Hydrodynamics and mass transfer studies in a novel external-loop airlift reactor

Guo, Yali; Rathor, M.N.; Ti, Hwei Chen

doi:10.1016/s1385-8947(97)00043-0

Cited by 57 publications

(46 citation statements)

References 21 publications

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“…Thus, the resulting large driving force leads to a large increase in liquid circulation velocity at low superficial gas velocities, whereas at larger gas velocities, the liquid circulation velocity tends to level off. Similar behavior has been reported [15,16]. In stage 1, an almost constant circulation velocity was obtained with increasing superficial gas velocity.…”

Section: Liquid Circulation Velocitysupporting

confidence: 88%

Hydrodynamics of a Multi‐Stage Internal Loop Airlift Reactor

Zhang

et al. 2008

Chem Eng & Technol

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The local hydrodynamic properties in a multi-stage internal loop airlift reactor were investigated in this study. The gas-liquid two-phase flow hydrodynamic properties, including gas holdup, bubble velocity, bubble diameter, and liquid circulation velocity at various stages were measured by dual electrical resistivity probes and conductivity cells. Detailed studies on the gas holdup, bubble velocity, bubble diameter, and liquid circulation velocity were conducted with respect to various values of superficial gas. The Zuber and Findlay drift flux model was used to represent the variation of slip velocity with total gas-liquid velocity at various stages and the model fits the data well.

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Section: Liquid Circulation Velocitysupporting

confidence: 88%

Hydrodynamics of a Multi‐Stage Internal Loop Airlift Reactor

Zhang

et al. 2008

Chem Eng & Technol

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“…In an effort to reduce shear stress in an external-loop airlift reactor, Guo et al (1997) placed the sparger high in the riser section (Figure 1c). Increasing the aspect ratio of concentric tube airlifts can lead to a greater ability to suspend solids (Ganzeveld et al 1995), which is critical in a fluidized bed configuration, using immobilized biocatalysts on a solid support.…”

Section: Reduced Shear Stress and Mixingmentioning

confidence: 99%

Bioprocess Intensification for Production of Novel Marine Bacterial Antibiotics Through Bioreactor Operation and Design

1999

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: There is a lack of research into bioreactor engineering and fermentation protocol design in the field of marine bacterial antibiotic production. Most production strategies are carried out at the shake-flask level and lack a mechanistic understanding of the antibiotic production process, offering poor prospects for successful scale-up. This review shows that data need to be collated on media and physical optima differences between the trophophase and idiophase, along with investigations into the control mechanisms for biosynthesis, to allow implementation of novel fermentation protocols. Immobilization may play a part in bioprocess intensification of marine bacterial antibiotic production, through again this area is understudied. Similarly, mass transfer and shear stress data of fermentations are needed to provide the bioreactor design requirements to intensify antibiotic biosynthesis, with process scale-up in mind. The application of bioprocess intensification methods to the production of antibiotics (and other metabolites) from marine microbes will become an important strategy for improving supply of natural products, in order to assess their suitability as chemotherapeutic drugs.

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“…Some systems show an enhanced k L a [3][4][5] and some systems measure a decreased k L a [6,7] relative to systems without particles. It is clear, however, that the effect of the particles on the system is a function of particle properties, vessel and impellor dimensions and arrangement and operating conditions [8,9].…”

Section: Introductionmentioning

confidence: 96%