Hydrogel patch from liquid smoke and vitamin K Collard Greens extract for wound healing applications

Abstract

Wound care by using wound dressing has been evolved available in various physical forms including hydrogels with the highest global use reaching 43%. Nowadays, hydrogels are available at high cost because produced from synthetic materials, so natural materials are needed to obtain antibacterial wound dressing. This study aims to analyze the hydrogel patch PVA/chitosan/starch infused liquid smoke and vitamin K collard greens extract which are antibacterial effects and accelerates wound healing. This study was a laboratory experiment. Collard greens were extracted by using the Direct Solvent Extraction II method. The membrane characteristic tested using SEM test. The parallel streak method (AATCC 147-2004) was used for antibacterial testing. The hydrogel patch application was carried out on 28 male Rattus norvegicus strain wistar rats. They were given incisions wound and treated by a control group and 3 treatment groups and conducted wound healing analysis on the 4th,7th,11th and 14th day observation. The antibacterial test showed the hydrogel patch infused liquid smoke with a concentration of 12% was the optimum concentration inhibiting S. aureus. In conclusion, the hydrogel patch has a smooth and porous surface, can be inhibited the growth of S. aureus, and proven to completely heal the animal wound.

Liquid Smoke and Hydrogel Membrane as Burn Wound Healing Properties

“…This is because P1 has various properties that benefit the reepithelialization process, namely antibacterial, antioxidant and anti-inflammatory. 14,[16][17][18] Wound exudate is a normal component of the wound healing process. Burns usually have excess exudate.…”

“…Hydrogel membrane which has a high absorption capacity with liquid smoke as an antibacterial agent is a suitable combination to heal and prevent wounds from infection. 16,21,22 Bacterial activity in the wound causes delays in wound healing due to the inflammatory response. [23][24][25] In the control group, the results of the lowest reepithelialization length were obtained.…”

“…Wound healing by hydrogel membrane was faster than the control group. 16 Based on the description above, it is interesting to do further research on liquid smoke and hydrogel membrane. Hydrogel membrane combined with liquid smoke will be tested on rat burns to assess the length of reepithelialization which is one of the important histopathological indicators that need to be assessed in wound healing.…”