Hydroalcoholic Extract of Sechium edule Fruits Attenuates QT Prolongation in High Fat Diet-Induced Hyperlipidemic Mice

Abstract

The present study aimed to evaluate the effect of hydroalcoholic extract of Sechium edule (S.E.) fruits on lipid profile and electrocardiogram (ECG) parameters in high fat-diet (HFD) induced hyperlipidemic mice. In this study, grouping of animals was done as described below (n = 6), where group 1 is normal control, group 2 is HFD control, group 3 is HFD + atorvastatin (10 mg/kg), group 4 is HFD + S.E. extract (200 mg/kg), and group 5 is HFD + S.E. extract (400 mg/kg). The first 3 weeks animals were supplemented with HFD, and the last 3 weeks animals were supplemented with HFD along with atorvastatin (10 mg/kg) or S.E. extract (200 and 400 mg/kg). It was observed that mice of the HFD control group showed a significant rise in the total cholesterol, triglycerides, LDL-C, and VLDL-C levels and a notable decrease in HDL-C levels. In addition, a consequential increment in ECG parameters such as QT or QTc and RR interval and a noteworthy decline in the heart rate were observed in HFD control mice. Treatment with S.E. extract (200 and 400 mg/kg) showed a significant improvement in the lipid profile. Moreover, the extract also significantly normalized the prolonged QT or QTc and RR interval and the heart rate in HFD-challenged mice. Hence, we can conclude that S.E. extract encumbers the prolongation of QT or QTc and RR interval and increased the heart rate in HFD-challenged mice.

Study on the Pharmacological Mechanism of the Xihuang Pill and its Treatment of Breast Cancer Based on Nontargeted Metabonomics

“…With the gradual deepening of biotechnology research, some molecular compounds have been found to have impacts on some diseases. For example, F. S. Mohammed et al 12 showed that sechium edule extract results in the prolongation of QT or QTc and RR intervals and increases the heart rate in high-fat diet-challenged mice. S. Taifa et al 13 found that copper nanoparticles have an excellent effect on mastitis.…”

Xuanhuang Runtong Tablets Relieve Slow Transit Constipation in Mice by Regulating TLR5/IL‐17A Signaling Mediated by Gut Microbes

“…Treatment mainly focuses on invigorating Qi and nourishing Yin, moistening the intestines, and relieving constipation [6]. Various academic publications have reported on the Chinese herbal extracts'efects in treating intractable diseases [7][8][9], and the efects in treating constipation have also been confrmed [10].…”

Antihyperlipidemic mechanisms of a formula containing Curcuma xanthorrhiza, Sechium edule, and Syzigium polyanthum: In silico and in vitro studies

“…In the case of hyperlipidemia treatment, numerous medicinal plants have been used traditionally. Among them, Curcuma xanthorrhiza (Yasni et al, 1993), Sechium edule (Mohammed et al, 2022), and Syzigium polyanthum (Hartanti et al, 2019) have been reported to reduce serum lipid levels. In a previous study, extract combination of Sechium edule fruit, Syzigium polyanthum leaf, and Curcuma xanthorrhiza rhizome showed a good effect in reducing cholesterol total and triglyceride levels on male rats induced by high cholesterol diet (Agustini et al, 2006).…”