Hybrid protein-polymer nanoparticles based on P(NVCL-co-DMAEMA) loaded with cisplatin as a potential anti-cancer agent

Viana, Daniel Bragança; Mathieu-Gaedke, Maria; Leão, Nádia Miriceia; Böker, Alexander; Soares, Daniel Crístian Ferreira; Glebe, Ulrich; Tebaldi, Marli Luiza

doi:10.1016/j.jddst.2022.103995

Cited by 6 publications

(7 citation statements)

References 71 publications

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“…In 2022, Viana et al [ 211 ] published the fabrication of protein–polymer conjugated NPs of BSA and thermoresponsive copolymer of N-vinylcaprolactam (NVCL) and N,N-dimethylaminoethyl methacrylate (DMAEMA) with excellent properties to be used in the biomedical field such as drug delivery, and also showing antitumor properties. BSA-P(NVCL-co-DMAEMA) nanoparticles were produced by controlled radical polymerization (CRP) employing grafting-from in aqueous medium using Cu(0)-mediated radical polymerization.…”

Section: Current Chemical and Physical Modifications Of Nanomembranes...mentioning

confidence: 99%

Advances in Functionalization of Bioresorbable Nanomembranes and Nanoparticles for Their Use in Biomedicine

Mohammed-Sadhakathullah,

Paulo-Mirasol,

Torras

et al. 2023

IJMS

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Bioresorbable nanomembranes (NMs) and nanoparticles (NPs) are powerful polymeric materials playing an important role in biomedicine, as they can effectively reduce infections and inflammatory clinical patient conditions due to their high biocompatibility, ability to physically interact with biomolecules, large surface area, and low toxicity. In this review, the most common bioabsorbable materials such as those belonging to natural polymers and proteins for the manufacture of NMs and NPs are reviewed. In addition to biocompatibility and bioresorption, current methodology on surface functionalization is also revisited and the most recent applications are highlighted. Considering the most recent use in the field of biosensors, tethered lipid bilayers, drug delivery, wound dressing, skin regeneration, targeted chemotherapy and imaging/diagnostics, functionalized NMs and NPs have become one of the main pillars of modern biomedical applications.

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Section: Current Chemical and Physical Modifications Of Nanomembranes...mentioning

confidence: 99%

Advances in Functionalization of Bioresorbable Nanomembranes and Nanoparticles for Their Use in Biomedicine

Mohammed-Sadhakathullah,

Paulo-Mirasol,

Torras

et al. 2023

IJMS

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“…Over the last decade, the use of nanocarriers to minimize the side effects of available anticancer drugs and improve therapeutic effect has attracted significant attention. Various nanostructures have been explored as drug carriers, such as liposomes, polymeric nanoparticles, nanogels, mesoporous silica nanoparticles, carbon nanotubes, quantum dots, and magnetic nanoparticles 5–7 . Magnetic nanoparticles (MNs), especially iron oxide nanoparticles (IONPs) have excellent hydrophilicity, biocompatibility, small particle size, low toxicity and unique superparamagnetic properties and have been most widely investigated in the medical fields, such as drug delivery, hyperthermia treatment, and magnetic resonance imaging 8,9 .…”

Section: Introductionmentioning

confidence: 99%

“…Various nanostructures have been explored as drug carriers, such as liposomes, polymeric nanoparticles, nanogels, mesoporous silica nanoparticles, carbon nanotubes, quantum dots, and magnetic nanoparticles. [5][6][7] Magnetic nanoparticles (MNs), especially iron oxide nanoparticles (IONPs) have excellent hydrophilicity, biocompatibility, small particle size, low toxicity and unique superparamagnetic properties and have been most widely investigated in the medical fields, such as drug delivery, hyperthermia treatment, and magnetic resonance imaging. 8,9 However, due to the large surface-to-volume ratio and magnetic dipole-dipole interaction, IONPs tend to agglomerate, which leads to a significant reduction of their circulation time in the body.…”

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confidence: 99%

Shell‐sheddable and charge switchable magnetic nanoparticle as pH‐sensitive nanocarrier for targeted drug delivery applications

