Hydrated Dynamic Surfaces

Nagaoka, Shin‐ichi; Mori, Yuzo; Tanzawa, Hiroshi; Kikuchi, Yoshinobu; Inagaki, F.; Yokota, Y.; Noishiki, Yasuharu

doi:10.1097/00002480-198704000-00006

Cited by 39 publications

(14 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Copolymers of methoxy-poly(ethylene glycol monomethacrylate) and methyl methacrylate, poly(MPEGMA-co-MMA), also exhibited an excellent blood compatibility at M -n L 4.4 6 10 3 of POE segments both in vitro and in vivo: [33] plasma protein adsorption and platelet adhesion onto the copolymers significantly decreased with increased POE chain length, and very few platelets were observed when the POE chain length approached 100. [34] This finding seems to be caused by the volume restriction effects derived from the highly flexible and hydrophilic POE chains. [35] In order to justify the evaluation of biocompatibility of water soluble polymer by the K m , the enzymatic reaction of thrombin and S-2238 was carried out in the presence of POE with different molecular weight (M -n ).…”

Section: Enzymatic Reaction Of Thrombin and S-2238 In The Presence Ofmentioning

confidence: 99%

Evaluation of biocompatibility of the surface of polyethylene films modified with various water soluble polymers using Ar plasma-post polymerization technique

Sugiyama

Matsumoto

Yamazaki

2000

Macromol. Mater. Eng.

View full text Add to dashboard Cite

Section: Enzymatic Reaction Of Thrombin and S-2238 In The Presence Ofmentioning

confidence: 99%

Evaluation of biocompatibility of the surface of polyethylene films modified with various water soluble polymers using Ar plasma-post polymerization technique

Sugiyama

Matsumoto

Yamazaki

2000

Macromol. Mater. Eng.

View full text Add to dashboard Cite

“…For the materials, blood compatibility is one of the most important properties when they come into contact with blood in their usage. Until now, various polymer surfaces with good blood compatibility have been designed, for instance, the surfaces composed of nonionic hydrophilic polymer,1–4, bio‐membrane‐like polymer,5, 6 and microphase‐separated block copolymer 7, 8. At the same time, a number of mechanisms have been proposed to explain the compatibility of these materials, “for example” one material has one mechanism different from the others.…”

Section: Introductionmentioning

confidence: 99%

Relationship between blood compatibility and water structure—Comparative study between 2‐methoxyethylacrylate‐ and 2‐methoxyethylmethacrylate‐based random copolymers

Hirota¹,

Tanaka

Mochizuki³

2007

J Biomedical Materials Res

View full text Add to dashboard Cite

We have proposed that the excellent blood compatibility of poly(2-methoxyethylacrylate (MEA)) is caused by freezing bound water contained in it on the basis of results on platelet activation (Tanaka and Mochizuki, J Biomed Mater Res A 2004; 68:684-695). To clarify the applicability of this mechanism to other indexes for blood compatibility, the relationship between complement activation and water structure was investigated by using two copolymers, poly(MEA-2-hydroxyethylmethacrylate (HEMA)) and poly(2-methoxyethylmethacrylate (MEMA)-HEMA), where HEMA content was varied from 25 to 90 mol %. ESCA analysis revealed that the surface compositions of these copolymers (dry state) agreed with the compositions determined by (1)H NMR. However, analysis by water contact angle (wet state) showed that their surfaces were quite different. The contact angle of poly(MEMA-HEMA) depended on the monomer composition, whereas the angle of poly(MEA-HEMA) was close to that of polyHEMA regardless of the monomer composition. The effect of HEMA content in the copolymers on complement activation (production of C3a) was investigated in an in vitro test. The activation by poly(MEMA-HEMA) was enhanced according to the HEMA content, while the activation by poly(MEA-HEMA) with 0-40 mol % of HEMA was weak and did not depend on the HEMA content. These properties are discussed from the viewpoints of the water structure observed by DSC and the surface structure.

show abstract

“…Many fundamental and practical researches have been carried out to give excellent blood compatibility to these materials 1. Such efforts created various polymer surfaces with good blood compatibility, for instance, the surfaces composed of nonionic hydrophilic polymer,2–5 biomembrane‐like polymer,6, 7 and microphase‐separated block copolymer 8, 9. To explain the compatibility of these materials, a number of mechanisms have been proposed, because one material has one mechanism different from the others.…”

Section: Introductionmentioning

confidence: 99%

Study on blood compatibility with poly(2‐methoxyethylacrylate)—relationship between surface structure, water structure, and platelet compatibility in 2‐methoxyethylacrylate/2‐hydroxyethylmethacrylate diblock copolymer

Hirota

Ute

Uehara

et al. 2005

J Biomedical Materials Res

View full text Add to dashboard Cite

Diblock copolymers composed of 2-methoxyethylacrylate (MEA) and 2-hydroxyethylmethacrylate (HEMA) were firstly prepared (the composition ratio = 90/10, 79/21, 66/34, and 48/52 mol/mol) by anion living polymerization. ESCA analysis of their surface structures (dry state) revealed that PMEA segment was segregated to the top surface in all of the polymers, whereas the results of contact angle of water (wet state) showed that the surfaces were covered with PHEMA segment. In vitro platelet adhesion test showed that these polymers had the excellent compatibility with platelet compared to PHEMA homopolymer. Water structure in the hydrated copolymers was investigated by DSC and freezing bound water was observed for all the polymers like PMEA homopolymer, whereas it was not found in PHEMA homopolymer. Further investigation of water structure based on the results of DSC and EWCMS (equilibrium water content by moisture sorption) suggested that freezing bound water existed in PHEMA segment in addition to PMEA segment. We have proposed that the water plays a key role in the appearance of good blood compatibility of the copolymer, according to our previous works (Tanaka et al. Biomacromolecules 2002;3:36-41, Tanaka et al. J Biomed Mater Res A 2004;68:684-695).

show abstract

Hydrated Dynamic Surfaces

Cited by 39 publications

References 0 publications

Evaluation of biocompatibility of the surface of polyethylene films modified with various water soluble polymers using Ar plasma-post polymerization technique

Evaluation of biocompatibility of the surface of polyethylene films modified with various water soluble polymers using Ar plasma-post polymerization technique

Relationship between blood compatibility and water structure—Comparative study between 2‐methoxyethylacrylate‐ and 2‐methoxyethylmethacrylate‐based random copolymers

Study on blood compatibility with poly(2‐methoxyethylacrylate)—relationship between surface structure, water structure, and platelet compatibility in 2‐methoxyethylacrylate/2‐hydroxyethylmethacrylate diblock copolymer

Contact Info

Product

Resources

About