Hydrogel wound dressings for bioactive treatment of acute and chronic wounds

Koehler, Julia; Brandl, Fabian; Goepferich, Achim

doi:10.1016/j.eurpolymj.2017.12.046

Cited by 502 publications

(353 citation statements)

References 128 publications

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“…Hydrogel‐based wound treatments provide many benefits for wound healing, primarily in terms of wound hydration . Due to this advantage, a number of small molecule RSNOs encapsulated in hydrogels have been developed and evaluated for wound healing benefits.…”

Section: Exogenous Nitric Oxide For Chronic Wound Therapymentioning

confidence: 99%

Nitric Oxide Therapy for Diabetic Wound Healing

Malone-Povolny

Maloney

Schoenfisch

2019

Adv Healthcare Materials

317

236

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Nitric oxide (NO) represents a potential wound therapeutic agent due to its ability to regulate inflammation and eradicate bacterial infections. Two broad strategies exist to utilize NO for wound healing; liberating NO from endogenous reservoirs, and supplementing NO from exogenous sources. This progress report examines the efficacy of a variety of NO‐based methods to improve wound outcomes, with particular attention given to diabetes‐associated chronic wounds.

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Section: Exogenous Nitric Oxide For Chronic Wound Therapymentioning

confidence: 99%

Nitric Oxide Therapy for Diabetic Wound Healing

Malone-Povolny

Maloney

Schoenfisch

2019

Adv Healthcare Materials

317

236

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“…Specifically, skin damages pose serious health risk to the human body, because body fluid retention and protection against exogenous pathogens both depend on the integrity of the skin function. To achieve rapid recovery, the spontaneous healing process begins nearly instantaneous at the wound interface . Platelet aggregation and the formation of fibrin clots stop blood flow within several minutes ( Figure a‐I).…”

Section: Biomedical Applications Of Polysaccharides and Polysaccharidmentioning

confidence: 99%

“…a) Schematic illustration of the healing process, including I) hemostasis and coagulation, II) inflammation, III) proliferation, and IV) remodeling. Reproduced with permission . Copyright 2018, Elsevier B.V. b) The area of wound healing after treating by the ion crosslinked hydrogels, nonionic crosslinked hydrogels, and petrolatum gauze group at different times.…”

Section: Biomedical Applications Of Polysaccharides and Polysaccharidmentioning

confidence: 99%

Recent Progress of Polysaccharide‐Based Hydrogel Interfaces for Wound Healing and Tissue Engineering

Zhu

Mao

Cheng

et al. 2019

Adv Materials Inter

268

142

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Polysaccharide is an abundant and reproducible natural material that is biocompatible and biodegradable. Polysaccharide and its derivatives also possess distinctive properties such as hydrophilicity, mechanical stability, as well as tunable functionality. Polysaccharide‐based hydrogels can be constructed via the physical and/or chemical crosslinking of polysaccharide derivatives with different functional molecules, as porous network structures or nanofibrillar structures. This review discusses the biomedical applications of polysaccharide‐based hydrogels containing native polysaccharides, polysaccharide derivatives, and polysaccharide‐composite hydrogels. Recent works on the fabrication, physical properties, advanced engineering, biomedical applications of cellulose‐, chitosan‐, alginate‐, and starch‐based hydrogels are also elaborated. Such porous swelling scaffolds exhibit great advantages at the interface of a negative pressure system such as wound dressing. In addition, the authors also discuss and summarize the exemplary research works of these hydrogels in the applications of drug release, wound dressing, and tissue engineering. Finally, challenges and future perspectives about the development of polysaccharide‐based hydrogels are discussed.

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“…Among them, ionic cross‐linking is the most widely used process to obtain alginate hydrogels. It can be performed by a combination between an aqueous solution of sodium alginate and a solution of bivalent cations . The cation Ca 2+ is a well‐established cross‐linker, resulting in calcium alginate hydrogels.…”

Section: Introductionmentioning

confidence: 99%

“…It can be performed by a combination between an aqueous solution of sodium alginate and a solution of bivalent cations. 20,25,26 The cation Ca 2+ is a well-established cross-linker, resulting in calcium alginate hydrogels. Calcium alginate gels are nontoxic and biocompatible; hence, they can be used in pharmaceutic, cosmetic, and food applications.…”

Section: Introductionmentioning

confidence: 99%

Alginate hydrogels incorporating neomycin or propolis as potential dressings for diabetic ulcers: Structure, swelling, and antimicrobial barrier properties

Candido

Conceição

Moreira

et al. 2019

Polymers for Advanced Techs

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Alginate hydrogels have many attractive characteristics for potential use as wound dressing materials. However, they are not considered to possess any intrinsic activity against microbial infection, often present in neuropathic wounds. To overcome this, the effect of incorporating neomycin or propolis in alginate hydrogels was investigated, both by direct blending alone and also by further addition of loaded alginate microparticles prepared by the extrusion dripping method. The morphological, microstructural, thermal, mechanical, and swelling properties of each film were evaluated, as well as particle size distribution and antimicrobial penetration analysis. Microparticle size was considered suitable for drug delivery applications and incorporation in hydrogel films. The presence of neomycin and propolis, in both blended and microparticle form, interfered with film properties leading to hydrogels with different characteristics. All samples showed swelling degrees up to 100% and mechanical and thermal properties suitable for application as wound dressings. In addition, all samples acted as barriers to microbial penetration.

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Hydrogel wound dressings for bioactive treatment of acute and chronic wounds

Cited by 502 publications

References 128 publications

Nitric Oxide Therapy for Diabetic Wound Healing

Nitric Oxide Therapy for Diabetic Wound Healing

Recent Progress of Polysaccharide‐Based Hydrogel Interfaces for Wound Healing and Tissue Engineering

Alginate hydrogels incorporating neomycin or propolis as potential dressings for diabetic ulcers: Structure, swelling, and antimicrobial barrier properties

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