SUMMARYIn order to assess clinical and epidemiological aspects, we reviewed 113 clinical records of patients with Gestational trophoblastic disease (GTD) treated at the Gynecology and Obstetrics Department of Hospital Nacional Cayetano Heredia between January 1981 and December 1990. The frequency observed was 2.33 cases of GTD per 1000 pregnancies. The rate was significatively higher than the average in women older than 40 years (22.09 per 1000 deliveries). Vaginal bleeding was the most frequent clinical symptom (90.26%), followed by uterus larger than expected for gestational age (39.82%) and hyperemesis gravidarum (29.20%). Dilatation and curettage was the only surgical treatment used in 76.80% of patients. Three cases of choriocarcinoma were identified, 17 patients showed persistent trophoblastic activity in the post-evacuation follow-up, and in 5 cases radiologic images suspected of pulmonary metastases were evidenced. We found no association between the prognostic factors mentioned in the literature and the persistent trophoblastic activity in these patients. (Rev Med Hered 1994; 5: 180-186).