Hydration of phosphorylcholine groups attached to highly swollen polymer hydrogels studied by thermal analysis

Morisaku, Toshinori; Watanabe, Junji; Konno, Tomohiro; Takai, Madoka; Ishihara, Kazuhíko

doi:10.1016/j.polymer.2008.08.025

Cited by 123 publications

(97 citation statements)

References 33 publications

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“…The number of water molecules associated with each PC was calculated to be 23 in one study. 6 It is, however, concluded that the water structure surrounding a zwitterion is unperturbed, similar to that of the bulk water. 5 Therefore, water release related entropy change on the liposome surface does not contribute much thermodynamically to its adsorption.…”

Section: Zwitterionic Pc Lipidsmentioning

confidence: 99%

Interfacing Zwitterionic Liposomes with Inorganic Nanomaterials: Surface Forces, Membrane Integrity, and Applications

Liu

2016

Langmuir

118

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Section: Zwitterionic Pc Lipidsmentioning

confidence: 99%

Interfacing Zwitterionic Liposomes with Inorganic Nanomaterials: Surface Forces, Membrane Integrity, and Applications

Liu

2016

Langmuir

118

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“…It was suggested that non-freezing water may play a key role in protein adsorption resistance, and thus lead to increasing biocompatibility of polymeric materials. 26 In our study, the state of water in hydrogels was evaluated using DSC. The representative DSC heating curves are shown in Figure 5.…”

Section: Differential Scanning Calorimetrymentioning

confidence: 99%

Poly(2‐oxazoline) hydrogels crosslinked with aliphatic bis(2‐oxazoline)s: Properties, cytotoxicity, and cell cultivation

Zahoranová

Kroneková

Záhoran

et al. 2015

J. Polym. Sci. Part A: Polym. Chem.

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A series of hydrogels from 2-ethyl-2-oxazoline and three bis(2-oxazoline) crosslinkers-1,4-butylene-2,2 0 -bis(2-oxazoline), 1,6-hexamethylene-2,2 0 -bis(2-oxazoline), and 1,8-octamethylene-2,2 0 -bis(2-oxazoline)-are prepared. The hydrogels differ by the length of aliphatic chain of crosslinker and by the percentage of crosslinker (2-10%). The influence of the type and the percentage of the crosslinker on swelling properties, mechanical properties, and state of water is studied. The equilibrium swelling degree in water ranges from 2 to 20. With a proper selection of the crosslinker, Young's modulus can be varied from 10 kPa to almost 100 kPa. To evaluate the potential for medical applications, the cytotoxicity of extracts and the contact toxicity toward murine fibroblasts are measured. The hydrogels with the crosslinker containing a shorter aliphatic exhibit low toxicity toward fibroblast cells. Moreover, the viability and the proliferation of pancreatic b-cells incubated inside hydrogels for 12 days are analyzed.

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“…Over time, the polymer is hydrolyzed resulting in erosion of the matrix. [8] These PHEMA hydrogels have been shown to be useful for cell immobilization, [9][10][11] coating drug delivery devices for neural micro-electrode arrays, [12] artificial skin, [13] corneal replacements and repairs, [6,14] controlled drug release, [15] and as synthetic articular cartilage. [16,17] Understanding the degradation of PHEMA films is important because both porosity and hydrogel formation depend on how the film degrades over time.…”

Section: Introductionmentioning

confidence: 99%

Cross‐Linking and Degradation Properties of Plasma Enhanced Chemical Vapor Deposited Poly(2‐hydroxyethyl methacrylate)

Pfluger

Carrier

Sun

et al. 2009

Macromol. Rapid Commun.

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Plasma Enhanced Chemical Vapor Deposition (PECVD) of poly-2-hydroxyethyl methacrylate (pHEMA) biocompatible, biodegradable polymer films were produced alone and cross-linked with ethylene glycol diacrylate (EGDA). Degree of cross-linking was controlled via manipulation of the EGDA flow rate, which influenced the amount of swelling and the extent of degradation of the films in an aqueous solution over time. Noncross-linked pHEMA films swelled 10% more than cross-linked films after 24 h of incubation in an aqueous environment. Increasing degree of film cross-linking decreased degradation over time. Thus, PECVD pHEMA films with variable cross-linking properties enable tuning of gel formation and degradation properties, making these films useful in a variety of biologically significant applications.

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Hydration of phosphorylcholine groups attached to highly swollen polymer hydrogels studied by thermal analysis

Cited by 123 publications

References 33 publications

Interfacing Zwitterionic Liposomes with Inorganic Nanomaterials: Surface Forces, Membrane Integrity, and Applications

Interfacing Zwitterionic Liposomes with Inorganic Nanomaterials: Surface Forces, Membrane Integrity, and Applications

Poly(2‐oxazoline) hydrogels crosslinked with aliphatic bis(2‐oxazoline)s: Properties, cytotoxicity, and cell cultivation

Cross‐Linking and Degradation Properties of Plasma Enhanced Chemical Vapor Deposited Poly(2‐hydroxyethyl methacrylate)

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