Hybridized nanoamorphous micellar dispersion using a QbD–DM3 linked rational product design strategy for ritonavir: A BCS IV drug

Understanding the Impact of Multi-factorial Composition on Efficient Loading of the Stable Ketoprofen Nanoparticles on Orodispersible Films Using Box-Behnken Design

“…This can be attributed to the rapid adsorption and self-assembling of the lipophilic part of the Soluplus Ò onto the freshly precipitated KTF nanoparticles and its hydrophilic part extending towards the bulk aqueous medium. 34,39,40 The 2-way interaction between Soluplus Ò and KTF was found to be significant, with a p-value of 0.017 showing a negative impact on the PS. It seems that a lower KTF concentration with the addition of an optimum amount of Soluplus Ò concentration decreases the PS of nanosuspensions.…”

“…56 Additionally, Soluplus Ò and HPMC E15 that are utilized to formulate the stable nanoparticles in an amorphous state may provide effective solubilization due to the micellization and intercalation of polymeric disentanglements, respectively. 34 The combined mechanism of nanonization and amorphization provided a high surface area, a higher surface-to-volume ratio, and high surface free energy of KTF-NP-ODFs as compared to pure KTF.…”

“…KTF-NP was prepared using an anti-solvent precipitation technique adapted from previous studies. 15,34 Initially, KTF was dissolved in ethanol (5.0 mL) and filtered using 0.45 mm Acrodisc Ò filters (Pall Corporation, Port Washington, NY). This was termed the "solvent (S) phase".…”

“…This provides steric stabilization and facilitates a reduction in free energy. 34 Therefore, in this kinetically driven event, the rate of the autonomous organization of an amphiphilic moiety and thermodynamic favored micellar structure may have counterbalanced or offset the effect of stabilization provided by Tween 80. However, Tween 80 remains a multi-functional component to the matrix since it also provides optimum tensile strength to the ODFs and weighs equally important to the system.…”