Aram,

Sadeghi‐Abandansari,

Radmanesh

et al. 2024

Polymers for Advanced Techs

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A pH‐sensitive shell‐sheddable magnetic nanocarrier was prepared based on Fe3O4@SiO2 nanoparticles coated with polyethyleneimine (PEI) and polyethyleneglycol (PEG). The PEI was coated on Fe3O4@SiO2 nanoparticles through an electrostatic attraction and the PEG chains were connected to the PEI via pH‐sensitive benzoic‐imine bonds. The synthesized products and final nanocarrier were characterized with FT‐IR, 1H NMR, dynamic light scattering (DLS), zeta‐potential, TEM, and vibrating‐sample magnetometer (VSM). The PEI, as a middle layer, was used to load the curcumin (an anticancer drug) via van der Waals interactions and the shedding of PEG as a hydrophilic corona at the tumor pH (acidic) could induce the release of the drug. The curcumin loading content was found to be ~15% and curcumin‐loaded magnetic nanoparticles (C‐LMNs) showed more triggered release at the tumor pH (5.6) than physiological pH (7.4). In comparison to pure magnetic nanoparticles (MNs), the C‐LMNs showed more cytotoxicity to human prostate cancer cell (PC‐3) and also resulted in an increased rate of late apoptotic/necrotic PC‐3 cells, assessed by flow cytometry analysis. In conclusion, the C‐LMN as pH‐ and magnetic responsive nanocarrier showed good potential for targeted curcumin delivery in therapy of prostate cancer.

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“…Among the currently known cationic polymers used for gene delivery, there are a small number of polymers, such as chitosan, poly(2-(N, N -dimethylamino)ethyl methacrylate), polyethyleneimine, which provide effective targeted delivery of DNA plasmids and are, at the same time, substances that affect the cell membrane [ 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 ]. It should be noted that cationic polyelectrolytes with a high charge density also have high cytotoxicity, which can be reduced by introducing polyethylene glycol (polyethylene oxide—PEO), which has good water solubility and biocompatibility, into their composition.…”

Section: Introductionmentioning

confidence: 99%

Promising Gene Delivery Properties of Polycations Based on 2-(N,N-dimethylamino)ethyl Methacrylate and Polyethylene Glycol Monomethyl Ether Methacrylate Copolymers

et al. 2023

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Cationic copolymers based on 2-(N,N-dimethylamino)ethyl methacrylate and polyethylene glycol monomethyl ether (pDMAEMA-co-PEO) with different molecular weights have been synthesized. Their physicochemical properties were studied by NMR spectroscopy, sedimentation, and potentiometric titration. According to the data of potentiometric titration for the synthesized pegylated cationic copolymers, the apparent dissociation constants were determined in the pH range from 4.5 to 8.5. The physicochemical properties of interpolyelectrolyte complexes of these polycations with circular DNA (IPEC DNA) were also studied by dynamic light scattering, electrophoretic mobility, and TEM methods. It has been established that the diameter and electrokinetic potential (ζ-potential) of interpolyelectrolyte complexes can be varied over a wide range (from 200 nm to 1.5 μm and from −25 mV to +30 mV) by changing the ratio of oppositely charged ionizable groups in pegylated cationic copolymers and DNA, as well as by regulating medium pH. The resistance of the IPEC DNA/polycation complex to the action of nucleases was studied by electrophoresis in agarose gel; the cytotoxic effect of the polymers in vitro, and the efficiency of penetration (transfection) of IPEC DNA with PDMAEMA-co-PEO-polycations into eukaryotic cells of a cell line derived from human embryonic kidneys HEK 293 in vitro.

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Hybrid protein-polymer nanoparticles based on P(NVCL-co-DMAEMA) loaded with cisplatin as a potential anti-cancer agent

Cited by 6 publications

References 71 publications

Advances in Functionalization of Bioresorbable Nanomembranes and Nanoparticles for Their Use in Biomedicine

Advances in Functionalization of Bioresorbable Nanomembranes and Nanoparticles for Their Use in Biomedicine

Shell‐sheddable and charge switchable magnetic nanoparticle as pH‐sensitive nanocarrier for targeted drug delivery applications

Promising Gene Delivery Properties of Polycations Based on 2-(N,N-dimethylamino)ethyl Methacrylate and Polyethylene Glycol Monomethyl Ether Methacrylate Copolymers

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