Hydrodynamic Behavior of High Molar Mass Linear Polyglycidol in Dilute Aqueous Solution

Abstract

Six high molar mass polyglycidol samples were obtained by fractionation of polyglycidol synthesized by means of cationic polymerization of ethoxyethyl glycidyl ether followed by cleavage of the protective groups. The fractions covering the molar mass range from 0.1 to 2.4 x 10(6) were studied by dynamic and static light scattering. The weight-average molar masses (Mw), second virial coefficients (A2), radii of gyration (Rg), diffusion coefficients (D0), hydrodynamic radii (Rh), and dynamic virial coefficients (kDphi) were determined for the single coil in dilute aqueous solution at 25 degrees C, and scaling equations were established. It was found that polyglycidol in water does not exhibit the expected asymptotic good solvent behavior. The scaling exponents for A2, D0, and Rh are even closer to those for polymer coils in marginal solvents than to the expected ones in the excluded-volume region. The values of the interpenetration parameter, psi, and kDphi are far from reaching limiting values even for the fractions of the highest molar masses. The scaling exponent for Rg as well as the Rg/Rh ratio, which was found to increase with increasing molar mass, imply elongated coil conformation in the high molar mass region.

Nanostructures by self-assembly of polyglycidol-derivatized lipids

“…This nding can be rationalized recalling that at lower temperatures polyglycidol exhibits behavior that is closer to that for polymer coils in marginal solvents. 46 At such conditions DDP and polyglycidol chains are not fully segregated and we can speculate that the polyglycidol chain partially covers the lipid mimetic anchor thus effectively decreasing the portion of DDP that is exposed to water; the longer the chain, the smaller the portion (Scheme 2). At elevated temperatures the solubility of polyglycidol increases; it goes preferentially in the aqueous phase thus exposing the whole hydrophobic anchor to water (Scheme 2), which is expected to facilitate the self-assembly and to decrease the CMCs.…”

Modulation of Stem Cell Adhesion and Morphology via Facile Control over Surface Presentation of Cell Adhesion Molecules

“…PEO chains (based on a hydrodynamic radius of each PEO chain (11000 g/mol) of ~ 2.2 nm (calculated according to the method described in [22])). The functionalised β-CD-RGD is estimated to be of a similar size to the PEO (β-CD alone is 1.66 nm), meaning that at maximum packing on the outer rim of one cylinder composed of 75% PS-PEO-Ada, we may obtain ~27 conjugated CD-RGD molecules.…”

Synthesis and degradation of biomedical materials based on linear and star shaped polyglycidols

“…It has been shown, that if the propagating chain end is not a “free” alkoxide, high molecular weight polyglycidol can be obtained. By the use of partially hydrolyzed diethylzinc as catalyst, the basicity of the propagating alkoxide is suppressed by coordination to the zinc 41–43. Proton abstraction is efficiently avoided.…”