Hydrogel-based vascular grafts: State of art

Oztemur, Janset; Ozdemir, Suzan; Sezgin, Hande; Yalcin-Enis, Ipek

doi:10.1016/b978-0-323-91753-7.00011-9

Cited by 2 publications

(1 citation statement)

References 102 publications

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“…On the other hand, vascular grafts are successful to the extent that they can mimic native vessels and approximate the artificial tissue to native tissues in all their properties. The designed vascular grafts should match the native vascular structure, which is a very complex structure, in terms of physical, histological, topographic and biological properties as well as mechanical properties [7]. The vascular structure, which is subjected to many loads such as blood pressure and stress cycling, must have burst strength to prevent aneurysmal expansion [8].…”

Section: Introductionmentioning

confidence: 99%

A Preliminary Study Examining the Burst Strength of Vascular Tubular Scaffolds

OZTEMUR¹,

ÖZDEMIR²,

SEZGIN³

et al. 2023

Fibres and Textiles

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In this study, neat PCL, neat PLA and PLA/PCL (50/50) based tubular surfaces are produced by electrospinning to simulate the native blood vessel structure and to investigate the effects of both graft material and fiber orientation on burst strength. The burst pressure values of these vascular graft structures that designed with both randomly oriented fibers and oriented fibers, measured by a custom- burst pressure tester, and the results are compared. The results show that fiber orientation have a great influence on burst pressure, regardless of the type of biomaterial. It is determined that grafts with oriented fibers have at least twice the burst strength than those with random fibers. The findings indicate that changing the graft material has also an effect on burst strength. When the results are analyzed by polymer type, although the PLA100_O sample has the highest burst strength among all oriented fiber sample groups, it is better to determine the vascular graft candidate by taking into account radial elasticity.

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Section: Introductionmentioning

confidence: 99%