non-toxicity, hydrophilicity, thermal and chemical stability, and the high capacity for swelling induced by facile synthetic modification, among other physicochemical properties. Hydrogels require variable time to reach an equilibrium swelling due to the variable diffusion rates of water sorption, capillary action, and other modalities. In this study, the nature, transport kinetics, and the role of water in the formation and structural stability of various types of hydrogels comprised of natural polymers are reviewed. Since water is an integral part of hydrogels that constitute a substantive portion of its composition, there is a need to obtain an improved understanding of the role of hydration in the structure, degree of swelling and the mechanical stability of such biomaterial hydrogels. The capacity of the polymer chains to swell in an aqueous solvent can be expressed by the rubber elasticity theory and other thermodynamic contributions; whereas the rate of water diffusion can be driven either by concentration gradient or chemical potential. An overview of fabrication strategies for various types of hydrogels is presented as well as their responsiveness to external stimuli, along with their potential utility in diverse and novel applications. This review aims to shed light on the role of hydration to the structure and function of hydrogels. In turn, this review will further contribute to the development of advanced materials, such as “injectable hydrogels” and super-adsorbents for applications in the field of environmental science and biomedicine.

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“…Furthermore, starch is chemically versatile (depending on the source) and can be modified to obtain high quality mechanical and rheological properties [10]. In food manufacturing studies, starch has been shown to be a suitable polymer for extrusion-based 3D printing, providing good printability [11][12][13][14]. Other studies also have reported that the addition of starch in alginate-based 3D systems improved the performance and quality of the final products.…”

Section: Introductionmentioning

confidence: 99%

Effects of Starch Incorporation on the Physicochemical Properties and Release Kinetics of Alginate-Based 3D Hydrogel Patches for Topical Delivery

et al. 2020

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The development of printable hydrogel inks for extrusion-based 3D printing is opening new possibilities to the production of new and/or improved pharmaceutical forms, specifically for topical application. Alginate and starch are natural polysaccharides that have been extensively exploited due to their biocompatibility, biodegradability, viscosity properties, low toxicity, and relatively low cost. This research work aimed to study the physicochemical and release kinetic effects of starch incorporation in alginate-based 3D hydrogel patches for topical delivery using a quality by design approach. The incorporation of a pregelatinized starch is also proposed as a way to improve the properties of the drug delivery system while maintaining the desired quality characteristics. Critical material attributes and process parameters were identified, and the sensitivity and adequacy of each parameter were statistically analyzed. The impact of alginate, starch, and CaCl2·2H2O amounts on relevant quality attributes was estimated crosswise. The amount of starch revealed a synergetic impact on porosity (p = 0.0021). An evident increase in the size and quantity of open pores were detected in the as printed patches as well as after crosslinking (15.6 ± 5.2 µm). In vitro drug release studies from the optimized alginate-starch 3D hydrogel patch, using the probe Rhodamine B, showed an initial high burst release, followed by a controlled release mechanism. The results obtained also showed that the viscoelastic properties, printing accuracy, gelation time, microstructure, and release rates can be modulated by varying the amount of starch added to the system. Furthermore, these results can be considered an excellent baseline for future drug release modulation strategies.

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Hydrogels based on ozonated cassava starch: Effect of ozone processing and gelatinization conditions on enhancing 3D-printing applications

Cited by 83 publications

References 37 publications

Thermophysical properties of dilute acid slurries of cassava bagasse as a function of biomass loading, acid concentration, and temperature

Thermophysical properties of dilute acid slurries of cassava bagasse as a function of biomass loading, acid concentration, and temperature

A Review on the Design and Hydration Properties of Natural Polymer-Based Hydrogels

Effects of Starch Incorporation on the Physicochemical Properties and Release Kinetics of Alginate-Based 3D Hydrogel Patches for Topical Delivery

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