Hydrogel prepared by 3D printing technology and its applications in the medical field

Cheng, Liang; Xu, Na; Zong, Qida; Yu, Jia; Zhang, Peng

doi:10.1016/j.colcom.2021.100498

Cited by 49 publications

(24 citation statements)

References 127 publications

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“…Compared with other micro‐scale manufacturing methods, 3D printing technology can realize the complex geometry and multifunctional performance of MNs. [ 59 ] However, due to the limitations of material properties and printing capabilities, 3D‐printed MNs still have bottlenecks in achieving the mechanical properties required for various clinical applications. [ 60 ] The extraction volume and stability of biomarkers are critical to the detection accuracy of the extracted ISF.…”

Section: Functionalized Mnsmentioning

confidence: 99%

Microneedle‐Based Technology: Toward Minimally Invasive Disease Diagnostics

Zhang

et al. 2022

Adv Materials Technologies

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biomarkers by extracting ISF and can also be used as electrodes to detect blood glucose, tumor biomarkers and pH value in body fluids in real time.MNs are composed of a series of microsized needles and are widely used in transdermal drug delivery systems (TDDS) due to the advantages of high efficiency, safety and convenience. In recent years, MNs have been frequently used to deliver drugs, genes, proteins, RNAs and vaccines, and have achieved amazing therapeutic effects. [5] Additionally, MNs are also widely studied for blood sampling, signal monitoring and biosensor. [6] The new coronavirus COVID-19 is raging around the world. Researchers had developed a fingertip-sized MNs to deliver the vaccine. The results showed that the vaccine could produce SARS-CoV-2 specific antibodies in mice that could neutralize the virus. [7] Zhou et al. [8] loaded the anticancer drug curcumin into the MNs, and verified the antitumor effects of MNs in the melanoma model. In addition, MNs had also been used in clinical practice, and researchers had evaluated the efficacy and safety of MNs administration based on the effects of clinical trials. The results indicated that MNs showed similar or more efficient results compared with conventional treatment methods. [9] Interstitial fluid (ISF) is an alternative source to detect traditional biomarkers such as blood and urine. [10] Recently, a new method has emerged, that is, using MNs to extract ISF and analyze biomarkers in ISF. [11] The materials for preparing the MNs are usually metals or polymers. The tips length of MNs is about 50-900 µm, which can penetrate the skin stratum corneum to extract ISF. [12] However, ISF has received limited attentions from researchers due to the difficulty of extracting ISF. It is very necessary to develop a minimally invasive technique to sample ISF for clinical monitoring and diagnosis.ISF can be collected by techniques such as micro dialysis or open flow perfusion, these techniques not only require local anesthesia and professional operations but also take a certain amount of time, and there is a potential risk of infection. [13] It is a promising technique to extract ISF by inserting MNs into skin to form micropores. The average depth of the dermis is generally 500-2000 µm. [14] The tips of MNs are generally short, and they can penetrate the superficial layer of the skin but cannot reach the nerves and blood vessels in the dermis, which can painlessly extract ISF. [15] The biggest challenge of extracting ISF for analysis is insufficient sampling, which greatly limits The traditional way of disease diagnosis is to detect biomarkers in serum, blood, urine, and saliva, but it often faces wound infection and pain, and usually requires professional medical personnel to operate, which is unacceptable for most people. As a result, minimally invasive detection of biomarkers has attracted wide attention and is expected to become a new method for patient monitoring and disease diagnosis. Interstitial fluid (ISF) acts as a medium between cells and the circulatory ...

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Section: Functionalized Mnsmentioning

confidence: 99%

Microneedle‐Based Technology: Toward Minimally Invasive Disease Diagnostics

Zhang

et al. 2022

Adv Materials Technologies

Self Cite

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Section: Introductionmentioning

confidence: 99%

“…As one of the main factors of 3D printing for biomedical applications, printable material must meet requirements such as high biocompatibility, biosafety, and low cytotoxicity. 12,13 As a biocompatible material, hydrogel is a splendid choice to serve as biological 3D printing ink. [14][15][16] Hydrogels with good biosafety, low toxicity, and can maintain a sustained or triggered local drug release are good candidates for drug delivery carriers.…”

Section: Introductionmentioning

confidence: 99%

Recent advances in 3D printing hydrogel for topical drug delivery

Zhang

Wang

2022

MedComm – Biomaterials and Applications

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Polymer hydrogel has been used as a drug delivery carrier for many decades. Recently, the emergence of three‐dimensional (3D) printing technology has opened up a new area for applications of drug delivery based on polymer hydrogel. A series of drug delivery platforms based on 3D printing hydrogel are developed to achieve local delivery of small/large molecule drugs as well as therapeutic cells. Compared with other manufacturing technologies, 3D printing technology can achieve high‐precision personalized manufacturing and complex spatial structure construction, which has a wide application prospect in the biomedical field. In this review, we summarized the recent advances in 3D printed polymer hydrogels as delivery platforms in drug and cell topical delivery. 3D printed drug delivery platform realizes drug delivery and controlled release locally. Meanwhile, precise control and manufacturing also provide conditions for customized drug delivery platforms. Besides this, a complex spatial structure constructed based on 3D printing technology is also conducive to cell proliferation and differentiation, providing a new carrier for tissue engineering and repair. Biomedical applications based on 3D printing technology promote the development of precision medicine and personalized medicine and provide a new direction for further research and application of 3D printing technology.

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“…Additive manufacturing [1] has attracted much attention due to its superiorities in reducing the number of parts and manufacturing process, improving material utilization ratio, and manufacturing complex geometry [2][3][4]. 3D printing technology is the pillar of the fourth industrial revolution and is widely used in aerospace, automobile, biomedicine, art design, architecture, and other fields [5][6][7][8][9][10][11][12][13]. Three-dimensional printing technology mainly includes fused deposition modeling (FDM), selective laser melting (SLM), stereolithography (SL), and laminated object manufacturing (LOM), among which fused deposition modeling is one of the most widely used [14].…”

Section: Introductionmentioning

confidence: 99%

Shear and Tensile Behaviors of Fiber-Reinforced Resin Matrix Composites Printed by the FDM Technology

et al. 2022

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Resin/fiber composites were prepared by the FDM printing technology. The effects of arrangements, types (carbon, glass, and Kevlar), and volume fraction of fibers on the shear and tensile properties of resin 3D-printed composites are investigated in this paper. The experimental results show that the addition of continuous fibers increases the shear strength and tensile strength of FDM-3D-printed composites, but the strength will not keep increasing with an increase in the fiber content. As the fiber content increases, the print quality decreases, and the porosity between the fibers increases. The enhancement degree of the shear stress of specimens by different fiber types can be classified as follows: glass fiber > carbon fiber > Kevlar fiber. Notch sensitivity is reduced when the 90° arrangement of fibers is added, while the addition of 0° arranged fibers will improve the notch sensitivity of the sample. The research results of this paper have an important guiding significance for selecting fiber types and arrangement mode of notched components in engineering applications.

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Hydrogel prepared by 3D printing technology and its applications in the medical field

Cited by 49 publications

References 127 publications

Microneedle‐Based Technology: Toward Minimally Invasive Disease Diagnostics

Microneedle‐Based Technology: Toward Minimally Invasive Disease Diagnostics

Recent advances in 3D printing hydrogel for topical drug delivery

Shear and Tensile Behaviors of Fiber-Reinforced Resin Matrix Composites Printed by the FDM Technology

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