Hydrogel-thickened nanoemulsion system for topical delivery of lipophilic drugs

Mou, Dongsheng; Chen, Huabing; Du, Danrong; Mao, Chengwen; Wan, Jing; Xu, Huibi; Yang, Xiangliang

doi:10.1016/j.ijpharm.2007.11.051

Cited by 181 publications

(98 citation statements)

References 29 publications

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“…This suggested that a relatively large amount of drug was deposited on the SC, probably due to the high affinity between CP934 and the SC. 35 The TER and CIT amounts decreased in the order NG1 . NG2 .…”

Section: Figurementioning

confidence: 95%

Effects of Carbopol<sup>®</sup> 934 proportion on nanoemulsion gel for topical and transdermal drug delivery: a skin permeation study

Zheng¹,

Ouyang²,

Wei³

et al. 2016

IJN

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Section: Figurementioning

confidence: 95%

Effects of Carbopol<sup>®</sup> 934 proportion on nanoemulsion gel for topical and transdermal drug delivery: a skin permeation study

Zheng¹,

Ouyang²,

Wei³

et al. 2016

IJN

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“…Non-ionic surfactants such as Tween 80 increase emulsion stability by forming inter surfaces film with high elasticity to keep distance between particles (Danov, et al, 2001). Co-surfactant will assist dispersion and 1041 dissolution of -carotene by connecting surfactant molecules to support stability of reduction interface tension (Mou, et al, 2008).…”

mentioning

confidence: 99%

SNEDDS (SELF-NANOEMULSIFYING DRUG DELIVERY SYSTEM) FORMULATION OF -CAROTENE IN OLIVE OIL (Olea europaea)

Wulandari¹,

Alverina²,

Martien³

2016

IJAR

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“…Self nanoemulsifying drug delivery systems (SNEDDS) are isotropic mixtures of drug, lipids and surfactants, usually with one or more hydrophilic co-solvents or co-emulsifiers that form fine oil in water nanoemulsions upon mild agitation in an aqueous medium with a droplet sizes ranging 20-200 nm (Mou et al, 2008;Porter et al, 2008). In the gastrointestinal tract environment (fluids 100 and motility) this systems spontaneously emulsify (Nazzal et al, 2002;Devani et al, 2004;Patel et al, 2007).…”

mentioning

confidence: 99%

Design and optimization of self-nanoemulsifying drug delivery systems (SNEDDS) for enhanced dissolution of gemfibrozil

Villar

Naveros

Campmany

et al. 2012

International Journal of Pharmaceutics

140

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Self nanoemulsifying drug delivery systems of gemfibrozil were developed under Quality by Design approach for improvement of dissolution and oral absorption. Preliminary screening was performed to select proper components combination. Box-Behnken experimental design was employed as statistical tool to optimize the formulation variables, X1 (Cremophor® EL), X2 (Capmul® MCM -C8), and X3 (lemon essential oil). Systems were assessed for visual characteristics (emulsification efficacy), turbidity, droplet size, polydispersity index and drug release. Different pH media were also assayed for optimization. Following optimization, the values of formulation components (X1, X2, and X3) were 32. 43%, 29.73% and 21.62 %, respectively (16.22% of gemfibrozil). Transmission electron microscopy demonstrated spherical droplet morphology. SNEEDS release study was compared to commercial tablets. Optimized SNEDDS formulation of gemfibrozil showed a significant increase in dissolution rate compared to conventional tablets. Both formulations followed Weibull mathematical model release with a significant difference in td parameter in favour of the SNEDDS. Equally amodelistic parameters were calculated being the dissolution efficiency significantly higher for SNEDDS, confirming that the developed SNEDDS formulation was superior to commercial formulation with respect to in vitro dissolution profile. This paper provides an overview of the SNEDDS of the gemfibrozil as a promising alternative to improve oral absorption. She is an expert in nanotechnology (colloids and nanoparticles) with a wide experience. She has extensive curriculum of published paper about this subject Jose Luis Arias Mediano Ph. D. Professor reseracher, Pharmacy and Pharmaceutical Technology , University of Granada jlarias@ugr.es He is an expert in nanotechnology (colloids and nanoparticles) with a wide experience in this type of investigation. Also is reviewer in specialized pharmaceutical journal. He is an expert in nanotechnology (colloids and nanoparticles) with a wide experience in this type of investigation. Also is reviewer of Pharmaceutical science journals. IJP AUTHOR CHECKLISTDear Author, It frequently happens that on receipt of an article for publication, we find that certain elements of the manuscript, or related information, is missing. This is regrettable of course since it means there will be a delay in processing the article while we obtain the missing details.In order to avoid such delays in the publication of your article, if accepted, could you please run through the list of items below and make sure you have completed the items. Overall Manuscript Electronic artwork format? ---------------------------------------------------TIFF

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Hydrogel-thickened nanoemulsion system for topical delivery of lipophilic drugs

Cited by 181 publications

References 29 publications

Effects of Carbopol<sup>®</sup> 934 proportion on nanoemulsion gel for topical and transdermal drug delivery: a skin permeation study

Effects of Carbopol<sup>®</sup> 934 proportion on nanoemulsion gel for topical and transdermal drug delivery: a skin permeation study

SNEDDS (SELF-NANOEMULSIFYING DRUG DELIVERY SYSTEM) FORMULATION OF -CAROTENE IN OLIVE OIL (Olea europaea)

Design and optimization of self-nanoemulsifying drug delivery systems (SNEDDS) for enhanced dissolution of gemfibrozil

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Hydrogel-thickened nanoemulsion system for topical delivery of lipophilic drugs

Cited by 181 publications

References 29 publications

Effects of Carbopol<sup>&reg;</sup> 934 proportion on nanoemulsion gel for topical and transdermal drug delivery: a skin permeation study

Effects of Carbopol<sup>&reg;</sup> 934 proportion on nanoemulsion gel for topical and transdermal drug delivery: a skin permeation study

SNEDDS (SELF-NANOEMULSIFYING DRUG DELIVERY SYSTEM) FORMULATION OF -CAROTENE IN OLIVE OIL (Olea europaea)

Design and optimization of self-nanoemulsifying drug delivery systems (SNEDDS) for enhanced dissolution of gemfibrozil

Contact Info

Product

Resources

About

Effects of Carbopol<sup>®</sup> 934 proportion on nanoemulsion gel for topical and transdermal drug delivery: a skin permeation study

Effects of Carbopol<sup>®</sup> 934 proportion on nanoemulsion gel for topical and transdermal drug delivery: a skin permeation study