Hydro‐ethanolic extract of cashew tree (<i>Anacardium occidentale</i>) nut and its principal compound, anacardic acid, stimulate glucose uptake in C2C12 muscle cells

Tedong, Léonard; Madiraju, Padma; Martineau, Louis C.; Vallerand, Diane; Arnason, John T.; Désiré, Dzeufiet Djomeni Paul; Lavoie, Louis; Kamtchouing, P.; Haddad, Pierre S.

doi:10.1002/mnfr.201000045

Cited by 47 publications

(31 citation statements)

References 35 publications

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“…The ability of tree nuts to improve glycemic control may relate to activation of adenosine monophosphate-activated protein kinase in C2C12 myotubes as we demonstrated [1]. Our results are in line with a recent meta-analysis of randomized controlled dietary trials supporting the effect of tree nut on glycemic control in diabetes [15].…”

Section: Resultssupporting

confidence: 90%

“…In our previous studies, we found that hydro-ethanolic extract of cashew seed (CSE), stimulated glucose transport in C2C12 myotubes [1].…”

mentioning

confidence: 95%

“…Numerous cellular functions and enzymes, including ion channels, metabolic cycles, and signaling pathways are regulated by Mg 2+ . In our previous studies, we found that hydro-ethanolic extract of cashew seed (CSE) at a dose of 25ug/ml, 50ug/ml and 100ug/ml stimulated glucose transport in C2C12 myotubes in a concentration dependant-manner [1]. The stimulation of glucose uptake in skeletal muscle was increased through activation of Adenosine Monophosphate-Activated Protein Kinase (AMPk).…”

mentioning

confidence: 99%

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Magnesium Rich Extract of Cashew Tree (Anacardium Occidentale) Nut and its Principal Compound, Anacardic Acid, Stimulate Glucose Uptake in C2C12 Muscle Cells

Tedong¹,

Madiraju²,

Martineau³

et al. 2015

IJCAM

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Magnesium (Mg 2+ ) is the fourth most abundant cation in the whole body and the second most abundant cation within the cell. Numerous cellular functions and enzymes, including ion channels, metabolic cycles, and signaling pathways are regulated by Mg 2+ . In our previous studies, we found that hydro-ethanolic extract of cashew seed (CSE) at a dose of 25ug/ml, 50ug/ml and 100ug/ml stimulated glucose transport in C2C12 myotubes in a concentration dependant-manner [1]. The stimulation of glucose uptake in skeletal muscle was increased through activation of Adenosine Monophosphate-Activated Protein Kinase (AMPk). These scientific information's on magnesium and diabetes enable us to investigate magnesium content in cashew nut from Cameroon. From the data of the 9 plantations studied, the Cashews Nuts (CN) mean content in Mg was 271 mg/100g wet weight. We did not notice any significant difference between the farms in term of Mg content; remarkably, the Mg content of cashew nut 271mg/100g compared favorably with that of USDA nutrient database (292mg/100g) or Brazilian Mg CN content (277 mg/100 g). The result of this study showed that cashew nut from Garoua-Cameroon is nutritionally riches in term of mineral such as Mg and could be recommended for Magnesium deficient patients.

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Section: Resultssupporting

confidence: 90%

“…In our previous studies, we found that hydro-ethanolic extract of cashew seed (CSE), stimulated glucose transport in C2C12 myotubes [1].…”

mentioning

confidence: 95%

mentioning

confidence: 99%

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Magnesium Rich Extract of Cashew Tree (Anacardium Occidentale) Nut and its Principal Compound, Anacardic Acid, Stimulate Glucose Uptake in C2C12 Muscle Cells

Tedong¹,

Madiraju²,

Martineau³

et al. 2015

IJCAM

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“…80 Anacardic acid, which is present in cashew nuts, can inhibit several HATs, including PCAF, Tip60 and p300; 81 in addition, anacardic acid can also promote glucose uptake by myotubes through the activation of AMP-activated protein kinase (AMPK) and uncouple rat liver mitochondria, thus potentially contributing to enhanced glycolysis and glucose uptake. 81 Curcumin, the active compound of Curcuma longa (turmeric), a plant of the ginger family, has caught attention as a potential epidrug for diabetes, given its hypoglycemic, hypolipidemic, and epigenetic effects in various rodent models. 82 Curcumin has DNA hypomethylating activity and influences both histone acetylation and miRNA expression.…”

Section: Histone Acetyltransferase Inhibitorsmentioning

confidence: 99%

Clinical relevance of epigenetics in the onset and management of type 2 diabetes mellitus

et al. 2017

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Epigenetics is involved in the altered expression of gene networks that underlie insulin resistance and insufficiency. Major genes controlling b-cell differentiation and function, such as PAX4, PDX1, and GLP1 receptor, are epigenetically controlled. Epigenetics can cause insulin resistance through immunomediated pro-inflammatory actions related to several factors, such as NF-kB, osteopontin, and Toll-like receptors. Hereafter, we provide a critical and comprehensive summary on this topic with a particular emphasis on translational and clinical aspects. We discuss the effect of epigenetics on b-cell regeneration for cell replacement therapy, the emerging bioinformatics approaches for analyzing the epigenetic contribution to type 2 diabetes mellitus (T2DM), the epigenetic core of the transgenerational inheritance hypothesis in T2DM, and the epigenetic clinical trials on T2DM. Therefore, prevention or reversion of the epigenetic changes occurring during T2DM development may reduce the individual and societal burden of the disease.

