Hydrodynamic Assists Magnetophoreses Rare Cancer cells Separation in Microchannel Simulation and Experimental Verifications

Saeed, Omer; Duru, Lucienne; Deng, Yulin

doi:10.1088/1757-899x/350/1/012013

Cited by 1 publication

(1 citation statement)

References 21 publications

(19 reference statements)

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“…A low width/height ratio (e.g., 4:1) minimizes fluid volume but results in a non-uniform shear rate across the channel width. Conversely, a high width/height ratio (e.g., 10:1) ensures a more uniform shear rate profile but requires a larger fluid volume [7]. The literature presents numerous designs of microfluidic devices.…”

Section: Introductionmentioning

confidence: 99%

Features of Vat-Photopolymerized Masters for Microfluidic Device Manufacturing

Gatto,

Mengucci,

Mattioli-Belmonte

et al. 2024

Bioengineering

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The growing interest in advancing microfluidic devices for manipulating fluids within micrometer-scale channels has prompted a shift in manufacturing practices, moving from single-component production to medium-size batches. This transition arises due to the impracticality of lab-scale manufacturing methods in accommodating the increased demand. This experimental study focuses on the design of master benchmarks 1–5, taking into consideration critical parameters such as rib width, height, and the relative width-to-height ratio. Notably, benchmarks 4 and 5 featured ribs that were strategically connected to the inlet, outlet, and reaction chamber of the master, enhancing their utility for subsequent replica production. Vat photopolymerization was employed for the fabrication of benchmarks 1–5, while replicas of benchmarks 4 and 5 were generated through polydimethylsiloxane casting. Dimensional investigations of the ribs and channels in both the master benchmarks and replicas were conducted using an optical technique validated through readability analysis based on the Michelson global contrast index. The primary goal was to evaluate the potential applicability of vat photopolymerization technology for efficiently producing microfluidic devices through a streamlined production process. Results indicate that the combination of vat photopolymerization followed by replication is well suited for achieving a minimum rib size of 25 µm in width and an aspect ratio of 1:12 for the master benchmark.

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Section: Introductionmentioning

confidence: 99%