Nanostructures by self-assembly of polyglycidol-derivatized lipids

Bakardzhiev, Pavel; Rangelov, Stanislav; Trzebicka, Barbara; Momekova, Denitsa; Lalev, G.; Garamus, Vasil M.

doi:10.1039/c4ra03102d

Cited by 16 publications

(14 citation statements)

References 53 publications

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“…The resulting values are listed in the last column of Table . With values ranging in the 0.016–0.091 g mL −1 interval, the polyplex particles are denser than a polymer coil in a good solvent but less dense (roughly an order of magnitude) than the familiar block copolymer micelles in aqueous and nonaqueous solutions. In other words, the polyplex particles contained considerably more water (solvent) than the copolymer micelles.…”

Section: Resultsmentioning

confidence: 99%

Determination of Intimate Composition of Theranostic Polyplexes Based on (Co)Polymers of Poly(vinyl benzyl trimethylammonium chloride)

Haladjova

Mountrichas

Pispas

et al. 2017

Macro Chemistry & Physics

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Nonviral DNA CarriersNovel hybrid nanoparticulate systems that exhibit potential to combine therapeutic, diagnostic, and sensing modalities in a single nanoparticle are investigated. They are composed of a homopolymer of poly(vinyl benzyl trimethylammonium chloride) (or its copolymer with poly[oligo(ethylene glycol) methacrylate]), DNA, and gold nanoparticles (AuNPs). Using the approach of classic dynamic and static light scattering, parameters such as molar mass, particle size, geometry and density, and intimate composition are determined, trying to establish what the theranostic polyplexes really carry. According to the analysis, the polyplex particles are composed of up to 154 DNA molecules and 1612 (co)polymer molecules at amino-to-phosphate groups ratio (N/P) of 0.5 and 1 DNA and up to 252 (co)polymer molecules at higher N/P ratios. The particle morphology is consistent with "hairy surface on a compact sphere" with density that is lower than the density of the familiar copolymer micelles. The introduction of AuNPs does not influence the density and structure of the carriers, which could be related to the low number fraction of polyplex particles carrying AuNPs. Additional data from transmission electron microscopy, electrophoretic light scattering, and analytical ultracentrifugation validate the morphology, structure, and molar mass of the theranostic nanoassemblies and confirm the conclusions derived from light scattering.

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Section: Resultsmentioning

confidence: 99%

Determination of Intimate Composition of Theranostic Polyplexes Based on (Co)Polymers of Poly(vinyl benzyl trimethylammonium chloride)

Haladjova

Mountrichas

Pispas

et al. 2017

Macro Chemistry & Physics

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“…Garamus and co-workers synthesized polyglycidol-derivatized lipids using a 1,3-didodecyl/tetradecyloxy-propane-2-ol (DDP) initiator. They studied the self-assembly behavior and determined CMC values …”

Section: Poly(alkylene Oxide) Structures: Innovative Polyether Struct...mentioning

confidence: 99%

“…They studied the self-assembly behavior and determined CMC values. 255 If single amine functionalities at the α-terminus of PEG are desired, a synthetic detour is indispensable. The use of initiators bearing unprotected amines is not possible, given the nucleophilicity of amines and would result in a mixture of polymers initiated by alcohol and amine.…”

Section: Multifunctional Pegsmentioning

confidence: 99%

Polymerization of Ethylene Oxide, Propylene Oxide, and Other Alkylene Oxides: Synthesis, Novel Polymer Architectures, and Bioconjugation

et al. 2015

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The review summarizes current trends and developments in the polymerization of alkylene oxides in the last two decades since 1995, with a particular focus on the most important epoxide monomers ethylene oxide (EO), propylene oxide (PO), and butylene oxide (BO). Classical synthetic pathways, i.e., anionic polymerization, coordination polymerization, and cationic polymerization of epoxides (oxiranes), are briefly reviewed. The main focus of the review lies on more recent and in some cases metal-free methods for epoxide polymerization, i.e., the activated monomer strategy, the use of organocatalysts, such as N-heterocyclic carbenes (NHCs) and N-heterocyclic olefins (NHOs) as well as phosphazene bases. In addition, the commercially relevant double-metal cyanide (DMC) catalyst systems are discussed. Besides the synthetic progress, new types of multifunctional linear PEG (mf-PEG) and PPO structures accessible by copolymerization of EO or PO with functional epoxide comonomers are presented as well as complex branched, hyperbranched, and dendrimer like polyethers. Amphiphilic block copolymers based on PEO and PPO (Poloxamers and Pluronics) and advances in the area of PEGylation as the most important bioconjugation strategy are also summarized. With the ever growing toolbox for epoxide polymerization, a "polyether universe" may be envisaged that in its structural diversity parallels the immense variety of structural options available for polymers based on vinyl monomers with a purely carbon-based backbone.

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“…The samples were thermally equilibrated for 60 min before measurement and an average of 5 measurement runs were considered for getting the size of micelle. 24,25…”

Section: Dynamic Light Scattering (Dls) Measurementsmentioning

confidence: 99%