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“…O caju apresenta características importantes do ponto de vista nutricional, contendo cerca de 156 a 378 mg de vitamina C, 14,70 mg de cálcio, 32,55 mg de fósforo e 0,57 mg de ferro, por 100 mL de suco (EMBRAPA, 2004). Possui também elevadas concentrações de polifenóis, como ácidos anacárdicos (TEDONG et al, 2010;OLIVEIRA et al, 2012), que estão sendo pesquisados por envolvimento na prevenção de distúrbios, como câncer, dano oxidativo, inflamação e obesidade (HEMSHEKHAR et al, 2012).…”

Section: Introductionunclassified

Processamento e estabilidade de uma bebida de caju e yacon durante o armazenamento sob refrigeração

Dionísio

Wurlitzer

Pinto

et al. 2017

Braz. J. Food Technol.

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Este é um artigo publicado em acesso aberto (Open Access) sob a licença Creative Commons Attribution, que permite uso, distribuição e reprodução em qualquer meio, sem restrições desde que o trabalho original seja corretamente citado. Processamento e estabilidade de uma bebida de caju e yacon durante o armazenamento sob refrigeração Processing and stability of a beverage composed of cashew apple and yacon under refrigerated storageResumo O objetivo do presente trabalho foi avaliar a estabilidade de uma bebida de caju e yacon durante o armazenamento sob refrigeração. A bebida, composta por polpa de caju e extrato de yacon (proporção 1:1, v/v), foi pasteurizada a 85 °C por 90 segundos e armazenada sob refrigeração (5 °C). No tempo inicial e a cada 45 dias do período de estocagem, foram determinados os teores de compostos bioativos (ácido ascórbico -AA e polifenóis extraíveis totais -PET), a atividade antioxidante total (AAT), os sólidos solúveis totais (SST), a acidez titulável (AT), o pH e a cor (L*, a* e b*). Após 225 dias de estocagem, a bebida apresentou diminuição expressiva da sua AAT, medida pelo método FRAP (Ferric Reducing Antioxidant Power), de aproximadamente 22%, assim como houve queda nas concentrações de AA e PET, em torno de 20 e 16%, respectivamente. A bebida atendeu ao padrão estabelecido pela legislação brasileira para coliformes a 45 °C e Salmonella sp. (ausência/25 mL); porém, em 135 dias de armazenamento, a bebida apresentou contagem de bolores e leveduras superior a 10 4 UFC/mL. Neste sentido, embora a bebida tenha apresentado níveis consideráveis de compostos bioativos e AAT durante os 225 dias de armazenamento refrigerado (5 °C), recomenda-se que o produto seja armazenado por até 90 dias sob refrigeração (5 °C), período em que a bebida manteve seus componentes bioativos e boa qualidade microbiológica e sensorial. Palavras-chave: Smallanthus sonchifolius; Estocagem; Qualidade. AbstractThe objective of the present study was to evaluate the stability of a beverage produced with cashew apple and yacon during refrigerated storage. The beverage, composed of cashew pulp and yacon extract (ratio 1: 1, v / v), was pasteurized at 85 °C for 90 seconds and stored at 5 °C. The following components were evaluated at zero time (after processing and packaging) and every 45 days during the storage period: the bioactive compound contents (ascorbic acid (AA), total extractable polyphenols (PET), total antioxidant activity (AAT), total soluble solids, titratable acidity (AT), pH and colour (L *, a * and b *). After 225 days of storage, the beverage presented a 22% decrease in AAT as analysed by the FRAP method (Ferric Reducing Antioxidant Power), as well as a drop in the AA and PET concentrations of around 20 and 16%, respectively. The beverage complied with the microbiological standard established by Brazilian legislation for coliforms at 45 °C and Salmonella sp. (absence/25 mL), but after 135 days storage, the beverage had a yeast and mould count greater than 10 4 CFU/mL. Thus although the beverage presented ...

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Hydro‐ethanolic extract of cashew tree (Anacardium occidentale) nut and its principal compound, anacardic acid, stimulate glucose uptake in C2C12 muscle cells

Cited by 47 publications

References 35 publications

Magnesium Rich Extract of Cashew Tree (Anacardium Occidentale) Nut and its Principal Compound, Anacardic Acid, Stimulate Glucose Uptake in C2C12 Muscle Cells

Magnesium Rich Extract of Cashew Tree (Anacardium Occidentale) Nut and its Principal Compound, Anacardic Acid, Stimulate Glucose Uptake in C2C12 Muscle Cells

Clinical relevance of epigenetics in the onset and management of type 2 diabetes mellitus

Processamento e estabilidade de uma bebida de caju e yacon durante o armazenamento sob refrigeração

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