Smart hydrogels: Network design and emerging applications

Liu, Zhuang; Wei, Jie; Faraj, Yousef; Ju, Xin; Xie, Rui; Wang, Wei; Chu, Liang‐Yin

doi:10.1002/cjce.23328

Cited by 21 publications

(15 citation statements)

References 80 publications

(209 reference statements)

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“…Among all stimulus‐responsive hydrogels, temperature‐responsive hydrogel capable of changing its physicochemical properties in response to its ambient temperature variation is of particular importance and has been attracting widespread attention 1 . This is because temperature variation is a common environmental stimulus or can be facilely exerted on the hydrogel by heating or cooling.…”

Section: Introductionmentioning

confidence: 99%

“…For these applications, temperature‐responsive hydrogels are expected to respond to temperature variation as fast as possible, along with satisfactory mechanical property. This is because fast response ensures prompt feedback and actuation once the hydrogels undergo temperature variation, while satisfactory mechanical property makes them have excellent deformability for enduring external force 1 …”

Section: Introductionmentioning

confidence: 99%

“…Among all stimulus-responsive hydrogels, temperatureresponsive hydrogel capable of changing its physicochemical properties in response to its ambient temperature variation is of particular importance and has been attracting widespread attention. 1 This is because temperature variation is a common environmental stimulus or can be facilely exerted on the hydrogel by heating or cooling. Accordingly, the smart hydrogel has fascinating application prospect in many fields, such as controlled drug release, 2 'on/off' switch, 3 temperature sensor, 4 temperature-triggered actuator, 5 and so on.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Fabrication of ultrafast temperature‐responsive nanofibrous hydrogel with superelasticity and its 'on–off' switchable drug releasing capacity

Xie

Liu

Zha

2020

J of Applied Polymer Sci

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The temperature‐responsive bulky hydrogel with fast response rate and satisfactory mechanical property has fascinating application potential in many aspects, such as the implantable macroscale controlled drug release carrier for post‐surgical therapy; however, creating such a smart hydrogel was proven extremely challenging. Here a novel type of temperature‐responsive bulky hydrogel with ultrafast response rate and super compressible elasticity was fabricated by the fibrous freeze‐shaping technique using shortened temperature‐responsive polymer based electrospun hollow nanofibers as building blocks, followed by heat treatment for endowing the hydrogel with high stability in water. Because the hydrogel has hierarchical porous structure and its constituent nanofibers have hollow structure, which are beneficial to diffusion of its embodied water during temperature‐induced volume phase transition, its temperature‐response time is less than 30 s. In addition, the hierarchical porous structure benefits dissipation of the compression stress exerted on the hydrogel. Fluorescein isothiocyanate (FITC)‐dextran as a model biomacromolecular drug, was loaded into the shells of the hollow nanofibers during coaxial electrospinning, and the ultimately obtained nanofibrous hydrogel can release its loaded FITC‐dextran in a 'on–off' switchable fashion in response to temperature alternation between 15 and 47°C. Cell cytotoxicity test results demonstrate that the temperature‐responsive nanofibrous hydrogel is biocompatible.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Fabrication of ultrafast temperature‐responsive nanofibrous hydrogel with superelasticity and its 'on–off' switchable drug releasing capacity

Xie

Liu

Zha

2020

J of Applied Polymer Sci

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show abstract

“…

materials with diverse applications in var ious fields due to their tunable chemistry structure and physical properties as well as excellent biocompatibility. [6][7][8][9][10][11] This unprecedented level of control over material properties has driven both med ical and industrial fields into the realm of possibility: controlled drug delivery, [12] chemical sensors, [13] soft actuators or robotics, [14][15][16] or scaffolds for dynamic 3D cell culture. [6][7][8][9][10][11] This unprecedented level of control over material properties has driven both med ical and industrial fields into the realm of possibility: controlled drug delivery, [12] chemical sensors, [13] soft actuators or robotics, [14][15][16] or scaffolds for dynamic 3D cell culture.

…”

mentioning

confidence: 99%

Design and Applications of Photoresponsive Hydrogels

2019

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materials with diverse applications in var ious fields due to their tunable chemistry structure and physical properties as well as excellent biocompatibility. [2][3][4][5] Hydrogel research has evolved from static mate rials to smart ones, whose structures and property show responsiveness to external stimuli, including temperature, pH, light, electric or magnetic fields, and the pres ence of enzymes or ion concentrations. [6][7][8][9][10][11] This unprecedented level of control over material properties has driven both med ical and industrial fields into the realm of possibility: controlled drug delivery, [12] chemical sensors, [13] soft actuators or robotics, [14][15][16] or scaffolds for dynamic 3D cell culture. [17] Photoresponsiveness is attractive due to the inherent advan tages of light as stimulus. Light is non invasive and allows remote manipulation of materials without requiring additional reagents, thus, with limited byproducts. Modulation of irradiation parameters, such as light intensity and irradiation time, permits the pre cise control of irradiation dosage, thereby, the degree of photo reactions. Spatial control can be achieved in both 2D and 3D, and temporal control is possible by simply turning the respec tive light source on or off. Wavelengthselective photo chemical reactions can be used for orthogonal photomediation of hydrogel properties. [18] Photoresponsive hydrogels, as externally tunable materials, strongly contribute to the field of soft smart materials in regard to the abovementioned applications. [19] In this review, we elaborate on the design and the emerging appli cations of photoresponsive hydrogels. A comprehensive review about utilizing light for the formation of hydrogels is given by Mi and coworkers. [20] First, we discuss responsive modes and photochemical mechanisms of photoresponsive hydrogels. Fol lowing this, we highlight their applications for dynamic cell environments, smart biointerfaces, controlled drug delivery, photodriven actuators, and lighthealing materials. The review concludes with an outlook on the challenges and potential future approaches for photo responsive hydrogels. Light as Stimulus for Hydrogels Macroscopic Hydrogel PhotoresponsesThe interaction of light with photoresponsive hydrogels can result in different responses, some of which are observable with the bare eye. Those include hydrogel formation or degradation, network contraction or expansion, and chemical modifications in the network, which then have an immediate consequence on Hydrogels are the most relevant biochemical scaffold due to their tunable properties, inherent biocompatibility, and similarity with tissue and cell environments. Over the past decade, hydrogels have developed from static materials to "smart" responsive materials adapting to various stimuli, such as pH, temperature, chemical, electrical, or light. Light stimulation is particularly interesting for many applications because of the capability of contact-free remote manipulation of biomaterial properties and inherent spatial and t...

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“…Y. Wang et al review the development of multivariate statistics process monitoring algorithms from 2008–2017 and also introduce some promising directions. The developments of model and experiments on a novel solar steam generation system are comprehensively summarized in Xu et al Liu et al review various network design strategies to build smart hydrogel and its emerging applications . X. Wang et al discuss recent progresses made by their laboratory and existing challenges in chemical process optimization .…”

mentioning

confidence: 99%

Special series: Voices from China

Wang

2018

Can J Chem Eng

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Smart hydrogels: Network design and emerging applications

Cited by 21 publications

References 80 publications

Fabrication of ultrafast temperature‐responsive nanofibrous hydrogel with superelasticity and its 'on–off' switchable drug releasing capacity

Fabrication of ultrafast temperature‐responsive nanofibrous hydrogel with superelasticity and its 'on–off' switchable drug releasing capacity

Design and Applications of Photoresponsive Hydrogels

Special series: Voices from China

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