Hydroethanolic leaf extract of <i>Acacia auriculiformis</i> exhibited antidiabetic and antioxidant activities

Sharma, Divya; Verma, Surender; Kumar, Sunil; Singh, Jitender; Kumar, Ravi; Jangra, Ashok; Kumar, Dinesh

doi:10.1080/2314808x.2022.2100674

Cited by 3 publications

(6 citation statements)

References 35 publications

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“…The hypoglycaemic property of the legumes was owing to the indirect or direct stimulation of the β–cells of islets of Langerhans to release more insulin [ 138 ]. The other study suggests that a hydroethanolic leaf extract of A. auriculiformis possesses good antioxidant and enzyme inhibitory potential, which, in turn, might be responsible for its antidiabetic effects [ 29 ]. Similarly, A. catechu extracts showed an antidiabetic activity towards porcine pancreatic α -amylase, [ 139 ] with an IC 50 of 49.9 μg/mL.…”

Section: Pharmacological Activitiesmentioning

confidence: 99%

Bioactive Compounds, Pharmacological Actions, and Pharmacokinetics of Genus Acacia

et al. 2022

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Plants are a promising source of bioactive compounds that can be used to tackle many emerging diseases both infectious and non-infectious. Among different plants, Acacia is a very large genus and exhibits a diverse array of bioactive agents with remarkable pharmacological properties against different diseases. Acacia, a herb found all over the world, contains approximately more than 1200 species of the Fabaceae family. In the present review, we have collected detailed information on biochemical as well as pharmacological properties. The data were retrieved using different databases, such as Elsevier, PubMed, Science Direct, Google Scholar, and Scopus, and an extensive literature survey was carried out. Studies have shown that Acacia possesses several secondary metabolites, including amines, cyanogenic glycosides, flavonoids, alkaloids, seed oils, cyclitols, fluoroacetate, gums, non-protein amino acids, diterpenes, fatty acids, terpenes, hydrolyzable tannins, and condensed tannins. These compounds exhibit a wide range of pharmaceutical applications such as anti-inflammatory, antioxidant, antidiarrheal, antidiabetic, anticancer, antiviral, liver protective effects, and so on. Thus, the literature shows the tremendous phytochemical impact of the genus Acacia in medicine. Overall, we recommend that more research should be conducted on the medicinal value and isolation and purification of the effective therapeutic agents from Acacia species for the treatment of various ailments.

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Section: Pharmacological Activitiesmentioning

confidence: 99%

Bioactive Compounds, Pharmacological Actions, and Pharmacokinetics of Genus Acacia

et al. 2022

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“…Diabetes Mellitus is categorized into two classes: Type 1 and Type 2. In Type 1 Diabetes Melitis, insulin production is insufficient due to damage to pancreatic β cells, whereas Type 2 Diabetes Melitis is manifested by impaired insulin secretion in pancreatic β cells or by insulin resistance causing hyperglycemia [1], [6].…”

Section: Introductionmentioning

confidence: 99%

“…Plants are widely known as natural antioxidant agents [11]. Thus, free radical scavenging natural product therapy may prove a useful therapeutic tactic in diabetes control [6]. There are several therapeutic approaches in the management of DM to reduce postprandial hyperglycemia by inhibiting carbohydrate hydrolyzing enzymes, such as α-amylase and α-glucosidase [12].…”

Section: Introductionmentioning

confidence: 99%

“…(family: Fabaceae) commonly known as the Australian babool or earpod wattle. It is enriched with carbohydrates such as glucuronic acid, methyl glucuronic acid, galactose, L-rhamnose and arabinose, and the seeds contain saponins, especially, proacaciaside-I and proacaciaside-II and Acaciaside-A and Acaciaside B and flavonoids, namely, (-)-teracacidin and (-)-isoteracidin [6]. This plant has been reported to have several biological activities, namely antimutagenic and chemopreventive, antidiabetic, antimalarial and antiulcer activity [15].…”

Section: Introductionmentioning

confidence: 99%

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Study Literature: Acacia Plants Lower Blood Sugar

Tedi

2023

CHIPROF

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Background: Diabetic is a chronic disease that occurs because the pancreas cannot produce enough insulin or the body cannot use insulin actively which results in high blood sugar levels. One way to prevent diabetes is to provide non-pharmacological therapies such as the use of herbal plants. One of the herbal plants that can be used in the prevention of diabetes is the acacia plant (Acacia Nicoleta). Method: The method used a literature study with a search from various sources, such as academic journals, and online articles. A literature search was carried out using keywords related to Acacia Nicoleta and diabetes. Result: in a literature review acacia can lower blood sugar levels because acacia plants contain carbohydrates, proteins, and minerals as well as secondary metabolites in the form of alkaloids, tannins, and saponins. Conclusion: acacia plant is proven to reduce blood sugar so it is expected to use the acacia plant as a non-pharmacological therapy in diabetics.

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“…3 The plant has reportedly demonstrated a range of pharmacological properties, including antioxidant & anti-inflammatory 4 , antibacterial & antifungal, 5 antimalarial, 6 antifilarial, 7 cestocidal, 8 antimutagenic & chemopreventive, 9 spermicidal, 10 hepatoprotective, 11 wound-healing, 12 and antidiabetic action. 13 Auriculoside, a flavan glycoside isolated from A. auriculiformis, was found to have central nervous system depressive action. 14 A useful tool for establishing plant quality control parameters is pharmacognostic standardization.…”

Section: Introductionmentioning

confidence: 99%

Formulation and Evaluation of Antimicrobial Ointment from Acacia auriculiformis Leaves Extract

Telrandhe,

Galat,

Chavan

et al. 2022

IJDDT

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The current experiment aims to create and test an ointment with an ethanolic extract from Acacia auriculiformis for antimicrobial action. The soxhalation procedure was used to create the ethanolic extract. After producing the ointment base, five batches of ointments were created by incorporating the extract into the base. Physical and chemical properties of each formulation, including color, flavor, pH, spreadability, consistency, solubility, and washability, were assessed. The formulation’s stability at different temperature conditions was also assessed, and the results show that neither its irritancy nor its spreadability has changed. F5 was discovered to be the ideal formulation among the ointment batches. It has a larger zone of inhibition over both gram-positive and gram-negative bacteria.

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Hydroethanolic leaf extract of Acacia auriculiformis exhibited antidiabetic and antioxidant activities

Cited by 3 publications

References 35 publications

Bioactive Compounds, Pharmacological Actions, and Pharmacokinetics of Genus Acacia

Bioactive Compounds, Pharmacological Actions, and Pharmacokinetics of Genus Acacia

Study Literature: Acacia Plants Lower Blood Sugar

Formulation and Evaluation of Antimicrobial Ointment from Acacia auriculiformis Leaves Extract

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