This article reviews the recent developments in microfluidic technologies for in vitro cancer diagnosis. We summarize the working principles and experimental results of microfluidic platforms for cancer cell detection, and separation based on magnetic activated micro-sorting, and differences in cellular biophysics (e.g., cell size and dielectrophoresis (DEP)).
Abstract. The different type of blood entities like red blood cells (RBCs), white blood cell (WBCs) and platelets counts is a critical point in routine medical tests. Circulating tumor cells (CTCs) counting and analysing in the blood is indicative of the stage and origin of cancer in particular time. Here we are describing a proposed microfluidic device, used a magnetic means for CTCs separation from a blood or buffer sample. The device characterizations were simulated using COMSOL MULTIPHYSICS software as well as practically validated. Using a known spiked number of CTCs in the sample, the purity and recovery rate were calculated to be 93% and respectively.
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