Hydrazine selective dual signaling chemodosimetric probe in physiological conditions and its application in live cells

Recent progress in the development of fluorescent probes for hydrazine

“…Das and co‐workers prepared a rhodamine‐cyanobenzene conjugate ( 70 ) for both colorimetric and fluorimetric detection of hydrazine (Figure ) . Hydrazine was speculated to form a hydrogen bonded dimer with 70 affording an electron deficient C=N bond, which may promote the hydrolysis of the probe 70 .…”

Diethyl Malonate-Based Turn-On Chemical Probe for Detecting Hydrazine and Its Bio-Imaging and Environmental Applications With Large Stokes Shift

“…During the last few decades, a series of turn-on probes were applied to detect N 2 H 4 in living biosamples (Cui et al, 2014;Goswami et al, 2014aGoswami et al, ,b, 2015Liu et al, 2014Liu et al, , 2019Qian et al, 2014;Qu et al, 2014;Raju et al, 2014;Sun et al, 2014Sun et al, , 2015Xiao et al, 2014;Jin et al, 2015;Nandi et al, 2015;Yu et al, 2015;Zhang et al, 2015;Dai et al, 2016;Reja et al, 2016;Chen et al, 2017;Li et al, 2017Li et al, , 2018Ma et al, 2017;Mahapatra et al, 2017;Jung et al, 2019;Paul et al, 2019;Shi et al, 2019;Xing et al, 2019;Fang et al, 2020;Han et al, 2020;Hou et al, 2020;Vijay and Velmathi, 2020), a few of which were constructed by cleavage of C = C bond (Sun et al, 2014;Reja et al, 2016;Li et al, 2017Li et al, , 2018Liu et al, 2019;Hou et al, 2020). Many examples were developed by the deprotection group from the fluorescent group (Cui et al, 2014;Goswami et al, 2014aGoswami et al, , 2015Liu et al, 2014;Qian et al, 2014;…”

“…Many examples were developed by the deprotection group from the fluorescent group (Cui et al, 2014;Goswami et al, 2014aGoswami et al, , 2015Liu et al, 2014;Qian et al, 2014;Qu et al, 2014;Raju et al, 2014;Jin et al, 2015;Sun et al, 2015;Yu et al, 2015;Zhang et al, 2015;Chen et al, 2017;Ma et al, 2017;Mahapatra et al, 2017;Shi et al, 2019;Xing et al, 2019;Fang et al, 2020;Vijay and Velmathi, 2020). Additionally, the rest of the fluorescent molecules were used to monitor N 2 H 4 using the property of special nucleophilicity of N 2 H 4 (Goswami et al, 2014b;Xiao et al, 2014;Nandi et al, 2015;Dai et al, 2016;Jung et al, 2019;Paul et al, 2019;Han et al, 2020). That is why it is necessary to construct a powerful molecule for monitoring N 2 H 4 by the way of cleavage of C = C bond.…”

Rational design of a novel turn-on fluorescent probe for the detection and bioimaging of hydrazine with barbituric acid as a recognition group

“…So far, a variety of dyes scaffold have been designed and synthesized for detecting hydrazine based on different responsive mechanism, such as rhodamine [ 17 ], BODIPY [18,19], coumarin [20,21], resorufin [22,23], benzothiazole [24,25], heptamethine cyanine and hemicyanine [ 26 , 27 ]. On the other hand, a lot of fluorescent probes for hydrazine have been reported on the strength of three different mechanisms, including selective reaction with arylidenemalononitrile [ 28 , 29 ], selective deprotection of levulinoyl ester or acetyl groups [30,31,32], condensation with arylaldehydes [33,34], phthalimide [35,36] and 4-bromo butyrate [37,38,39].…”