Hydrogel-Based Drug Delivery Systems for Poorly Water-Soluble Drugs

McKenzie, Matthew; Betts, David R.; Suh, Amy; Bui, Kathryn; Kim, London Doyoung; Cho, Hyunah

doi:10.3390/molecules201119705

Cited by 164 publications

(127 citation statements)

References 49 publications

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“…Among a variety of DDS, hydrogels—a class of three‐dimensional cross‐linked networks of polymers—can present a superior therapeutic solution against AD . The hydrophilic nature of hydrogels ensures that they can retain large amounts of water at the lesion site, while their mechanical structure prevents the disruption of the polymer . Their woven matrices allow the supply of pharmaceutical agents to the AD lesion while preventing pathogens from getting in .…”

Section: Introductionmentioning

confidence: 99%

“…10 The hydrophilic nature of hydrogels ensures that they can retain large amounts of water at the lesion site, while their mechanical structure prevents the disruption of the polymer. 11 Their woven matrices allow the supply of pharmaceutical agents to the AD lesion while preventing pathogens from getting in. 10 Additionally, hydrogels do not easily bind to hydrophilic surfaces of the lesion, thus the potential to cause a detachment-induced irritation might be reduced when compared to the other forms of topical DDS.…”

Section: Introductionmentioning

confidence: 99%

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Topical film prepared with Rhus verniciflua extract‐loaded pullulan hydrogel for atopic dermatitis treatment

Jeong

Back

et al. 2019

J Biomed Mater Res

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Atopic dermatitis (AD) is characterized by relapsing pruritus and skin dryness. Due to the pathogenic multiplicity and the adverse effects associated with the current therapeutics, development of transdermal drug delivery system is becoming an area of interest. Here, a novel topical film prepared with Rhus verniciflua extract (RVE)‐loaded pullulan hydrogel (RVE@PH) was synthesized and tested its therapeutic efficacy on the AD rats modeled by neonatal capsaicin injection method. The RVE@PH was characterized by a Fourier‐transform infrared spectroscopy and an in vitro release assay. Rat pups were randomly divided into two groups: vehicle‐treated (VEH; n = 5) and capsaicin‐treated (n = 15). The latter were given capsaicin subcutaneously at 24 h after birth for AD induction and further divided into three groups (n = 5 per each): not treated (CAP), pullulan hydrogel‐applied (PH), and RVE@PH‐applied (RVE‐PH). The pullulan hydrogel and RVE@PH were topically applied on shoulder lesions for 14 days (from 42 to 56 days after birth). Their phenotypes were compared based on the dermatitis score, epidermal thickness, mast cell infiltration, and serum myeloperoxidase (MPO) activities. The PH group showed significant attenuation in all the aforementioned values compared to the CAP group, suggesting that pullulan hydrogel itself has therapeutic activity against AD. Notably, the attenuations were more potent in the RVE‐PH group than the PH group, indicating that the therapeutic efficacy against AD is augmented by the presence of RVE, a loaded pharmaceutic. Collectively, these results indicate that RVE@PH inhibits AD through exerting the dual roles, that is, the pullulan hydrogel‐mediated physical and RVE‐mediated pharmaceutical actions. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B: 2325–2334, 2019.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Topical film prepared with Rhus verniciflua extract‐loaded pullulan hydrogel for atopic dermatitis treatment

Jeong

Back

et al. 2019

J Biomed Mater Res

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“…Above the critical micelle temperature, the aggregation of PF occurs, which causes micellization due to the dehydration of PEO and PPO blocks. The micellization yields a three‐dimensional structure, which holds the water molecules in its network . Figure (b) shows the complex viscosity of PF/XG/SLN hydrogel as a function of temperature.…”

Section: Resultsmentioning

confidence: 99%

Solid lipid nanoparticles loaded thermoresponsive pluronic–xanthan gum hydrogel as a transdermal delivery system

Lee

Shin

Park

2017

J of Applied Polymer Sci

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The aim of this study was to develop and investigate thermoresponsive hydrogel incorporating curcumin (Cur) for application as a transdermal delivery system. Cur was encapsulated within solid lipid nanoparticles via ultrasonic homogenization, and these were introduced into a thermoresponsive hydrogel composed of pluronic F68 (PF68) and F127 (PF127). The hydrogel composed of PF68 and PF127 in 10:90 ratio transformed from sol to gel at 29.3 °C close to skin temperature. The skin adhesiveness and adhesive strength of the hydrogel with 0.2% (w/w) of XG was 1.64 and 1.24 times higher than those of the hydrogel without XG, respectively. The physiochemical characteristics of prepared formulations were investigated via observation of particle size, polydispersity index, transmission electron microscopy, and scanning electron microscopy. Moreover, Fourier transform infrared spectroscopy analysis was performed at physiological temperature, which revealed lower hydrogen bonding intensity at gel phase than at sol phase. The cumulative amount of Cur that penetrated significantly increased compared with the Cur ethanol solution. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 46004.

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“…In recent years, hydrogel-based drug delivery system has been used to encapsulate hydrophobic molecules for sustained release of therapeutic agents. 27 Diffusioncontrolled release is considered to be the primary mechanism of release of therapeutic molecules from the hydrogel matrix. 28,29 Thermosensitive chitosan-based hydrogel has been reported to show a sustained release profile of hydrophobic molecules from few days to weeks.…”

Section: Discussionmentioning

confidence: 99%

Sustained release of levofloxacin from thermosensitive chitosan‐based hydrogel for the treatment of postoperative endophthalmitis

Cheng

Chang

et al. 2019

J Biomed Mater Res

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In the field of ophthalmology, postoperative endophthalmitis (POE) is a serious surgical complication, which may lead to poor visual outcome even after the infection has been controlled. In the study, we develop a sustained drug releasing system loaded with levofloxacin which is expected to be effective against common pathogens responsible for POE for at least 7 days after single application at the end of surgery. The results of study showed that the sol–gel transition temperature of the levofloxacin‐loaded chitosan‐gelatin‐based solution was ~34°C. The gelation time of the developed formulation was ~81 s at 34°C. The results showed that the osmolality of developed hydrogel was 304 mOsm/L. The in vitro drug release studies revealed that levofloxacin release from the developed hydrogel displayed a sustained‐release profile. The long‐term antibacterial property of the developed hydrogel has been demonstrated. The biocompatibility of the developed hydrogel was evaluated in vitro. These results suggest that the levofloxacin‐containing hydrogel could be applied to ocular surface at the end of ophthalmic surgery, without the risks of intracameral injection of antibiotics. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 108B:8–13, 2020.

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Hydrogel-Based Drug Delivery Systems for Poorly Water-Soluble Drugs

Cited by 164 publications

References 49 publications

Topical film prepared with Rhus verniciflua extract‐loaded pullulan hydrogel for atopic dermatitis treatment

Topical film prepared with Rhus verniciflua extract‐loaded pullulan hydrogel for atopic dermatitis treatment

Solid lipid nanoparticles loaded thermoresponsive pluronic–xanthan gum hydrogel as a transdermal delivery system

Sustained release of levofloxacin from thermosensitive chitosan‐based hydrogel for the treatment of postoperative endophthalmitis

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