Hydrogel-thickened nanoemulsions based on essential oils for topical delivery of psoralen: Permeation and stability studies

Barradas, Thaís Nogueira; Senna, Juliana Perdiz; Cardoso, Stephani Araujo; Nicoli, Sara; Santi, Patrizia; Rossi, Francesca; Silva, Káttya Gyselle de Holanda e; Mansur, Cláudia R. E.

doi:10.1016/j.ejpb.2016.11.018

Cited by 61 publications

(22 citation statements)

References 57 publications

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“…Here, all the prepared EPR nanoemulgels exhibit non-Newtonian shear-shinning behavior, which originated from the broken of entanglements or physical nodes that are responsible for raising the viscosity of nanoemulgel. Then, the polymer chains realign in the direction of the applied strain, thus lead to the lowering of viscosity (Barradas et al., 2017).…”

Section: Resultsmentioning

confidence: 99%

Eprinomectin nanoemulgel for transdermal delivery against endoparasites and ectoparasites: preparation, in vitro and in vivo evaluation

Mao

Chen

et al. 2019

Drug Delivery

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Nanoemulgels are composed of O/W nanoemulsion and hydrogels and are considered as ideal carriers for the transdermal drug delivery because these have high affinity to load hydrophobic drugs. The stable formulation of eprinomectin (EPR) is very challenging because of it is high hydrophobic nature. In this work, we have prepared EPR loaded nanoemulgel for the treatment of endo-and ectoparasites. The surface morphology of optimized formulations was characterized by scanning electron microscopy. Additionally, skin permeability and irritation tests were conducted for in vitro safety and in vivo skin retention and pearmeation test of EPR nanoemulgel were conducted for efficacy study. Obtained results indicated that the optimized formulation had good shear-thinning behavior, bioadhesiveness properties, and are nanosized droplets with porous internal structure, which are required for topical application. Furthermore, this formulation has showed good skin permeability in comparison to suspension and has no skin irritating property. Overall, the obtained results proved that nanoemulgel is a promising carrier for transdermal drug delivery and EPR nanoemulgel is a promising formulation for the treatment of endo-and ectoparasites.

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Section: Resultsmentioning

confidence: 99%

Eprinomectin nanoemulgel for transdermal delivery against endoparasites and ectoparasites: preparation, in vitro and in vivo evaluation

Mao

Chen

et al. 2019

Drug Delivery

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“…Low viscosity of NEs that might be unsuitable for topical application could be overcome by hydrogel-thickened NEs using thickening polymer, e.g. CS (Barradas et al 2017). Challenges and future prospects of NEs as a drug delivery system were presented by Yukuyama et al (2017).…”

Section: Transdermal Nanoemulsion Formulationsmentioning

confidence: 99%

Bio-Based Nanoemulsion Formulations Applicable in Agriculture, Medicine, and Food Industry

Jampílek

Kráľová

Campos

et al. 2019

Nanotechnology in the Life Sciences

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Nanotechnology providing "a new dimension" accompanied with new properties conferred to many current materials is widely used for production of a new generation of agrochemicals, in medicine it enables improved drug bioavailability, reducing undesirable side effects, minimizing non-specific uptake and specific targeting to certain target cells, while in food industry it has great importance in food protection and biofortification of food with valuable ingredients. In biobased nanoemulsions belonging to lipid nanocarriers plant oils used for oil phase, emulsifiers, biosurfactants, cosurfactants, targeting ligands on the surface of nanoemulsion (e.g., folate) or encapsulated active ingredients are of natural origin. The biocomponents of such nanoemulsions show low toxicity to living organisms, could protect encapsulated compounds for degradation, ensure their sustainable release and reduce the amount of active ingredient necessary for required effect. This chapter presents a comprehensive current overview of recent findings in the field of nanoemulsions and their utilization in agriculture and food industry, with the main emphasis on formulations encapsulating essential oils or plant extracts suitable as effective pesticide preparations as well as medicinal applications of bio-based nanoemulsions, where attention is paid to transdermal nanoemulsion formulations, the use of nanoemulsions in cancer therapy and for pulmonary and ocular drug delivery. Nanoemulsions formulated with natural emulsifiers, biosurfactants and biopolymers are presented and bio-based nanoemulsions of essential oils and their constituents as well as nanoemulsions with encapsulated vitamins, fatty acids and some bioactive compounds are discussed. Applications of nanoemulsions in edible coatings are outlined as well.

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“…Various topical NE-based formulations of similar essential oils, such as tea tree oil, have been investigated for biological evaluation [20][21][22][23]. Topical NEs of other essential oils, such as eucalyptus essential oil, celery essential oil, psoralen, lemongrass essential oil, and babchi essential oil, have also been studied in the literature [12,[24][25][26][27][28]. To the best of our knowledge, NEO has not been formulated in any topical NE formulation and there is no marketed product of NEO for effective acne treatment.…”

Section: Introductionmentioning

confidence: 99%

Nanoemulsification Improves the Pharmaceutical Properties and Bioactivities of Niaouli Essential Oil (Melaleuca quinquenervia L.)

Shakeel¹,

Salem‐Bekhit²,

Haq³

et al. 2021

Molecules

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We develop a suitable delivery system for niaouli essential oil (NEO) using a nanoemulsification method for acne vulgaris. Prepared nanoemulsions (NEs) were characterized for droplet dimension, rheology, surface charge, and stability. The ability of NEO formulations against Propionibacterium acnes and Staphylococcus epidermidis was investigated and all formulations showed antiacne potential in vitro. Ex vivo permeation studies indicated significant improvement in drug permeations and steady state flux of all NEO-NEs compared to the neat NEO (p < 0.05). On the basis of the studied pharmaceutical parameters, enhanced ex vivo skin permeation, and marked effect on acne pathogens, formulation NEO-NE4 was found to be the best (oil (NEO; 10% v/v); Kolliphor EL (9.25% v/v), Carbitol (27.75% v/v), and water (53% v/v)). Concisely, the in vitro and ex vivo results revealed that nanoemulsification improved the delivery as well as bioactivities of NEO significantly.

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Hydrogel-thickened nanoemulsions based on essential oils for topical delivery of psoralen: Permeation and stability studies

Cited by 61 publications

References 57 publications

Eprinomectin nanoemulgel for transdermal delivery against endoparasites and ectoparasites: preparation, in vitro and in vivo evaluation

Eprinomectin nanoemulgel for transdermal delivery against endoparasites and ectoparasites: preparation, in vitro and in vivo evaluation

Bio-Based Nanoemulsion Formulations Applicable in Agriculture, Medicine, and Food Industry

Nanoemulsification Improves the Pharmaceutical Properties and Bioactivities of Niaouli Essential Oil (Melaleuca quinquenervia L.)

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