Hydrogels As drug-delivery Platforms: Physicochemical Barriers and Solutions

Alkayyali, Lamees B; Abu-Diak, Osama A.; Andrews, Gavin; Jones, David S.

doi:10.4155/tde.12.48

Cited by 10 publications

(5 citation statements)

References 99 publications

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“…For example, the swelling ratio of hydrogels with 15 wt% acrylic acid and 0.1 wt% crosslinker MBAA was ≈293%, which was significantly higher than that of the other P(AA‐ co ‐HEMA) hydrogels. As the mechanical strength of swollen hydrogels with a high swelling ratio could be compromised, [ 26 ] hydrogels composed of MBAA at 0.25 wt%, which yielded a medium swelling degree, were used in the subsequent studies.…”

Section: Resultsmentioning

confidence: 99%

Interpenetrating Polymer Network Hydrogels Formed Using Antibiotics as a Dynamic Crosslinker for Treatment of Infected Wounds

Gan

Jiang

et al. 2022

Adv Healthcare Materials

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Antibacterial hydrogels, particularly antibiotic-loaded hydrogels, are promising wound dressing materials for treatment of bacteria-infected wound. However, it is challenging to achieve sustained release of antibiotics from hydrogels through physical encapsulation of the antibiotics. Herein, an interpenetrating polymer network P(AA-co-HEMA) Gen hydrogel is reported with double crosslinking formed by free radical polymerization of 2-hydroxyethyl methacrylate (HEMA) and acrylic acid (AA), while using the antibiotic gentamicin (Gen) as the dynamic physical crosslinker. Gentamicin is incorporated into the hydrogel networks via electrostatic interaction between the carboxyl groups of poly(acrylic acid) and the amino groups of gentamicin, which leads to pH-responsive drug release and a significant increase in mechanical strength (i.e., elastic modulus, viscous modulus, and compressive modulus). More importantly, the hydrogels with optimal compositions demonstrate long-lasting antibacterial activity against both Gram-positive bacteria (Staphylococcus aureus) and Gram-negative bacteria (Escherichia coli) over 28 d. The in vivo studies that are conducted in an S. aureus-infected full-thickness skin wound model demonstrate that the double crosslinking hydrogels loaded with gentamicin eliminate bacteria in the wounds more effectively and significantly accelerate wound healing as compared to 3M dressing and the control without any treatment. Taken together, this antibiotic-loaded interpenetrating polymer network hydrogel is potentially a promising wound dressing material for the treatment of bacteria-infected wound.

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Section: Resultsmentioning

confidence: 99%

Interpenetrating Polymer Network Hydrogels Formed Using Antibiotics as a Dynamic Crosslinker for Treatment of Infected Wounds

Gan

Jiang

et al. 2022

Adv Healthcare Materials

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“…In the absence of water, the hydrogel could enter a (b) collapsed state. 206 As such, there are several applications of these hydrogels, in particular, in the biomedical and pharmaceutical sectors, 207 and can be used as contact lenses, membranes for biosensors, linings for artificial hearts, materials for artificial skin, and drug delivery devices. 203,208 Hydrogels are often employed as carriers for controlled release of therapeutic compounds 209,210 because they are hydrophilic and their soft consistency is more similar to natural tissue 211 than any other class of synthetic biomaterials, which contributes to their biocompatibility.…”

Section: Drug Deliverymentioning

confidence: 99%

Towards Smart Drug Delivery: Exploration of a Molecularly Imprinted Polymer Network

Khan¹

2023

Preprint

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The current study explores the concept of Molecular Imprinting Technology (MIT) and evaluates the ability of a molecularly imprinted hydrogel polymer (MIP) to preferentially uptake the template drug propranolol from aqueous solution. The extent of the molecular affinity and recognition was challenged by introducing a secondary competing structure during uptake. The release of propranolol as a response to environmental stimuli was investigated. The MIP was synthesized with copolymers methyl methacrylate (MMA) and N,N-dimethyl acrylamide (DMAA). Morphology was studied by scanning electron microscopy (SEM), ptake, displacement, and release experiments were studied by fluorescence spectroscopy. The SEM studies did not indicate the presence of molecularly imprinted cavities. The MIPs demonstrated preferential uptake in comparison to the non-imprinted (NIP) counterpart. The displacement studies revealed that uptake by the MIP is not very selective. The release studies demonstrated that ropranolol release can be tailored to respond to environmental stimuli such as temperature and, especially, pH.

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“…A malignant solid tumor is one of the most difficult tasks for delivery of therapeutic drug concentration, particularly in the organs like the breast and the brain [1][2][3]. The primary treatment for the identified cancers is surgery, which subsequently need chemotherapy to prevent recurrence.…”

Section: Introductionmentioning

confidence: 99%

In vitro and in vivo efficacy of doxorubicin loaded biodegradable semi-interpenetrating hydrogel implants of poly (acrylic acid)/gelatin for post surgical tumor treatment

et al. 2013

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The paper describes the preparation and evaluation of doxorubicin loaded semi-interpenetrating polymeric hydrogel network of polyacrylic acid (PAc) and gelatin (G). Post surgical antitumor efficacy and biodistribution of doxorubicin from the implanted degradable hydrogels was investigated on Ehrlich's ascites tumor model using albino mice. Polycaprolactone diacrylate (PCL-DAr) was employed as a crosslinking agent for PAc chains whereas G was kept free. The effect of crosslinking concentration on various physico-chemical properties such as thermal behavior, swelling, degradation behavior, drug release and polymer-polymer interactions was investigated by various physico-chemical tools. Semi-interpenetrating polymeric networks (IPNs) with 0.2 mol% crosslinking concentration showed degradation within 20 days in phosphate buffer (pH 6.5). To determine the in vivo anticancer efficacy, placebo and drug laden cylindrical implants (65 ± 5 µg/implant of 10 mg) were implanted in tumor cavity post tumor excision. After predetermined time intervals (day 7, 11, 14, 20 and 25), drug biodistribution was assessed in tumor, tumor periphery, residual hydrogel and all vital organs i.e. liver, spleen, kidney, heart, lung and blood (spectrofluorimetrically). The drug distribution study showed the concentration of drug in the tumor, tumor periphery and residual hydrogel decreased with increasing time; on the 7th day, drug concentration was highest while, on the 25th day, it was negligible; however, insignificant quantities of the drug was found in vital organs. Histological examination revealed no sign of tumor recurrence until the 25th day with 100% necrosis and slight inflammation in treated the group. In vivo results established that these biodegradable implants can be utilized as post surgical therapy for solid tumors.

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Hydrogels As drug-delivery Platforms: Physicochemical Barriers and Solutions

Cited by 10 publications

References 99 publications

Interpenetrating Polymer Network Hydrogels Formed Using Antibiotics as a Dynamic Crosslinker for Treatment of Infected Wounds

Interpenetrating Polymer Network Hydrogels Formed Using Antibiotics as a Dynamic Crosslinker for Treatment of Infected Wounds

Towards Smart Drug Delivery: Exploration of a Molecularly Imprinted Polymer Network

In vitro and in vivo efficacy of doxorubicin loaded biodegradable semi-interpenetrating hydrogel implants of poly (acrylic acid)/gelatin for post surgical tumor treatment

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