Hydrocortisone 1% cream and sertaconazole 2% cream to treat facial seborrheic dermatitis: A double-blind, randomized clinical trial

Abstract

BackgroundSeborrheic dermatitis (SD) is a chronic dermatitis with periods of remission and relapse that requires long-term treatment.ObjectiveWe compared the efficacy and safety of treatment with sertaconazole with standard corticosteroid medications in adults with facial SD.MethodsIn this double-blind, randomized controlled trial, 60 patients with a diagnosis of SD were enrolled. Patients were instructed to apply either sertaconazole 2% cream (30 patients) or hydrocortisone 1% cream (30 patients) twice daily to the affected area of the face. The severity of facial SD was assessed at 0, 2, and 4 weeks of treatment. Secondary efficacy measures included patient assessment of seborrhea, adverse events, and improvement percentage (IP).ResultsSD lesions cleared significantly (p < .05) and similarly in both treatment groups (p > .05). Both treatments resulted in significant improvement of SD lesions and the rate of adverse events was similar in both groups. The IP was higher for treatment with hydrocortisone in Week 2 and similar in both groups at the end of the study.LimitationsLimitations include the small number of patients who were recruited for this study and the lack of evaluation of time to relapse.ConclusionTreatment with topical sertaconazole may be regarded as a substitute for topical corticosteroid medications due to the fewer adverse events and similar efficacy.

Evaluation of the effectiveness of triamcinolone solution diluted with normal saline for the treatment of seborrheic dermatitis

“…In addition, a clinical trial study by Balighi et al . [ 20 ] (2017) was performed for 60 patients with seborrheic dermatitis (30 patients receiving hydrocortisone and 30 patients receiving Sertaconazole). The results of the study showed that seborrheic dermatitis lesions were significantly reduced in both groups and were similar in recovery and frequency of complications in both groups.…”

Perkembangan Pengobatan Topikal Untuk Dermatitis Seboroik Wajah

“…Hal ini menjadi penting karena terbukti efek samping dari sertakonazol lebih ringan dan dapat dikaitkan dengan penggunaannya untuk pengobatan jangka panjang. 36 Kalsineurin inhibitor memiliki efektivitas yang sama dengan steroid. 35 Studi RCT yang dilakukan oleh Zhao, J et al mengevaluasi perbandingan keberhasilan pengobatan DS wajah dengan beberapa regimen pimekrolimus 1% selama empat minggu.…”