Hydrogel loaded with self-assembled dextran sulfate-doxorubicin complexes as a delivery system for chemotherapy

Niu, Xiaoyun; Zhang, Zhiling; Zhong, Yinghui

doi:10.1016/j.msec.2017.04.013

Cited by 23 publications

(11 citation statements)

References 15 publications

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“…The technical aspects of DOX release from HGs were examined by a group from Drexel University [232]. In this study, an agarose-based HG was used wherein DOX-dextran sulphate complexes were provided.…”

Section: Injection Of Hydrogelsmentioning

confidence: 99%

Hydrogels as Potential Nano-, Micro- and Macro-Scale Systems for Controlled Drug Delivery

2020

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This review is an extensive evaluation and essential analysis of the design and formation of hydrogels (HGs) for drug delivery. We review the fundamental principles of HGs (their chemical structures, physicochemical properties, synthesis routes, different types, etc.) that influence their biological properties and medical and pharmaceutical applications. Strategies for fabricating HGs with different diameters (macro, micro, and nano) are also presented. The size of biocompatible HG materials determines their potential uses in medicine as drug carriers. Additionally, novel drug delivery methods for enhancing treatment are discussed. A critical review is performed based on the latest literature reports.

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Section: Injection Of Hydrogelsmentioning

confidence: 99%

Hydrogels as Potential Nano-, Micro- and Macro-Scale Systems for Controlled Drug Delivery

2020

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“…A robust injectable thermo-responsive AGR hydrogel incorporating sodium humate and DOX was proposed as a valuable tool for chemo-photothermal treatment of breast cancer [258]. Furthermore, DOX@nanoparticles were encapsulated in AGR injectable hydrogels for sustained local drug delivery (Table 9) [259].…”

Section: Natural Polymersmentioning

confidence: 99%

Injectable Hydrogels for Cancer Therapy over the Last Decade

et al. 2019

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The interest in injectable hydrogels for cancer treatment has been significantly growing over the last decade, due to the availability of a wide range of starting polymer structures with tailored features and high chemical versatility. Many research groups are working on the development of highly engineered injectable delivery vehicle systems suitable for combined chemo-and radio-therapy, as well as thermal and photo-thermal ablation, with the aim of finding out effective solutions to overcome the current obstacles of conventional therapeutic protocols. Within this work, we have reviewed and discussed the most recent injectable hydrogel systems, focusing on the structure and properties of the starting polymers, which are mainly classified into natural or synthetic sources. Moreover, mapping the research landscape of the fabrication strategies, the main outcome of each system is discussed in light of possible clinical applications.

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“…A dextran sulfate (DS)‐based drug delivery system for controlled and sustained release of DOX was developed. This DS‐DOX complexes can be further encapsulated into injectable agarose hydrogels and achieve sustained local delivery of low‐dose DOX against breast cancer (Niu, Zhang, & Zhong, ). With dextran sulfate 15 as the backbone and 5β‐cholanic acid, spherical nanoparticles were developed as carrier for MTX against rheumatoid arthritis (Heo et al, ).…”

Section: Polysaccharidesmentioning

confidence: 99%

Carbohydrate‐based nanomaterials for biomedical applications

Gim

Zhu

Seeberger

et al. 2019

WIREs Nanomed Nanobiotechnol

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Carbohydrates are abundant biomolecules, with a strong tendency to form supramolecular networks. A host of carbohydrate-based nanomaterials have been exploited for biomedical applications. These structures are based on simple monoor disaccharides, as well as on complex, polymeric systems. Chemical modifications serve to tune the shapes and properties of these materials. In particular, carbohydrate-based nanoparticles and nanogels were used for drug delivery, imaging, and tissue engineering applications. Due to the reversible nature of the assembly, often based on a combination of hydrogen bonding and hydrophobic interactions, carbohydrate-based materials are valuable substrates for the creations of responsive systems. Herein, we review the current research on carbohydratebased nanomaterials, with a particular focus on carbohydrate assembly. We will discuss how these systems are formed and how their properties are tuned. Particular emphasis will be placed on the use of carbohydrates for biomedical applications.

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Hydrogel loaded with self-assembled dextran sulfate-doxorubicin complexes as a delivery system for chemotherapy

Cited by 23 publications

References 15 publications

Hydrogels as Potential Nano-, Micro- and Macro-Scale Systems for Controlled Drug Delivery

Hydrogels as Potential Nano-, Micro- and Macro-Scale Systems for Controlled Drug Delivery

Injectable Hydrogels for Cancer Therapy over the Last Decade

Carbohydrate‐based nanomaterials for biomedical applications

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