Hydrogel Dressings

Irmukhametova, Galiya S.; Mun, Grigoriy A.; Khutoryanskiy, Vitaliy V.

doi:10.1002/9781119433316.ch9

Cited by 7 publications

(4 citation statements)

References 119 publications

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“…To mitigate this, a composite structure is formed with antimicrobial agents. In cases of injuries related to illnesses causing a weakened immune system, active antimicrobial pharmaceutical components are typically employed, while ensuring this does not disrupt the wound environment [64].…”

Section: D Bioprinted Wound Dressingsmentioning

confidence: 99%

Advances in Three Dimensional Bioprinting for Wound Healing: A Comprehensive Review

Umur,

Bayrak,

Arslan

et al. 2023

Applied Sciences

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The vulnerability of skin wounds has made efficient wound dressing a challenging issue for decades, seeking to mimic the natural microenvironment of cells to facilitate cell binding, augmentation, and metamorphosis. Many three-dimensional (3D) bioprinted hydrogel-based configurations have been developed using high-tech devices to overcome the limitations of traditional dressing materials. Based on a material perspective, this review examines current state-of-the-art 3D bioprinting for hydrogel-based dressings, including both their advantages and limitations. Accordingly, their potential applications in terms of their performance in vitro and in vivo, as well as their adaptability to clinical settings, were investigated. Moreover, different configurations of 3D bioprinters are discussed. Finally, a roadmap for advancing wound dressings fabricated with 3D bioprinting is presented.

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Section: D Bioprinted Wound Dressingsmentioning

confidence: 99%

Advances in Three Dimensional Bioprinting for Wound Healing: A Comprehensive Review

Umur,

Bayrak,

Arslan

et al. 2023

Applied Sciences

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“…These properties prevent tissue dehydration, and for that reason, hydrogels can be applied in the preparation of dressings for acute/chronic wounds, burns, and also diabetic foot ulcers [37,[105][106][107][108]. Moreover, hydrogels are insoluble, swellable polymers which have a high water content, and they come in the form of an amorphous gel, or as an elastic solid sheet or film [103,109]. This kind of dressings is perfect for supporting autolytic debridement of necrosis and slough by rehydrating dead tissues [110].…”

Section: Hydrogel Dressingsmentioning

confidence: 99%

“…Taking into account the various medical requirements, alginate is applied in disparate derivative materials. Its derivative materials, including wafers [101-104], foams [2,105,106], gauzes [107][108][109], and fibers [110][111][112] are widely used for wound healing [44,113]. Among these, nanofibers and microfibers have their particular interest in clinical applications.…”

Section: Alginate Dressingsmentioning

confidence: 99%

Nanomaterials for Wound Dressings: An Up-to-Date Overview

2020

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As wound healing continues to be a challenge for the medical field, wound management has become an essential factor for healthcare systems. Nanotechnology is a domain that could provide different new approaches concerning regenerative medicine. It is worth mentioning the importance of nanoparticles, which, when embedded in biomaterials, can induce specific properties that make them of interest in applications as materials for wound dressings. In the last years, nano research has taken steps to develop molecular engineering strategies for different self-assembling biocompatible nanoparticles. It is well-known that nanomaterials can improve burn treatment and also the delayed wound healing process. In this review, the first-line of bioactive nanomaterials-based dressing categories frequently applied in clinical practice, including semi-permeable films, semipermeable foam dressings, hydrogel dressings, hydrocolloid dressings, alginate dressings, non-adherent contact layer dressings, and multilayer dressings will be discussed. Additionally, this review will highlight the lack of high-quality evidence and the necessity for future advanced trials because current wound healing therapies generally fail to provide an excellent clinical outcome, either structurally or functionally. The use of nanomaterials in wound management represents a unique tool that can be specifically designed to closely reflect the underlying physiological processes in tissue repair.

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“…30 Previously, a methodology for the synthesis of thiolated organosilica nanoparticles have been developed by Khutoryanskiy et al, via self-condensation of (3mercaptopropyl)trimethoxysilane in dimethyl sulfoxide (DMSO) in the presence of air. 31,32 Due to the presence of thiol groups on their surface, these nanoparticles were demonstrated to be an excellent model of mucoadhesive nanomedicines, 31,33 and were also a very good substrate for further covalent surface functionalization with water-soluble polymers, such as PEG, using thiol−maleimide click reactions. 31,33−36 In this work, we exploit the threading of α-CD on these PEGylated organosilica nanoparticles (sub-100 nm), where the PEG chains are covalently grafted on the surface of the nanoparticles 34 and therefore cannot be displaced through complexation.…”

Section: ■ Introductionmentioning

confidence: 99%

Supramolecular Hybrid Structures and Gels from Host–Guest Interactions between α-Cyclodextrin and PEGylated Organosilica Nanoparticles

et al. 2018

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Polypseudorotaxanes are polymer chains threaded by molecular rings that are free to unthread; these "pearl-necklace" can self-assemble further, leading to higher-order supramolecular structures with interesting functionalities. In this work, the complexation between α-cyclodextrin (α-CD), a cyclic oligosaccharide of glucopyranose units, and poly(ethylene glycol) (PEG) grafted to silica nanoparticles was studied. The threading of α-CD onto the polymeric chains leads to their aggregation into bundles, followed by either the precipitation of the inclusion complex or the formation of a gel phase, in which silica nanoparticles are incorporated. The kinetics of threading, followed by turbidimetry, revealed a dependence of the rate of complexation on the following parameters: the concentration of α-CD, temperature, PEG length (750, 4000, and 5000 g mol), whether the polymer is grafted or free in solution, and the density of grafting. Complexation is slower, and temperature has a higher impact on PEG grafted on silica nanoparticles compared to PEG free in solution. Thermodynamic parameters extracted from the transition-state theory showed that inclusion complex formation is favored with grafted PEG compared to free PEG and establishes a ratio of complexation of five to six ethylene oxide units per cyclodextrin. The complexation yields, determined by gravimetry, revealed that much higher yields are obtained with longer chains and higher grafting density. Thermogravimetric analysis and Fourier transform infrared spectroscopy on the inclusion complex corroborate the number of macrocycles threaded on the chains. A sol-gel transition was observed with the longer PEG chain (5k) at specific mixing ratios; oscillatory shear rheology measurements confirmed a highly solid-like behavior, with an elastic modulus G' of up to 25 kPa, higher than that in the absence of silica. These results thus provide the key parameters dictating inclusion complex formation between cyclodextrin and PEG covalently attached to colloidal silica and demonstrate a facile route toward soft nanoparticle gels based on host-guest interactions.

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Hydrogel Dressings

Cited by 7 publications

References 119 publications

Advances in Three Dimensional Bioprinting for Wound Healing: A Comprehensive Review

Advances in Three Dimensional Bioprinting for Wound Healing: A Comprehensive Review

Nanomaterials for Wound Dressings: An Up-to-Date Overview

Supramolecular Hybrid Structures and Gels from Host–Guest Interactions between α-Cyclodextrin and PEGylated Organosilica Nanoparticles

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