Solid lipid nanoparticles loaded thermoresponsive pluronic–xanthan gum hydrogel as a transdermal delivery system

Lee, Hyo-Geun; Shin, Gye Hwa; Park, Hyun Jin

doi:10.1002/app.46004

Cited by 47 publications

(18 citation statements)

References 49 publications

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“…Nanocarriers were developed using the amphiphilic polymer P68 as it has been successfully used to develop micellar nanocarriers of numerous compounds [39][40][41] including curcumin for other indications [42][43][44][45]. Mitochondrial targeting of nanocarriers using dequilinium has been established [25,29,46] therefore, the addition of dequilinium to the nanoformulation was used to assess whether mitochondrial targeting would result in increased potency.…”

Section: Discussionmentioning

confidence: 99%

Deferoxamine and Curcumin Loaded Nanocarriers Protect Against Rotenone-Induced Neurotoxicity

Mursaleen

Somavarapu

Zariwala

2020

JPD

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Introduction: Reduced glutathione and excess free iron within dopaminergic, substantia nigra neurons in Parkinson's disease (PD) can drive accumulation of toxic hydroxyl radicals resulting in sustained oxidative stress and cellular damage. Factors such as brain penetrance and bioavailability have limited the advancement of potential antioxidant and iron chelator therapies for PD. Objective: This study aimed to develop novel nanocarrier delivery systems for the antioxidant curcumin and/or iron chelator deferoxamine (DFO) to protect against rotenoneinduced changes in cell viability and oxidative stress in SH-SY5Y cells. Method: Nanocarriers of curcumin and/or DFO were prepared using Pluronic F68 (P68) with or without dequilinium (DQA) by modified thin-film hydration. Cell viability was assessed using an MTT assay and oxidative stress was measured using Thiobarbituric acid reactive substances (TBARS) and cellular antioxidant activity (CAA) assays. Results: All formulations demonstrated high encapsulation efficiency (65-96%) and nanocarrier size was <200nm. 3h-pretreatment with P68 or P68+DQA nanocarriers containing various concentrations of curcumin and/or DFO significantly protected against rotenone-reduced cell viability. The addition of DFO to curcumin-loaded P68+DQA nanocarriers resulted in increased protection by at least 10%. All nanoformulations significantly protected against rotenone-induced lipid peroxidation (p < 0.0001). The addition of DQA, which targets mitochondria, resulted in up to 65% increase in cellular antioxidant activity. In nearly all preparations, the combination of 10uM curcumin and 100uM DFO had the most antioxidant activity. Conclusion: This study demonstrates for the first time the formulation and delivery using P68 and P68+DQA curcumin and/or DFO nanocarriers to protect against oxidative stress induced by a rotenone PD model. This strategy to combine antioxidants with iron chelators may provide a novel approach to fully utilise their therapeutic benefit for PD.

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Section: Discussionmentioning

confidence: 99%

Deferoxamine and Curcumin Loaded Nanocarriers Protect Against Rotenone-Induced Neurotoxicity

Mursaleen

Somavarapu

Zariwala

2020

JPD

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“…In addition to LCST and UCST hydrogels, the thermoresponsive sol‐gel transition from a liquid to gel phase may also be relevant in the design of transformer hydrogels . Several natural polymers such as amylose, agarose, xanthan gum, and starch or synthetic hydrogels like copolymers of pNIPAM with pEG (polyethylene glycol), poloxamers like pluronic, and pEG/pGLA block copolymers show this behavior …”

Section: Principlesmentioning

confidence: 99%

Transformer Hydrogels: A Review

Erol

Pantula

Liu

et al. 2019

Adv Materials Technologies

221

211

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Hydrogels, which are hydrophilic soft porous networks, are an important class of materials of broad relevance to bioanalytical chemistry, soft‐robotics, drug delivery, and regenerative medicine. Transformer hydrogels are micro‐ and mesostructured hydrogels that display a dramatic transformation of shape, form, or dimension with associated changes in function, due to engineered local variations such as in swelling or stiffness, in response to external controls or environmental stimuli. This review describes principles that can be utilized to fabricate transformer hydrogels such as by layering, patterning, or generating anisotropy, and gradients. Transformer hydrogels are classified based on their responsivity to different stimuli such as temperature, electromagnetic fields, chemicals, and biomolecules. A survey of the current research progress suggests applications of transformer hydrogels in biomimetics, soft robotics, microfluidics, tissue engineering, drug delivery, surgery, and biomedical engineering.

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“…They lack adhesiveness, particularly with regard to biological tissues such as skin, nasal or lung mucosa, for instance. Therefore, Lee et al added to an LNP-poloxamer hydrogel formulation a small amount of xanthan, a biocompatible polysaccharide known for its bio-adhesion properties, as well as its ability to considerably delay drug delivery [49]. In this recent study, curcumin-loaded lipid nanoparticles were added to an aqueous solution of 23% ( w / w ) mixture of poloxamer (407 and 188), 0.05% to 0.20% ( w / w ) xanthan, and double-distilled water, to create a hydrogel for transdermal drug delivery.…”

Section: Hydrogels As Lipid Nanoparticle Scaffoldsmentioning

confidence: 99%

Lipid Nanoparticles and Their Hydrogel Composites for Drug Delivery: A Review

2018

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Several drug delivery systems already exist for the encapsulation and subsequent release of lipophilic drugs that are well described in the scientific literature. Among these, lipid nanoparticles (LNP) have specifically come up for dermal, transdermal, mucosal, intramuscular and ocular drug administration routes in the last twenty years. However, for some of them (especially dermal, transdermal, mucosal), the LNP aqueous dispersions display unsuitable rheological properties. They therefore need to be processed as semi-solid formulations such as LNP-hydrogel composites to turn into versatile drug delivery systems able to provide precise spatial and temporal control of active ingredient release. In the present review, recent developments in the formulation of lipid nanoparticle-hydrogel composites are highlighted, including examples of successful encapsulation and release of lipophilic drugs through the skin, the eyes and by intramuscular injections. In relation to lipid nanoparticles, a specific emphasis has been put on the LNP key properties and how they influence their inclusion in the hydrogel. Polymer matrices include synthetic polymers such as poly(acrylic acid)-based materials, environment responsive (especially thermo-sensitive) polymers, and innovative polysaccharide-based hydrogels. The composite materials constitute smart, tunable drug delivery systems with a wide range of features, suitable for dermal, transdermal, and intramuscular controlled drug release.

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Solid lipid nanoparticles loaded thermoresponsive pluronic–xanthan gum hydrogel as a transdermal delivery system

Cited by 47 publications

References 49 publications

Deferoxamine and Curcumin Loaded Nanocarriers Protect Against Rotenone-Induced Neurotoxicity

Deferoxamine and Curcumin Loaded Nanocarriers Protect Against Rotenone-Induced Neurotoxicity

Transformer Hydrogels: A Review

Lipid Nanoparticles and Their Hydrogel Composites for Drug Delivery: A Review

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