Hydrogels 2.0: improved properties with nanomaterial composites for biomedical applications

Memić, Adnan; Alhadrami, Hani A.; Hussain, Mohammad Asif; Aldhahri, Musab; Nowaiser, Fozia Al; Al-Hazmi, Faten; Öklü, Rahmi; Khademhosseini, Ali

doi:10.1088/1748-6041/11/1/014104

Cited by 87 publications

(62 citation statements)

References 151 publications

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“…Unlike other minimally invasive delivery approaches that require polymer injection and in situ gelation, gels made using cryopolymerization are able to retain predefined geometries, architecture, and porosity posti-njection [62,63,65,75,76,77,78]. Similarly, physical properties of cryogels were dependent on the fabrication temperature.…”

Section: Discussionmentioning

confidence: 99%

Injectable Hyaluronic Acid-co-Gelatin Cryogels for Tissue-Engineering Applications

et al. 2018

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Polymeric scaffolds such as hydrogels can be engineered to restore, maintain, or improve impaired tissues and organs. However, most hydrogels require surgical implantation that can cause several complications such as infection and damage to adjacent tissues. Therefore, developing minimally invasive strategies is of critical importance for these purposes. Herein, we developed several injectable cryogels made out of hyaluronic acid and gelatin for tissue-engineering applications. The physicochemical properties of hyaluronic acid combined with the intrinsic cell-adhesion properties of gelatin can provide suitable physical support for the attachment, survival, and spreading of cells. The physical characteristics of pure gelatin cryogels, such as mechanics and injectability, were enhanced once copolymerized with hyaluronic acid. Reciprocally, the adhesion of 3T3 cells cultured in hyaluronic acid cryogels was enhanced when formulated with gelatin. Furthermore, cryogels had a minimal effect on bone marrow dendritic cell activation, suggesting their cytocompatibility. Finally, in vitro studies revealed that copolymerizing gelatin with hyaluronic acid did not significantly alter their respective intrinsic biological properties. These findings suggest that hyaluronic acid-co-gelatin cryogels combined the favorable inherent properties of each biopolymer, providing a mechanically robust, cell-responsive, macroporous, and injectable platform for tissue-engineering applications.

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Section: Discussionmentioning

confidence: 99%

Injectable Hyaluronic Acid-co-Gelatin Cryogels for Tissue-Engineering Applications

et al. 2018

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“…In this review, we mainly focus on soft nanoparticles and how they can modulate various properties of natural hydrogels. A number of reviews on the use of hard nanoparticles in tissue engineering and drug delivery have recently been published …”

Section: Nanofunctionalized Hydrogelsmentioning

confidence: 99%

Soft‐Nanoparticle Functionalization of Natural Hydrogels for Tissue Engineering Applications

Elkhoury

Russell

Sánchez-González

et al. 2019

Adv Healthcare Materials

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Tissue engineering has emerged as an important research area that provides numerous research tools for the fabrication of biologically functional constructs that can be used in drug discovery, disease modeling, and the treatment of diseased or injured organs. From a materials point of view, scaffolds have become an important part of tissue engineering activities and are usually used to form an environment supporting cellular growth, differentiation, and maturation. Among various materials used as scaffolds, hydrogels based on natural polymers are considered one of the most suitable groups of materials for creating tissue engineering scaffolds. Natural hydrogels, however, do not always provide the physicochemical and biological characteristics and properties required for optimal cell growth. This review discusses the properties and tissue engineering applications of widely used natural hydrogels. In addition, methods of modulation of their physicochemical and biological properties using soft nanoparticles as fillers or reinforcing agents are presented.

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“…One simple method for accelerating the response dynamics of hydrogels is doping nanoparticles to build a diffusion passage or platform through the cross‐linked polymer networks . For example, the hydrogel composed of polyelectrolyte can possess electro‐sensitive swelling/deswelling or bending/unbending .…”

Section: Strategies For Fabricating Rapid Responsive Hydrogel Networkmentioning

confidence: 99%

Smart hydrogels: Network design and emerging applications

et al. 2018

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Hydrogels are capable of adsorbing large quantities of water due to their hydrophilic three‐dimensional polymeric networks; thus, their physical properties are similar to soft tissues such as cartilage and muscle. Stimuli‐responsive smart hydrogels are particularly interesting because of their ability to respond to various exogenous and/or endogenous stimuli such as pH, thermal, light, magnetism, etc. Because of their versatile and unique properties, smart hydrogels show great potential in controlled drug release, tissue engineering scaffolds, solid/water stabilization, etc., wherein a rapid responsive property and outstanding mechanical properties are highly desired. The degree of responsiveness and mechanical properties of hydrogels are highly dependent on their polymeric network structures. Thus, the network structure design strategies are of great interest and particular importance for various applications. In this paper, we review various network design strategies to build smart hydrogel networks with rapid responsiveness and/or high mechanical properties, as well as the emerging applications of smart hydrogels such as controlled release systems, detection sensors, soft valves, and responsive actuators. The perspectives as well as current challenges facing the applications of such innovative stimuli‐responsive polymeric materials are also addressed.

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Hydrogels 2.0: improved properties with nanomaterial composites for biomedical applications

Cited by 87 publications

References 151 publications

Injectable Hyaluronic Acid-co-Gelatin Cryogels for Tissue-Engineering Applications

Injectable Hyaluronic Acid-co-Gelatin Cryogels for Tissue-Engineering Applications

Soft‐Nanoparticle Functionalization of Natural Hydrogels for Tissue Engineering Applications

Smart hydrogels: Network design and emerging applications

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