Hydroactive dressings and serum proteins: an in vitro study

Abstract

An in vitro approach was used to obtain information about the compatibility of hydroactive dressing materials with the serum proteins which are thought to be relevant to wound healing. Artificial wound fluid was incubated with different hydroactive dressings (Cutinova hydro, Varihesive E, Comfeel Ulcer Dressing and Allevyn), and concentrations of total protein, albumin, immunoglobulin and growth factors were measured after one day of incubation. Cutinova hydro and Allevyn absorbed considerable amounts of fluid. Fluid uptake was lower for the hydrocolloid dressings. An unexpected finding was that Cutinova hydro showed an approximately two-fold increase over control values in the concentration of all proteins tested, indicating a selective absorption of water by this dressing. For the other dressings tested, zero or very low absorption of proteins was found, indicating a basically satisfactory protein compatibility.

Dressings for chronic wounds

“…Hydroactive dressings are a spin‐off of hydrogels and combine the properties of hydrogels and foams, selectively absorbing excess water but leaving growth factors and other proteins behind . The appropriate applications for this type are thought to be similar to hydrocolloids.…”

“…If in gel form known as "amorphous gel," the hydrogel may simply be squeezed into the cavity and covered with a secondary dressing such as a film, foam, or hydrocolloid. Hydroactive dressings are a spin-off of hydrogels and combine the properties of hydrogels and foams, selectively absorbing excess water but leaving growth factors and other proteins behind (32). The appropriate applications for this type are thought to be similar to hydrocolloids.…”

Polyurethane dressing, tetracycline and salicylic acid use for treatment of digital dermatitis in cattle

“…Even though it is not known if pathogen numbers are reduced when a polyurethane dressing is used, it is thought that an accumulation of macrophages and proliferative cells contributes to the successful pathogen-fighting and healing process (1,9).…”

“…In humans, greater numbers of macrophages were found under the polyurethane wound dressing and the number of proliferative cells increased while the number of inflammatory cells decreased (9). The highly selective absorption capacity of this wound dressing leads to an increase in the concentration of metalloproteinases, proteolytic enzymes and various growth factors in the remaining wound fluid (1,9). This is important because during wound healing, it is necessary to absorb wound fluid during the exudative or cleaning phase to stimulate granulation during the proliferative phase and not impede reepithelialization during the restorative phase (40).…”

Composite Membrane Dressings System with Metallic Nanoparticles as an Antibacterial Factor in Wound Healing

“…The first line of bioactive dressings includes plasters immediately available for subacute and acute wounds, commonly used in clinical practice; the second line refers to unconventional (e.g., antimicrobial) dressings employed for complex chronic wounds. Among the examples of the first group are alginate [68][69][70], hydrogel [71][72][73][74], semi-permeable film [65], hydrocolloid [75][76][77], foam [78][79][80], and hydroactive [81,82] dressings [65]. In the second category, interactive hydrofibre [83], wet [65], silicone [84,85], honey [86][87][88], capillary wicking [89], hypertonic saline [90], silver [91][92][93][94], cadexomer iodine [95,96] dressings, and zinc paste bandages [97][98][99] are placed.…”