A novel turn-on fluorescent probe with barbituric acid as a unique recognition group has been rationally designed and synthesized using a facile method for detecting hydrazine.
The detection of ClOis vital to comprehend the accurate effect of ClOin various diseases and therapeutic interventions by fluorescent probe method. Herein, a special ratiometric probe DDD was designed and efficiently synthesized via a simple process for hypochlorite detection. The selectivity and sensitivity of probe DDD was excellent and the detection was not influenced by other reactive oxygen species. Probe DDD exhibited a fast response (< 1 s), wide Stokes Shift (> 100 nm), sensitive limit of detection ( 78nM) and two well-separated emission (555 nm and 635 nm). The emission intensities ratio (I 555 /I 635 ) was linearly enhanced (I 555 /I 635 = 0.6273X -1.9313) with the ClOconcentration range from 4.0 to 20.0 μM. Furthermore, probe DDD has been successfully evaluated in monitoring exogenous HClO in SH-SY5Y neuroblastoma cells and zebrafish larvae with low cytotoxicity, good cell permeability and biocompatibility.
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