Hybrid PCL/CaCO3 scaffolds with capabilities of carrying biologically active molecules: Synthesis, loading and in vivo applications

Saveleva, Mariia; Ivanov, AN; Kurtukova, M. O.; Atkin, VS; Иванова, А. Г.; Lyubun, G. P.; Martyukova, A V; Cherevko, EI; Sargsyan, AK; Fedonnikov, Alexander S.; Норкин, И. А.; Skirtach, André G.; Gorin, Dmitry A.; Parakhonskiy, Bogdan

doi:10.1016/j.msec.2017.12.019

Cited by 47 publications

(41 citation statements)

References 57 publications

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“…Saveleva et al recently tested a PCL/CaCO 3 scaffold loaded with tannic acid as a model substance in vivo and demonstrated benecial effects of the implanted scaffold on the stabilisation of blood vessels in rats by the release of loaded drugs, which, in turn, was induced by the recrystallisation of vaterite to calcite. 28 It was also shown that the introduction of vaterite particles as a ller or coating onto polymer scaffolds induced the biomimetic precipitation of HAp from simulated body uid. 21,29 A number of studies demonstrated that the nucleation and growth processes of CaCO 3 crystals are affected by the microenvironment.…”

Section: Introductionmentioning

confidence: 99%

Effect of low-temperature plasma treatment of electrospun polycaprolactone fibrous scaffolds on calcium carbonate mineralisation

et al. 2018

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Section: Introductionmentioning

confidence: 99%

Effect of low-temperature plasma treatment of electrospun polycaprolactone fibrous scaffolds on calcium carbonate mineralisation

et al. 2018

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“…This has been shown for both small drugs (e.g. tannic acid releasing for weeks 122 ) and biomacromolecule RNase. 123 Most of the CaCO 3 -based scaffolds are composites made of polymer hydrogels with VCC crystals embedded into polymer networks and either homogeneously distributed inside gels 123,124 or representing coatings, e.g.…”

Section: Vcc For Tissue Engineeringmentioning

confidence: 80%

Naturally derived nano- and micro-drug delivery vehicles: halloysite, vaterite and nanocellulose

et al. 2020

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“…A striking example of a solution to this problem is the work of Savelyeva et al They coated PCL nanofibers by CaCO3 particles loaded tannic acid. It was reported that particles improve cell adhesion on the surface of the PCL implant, and when connected to the bone, after a while passed into the form of hydroxyapatite, which significantly improved the integration of the implant on both sides [138] ( Figure 2). It is these aspects that limit the use of pure polymers for tissue engineering prompting to use of hybrid materials, which are overall better suited for fine-tuning of relevant properties of implants [131], and can be also used for drug delivery through incorporated particles.…”

Section: Hybrid Biomaterials Applied For Tendonmentioning

confidence: 98%

Section: Hybrid Biomaterials Applied For Tendonmentioning

confidence: 98%

“…One solution to this potential problem is a modification of polymer hydrogels and fibers by microcontainers or microcapsules with, for example, tannic acid, which has antimicrobial properties. This would resist fibrosis and would improve angiogenesis of tissues [138,148,150,151]. It should be noted that signals generated by VEGF and TGF play an important role for proper regeneration of skin tissue and healing of wounds [144,147,152,153].…”

Section: Hybrid Biomaterials Applied For Skinmentioning

confidence: 99%

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Polymer- and Hybrid-Based Biomaterials for Interstitial, Connective, Vascular, Nerve, Visceral and Musculoskeletal Tissue Engineering

2020

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In this review, materials based on polymers and hybrids possessing both organic and inorganic contents for repairing or facilitating cell growth in tissue engineering are discussed. Pure polymer based biomaterials are predominantly used to target soft tissues. Stipulated by possibilities of tuning the composition and concentration of their inorganic content, hybrid materials allow to mimic properties of various types of harder tissues. That leads to the concept of "one-matches-all" referring to materials possessing the same polymeric base, but different inorganic content to enable tissue growth and repair, proliferation of cells, and the formation of the ECM (extra cellular matrix). Furthermore, adding drug delivery carriers to coatings and scaffolds designed with such materials brings additional functionality by encapsulating active molecules, antibacterial agents, and growth factors. We discuss here materials and methods of their assembly from a general perspective together with their applications in various tissue engineering sub-areas: interstitial, connective, vascular, nervous, visceral and musculoskeletal tissues. The overall aims of this review are two-fold: (a) to describe the needs and opportunities in the field of bio-medicine, which should be useful for material scientists, and (b) to present capabilities and resources available in the area of materials, which should be of interest for biologists and medical doctors.Polymers 2020, 12, 620 2 of 30 allows to tailor functionalize the coatings, where their responsiveness to external stimuli is one of their biggest advantages.Polymers stand out as a special class of materials due to the flexibility of design of their blocks and various functionalities, which is brought by their versatile assembly or by introducing additional side-groups or blocks, in the case of block-co-polymers. In this regard, both synthetic and biocompatible polymers are available, and polymer engineering represents a growing area tailoring the needs often driven by applications. With all advantages and the flexibility of the design, there is one significant weakness of polymers-the softness. In regard with tissue engineering, that translates to the fact that some materials can match predominantly soft tissue, but it is difficult to tune mechanical properties of polymers to match the hardness of bones, tendons, etc. And since mechanical properties of materials affect and even drive cell and tissue growth, enhancement of mechanical properties of polymers and biomaterials is essential. Chemical crosslinking can be applied to address these challenges, but that solves problems only partially.To solve these challenges the so-called hybrid materials [6] are used, which possess both inorganic and organic contents. Increasingly, hybrid materials are used in designing the extracellular matrix. The hybrid matrix design for various tissue engineering applications should meet bio-medical requirements. On the one hand, it needs to be biocompatible and biodegradable, which is achieved through the po...

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Hybrid PCL/CaCO3 scaffolds with capabilities of carrying biologically active molecules: Synthesis, loading and in vivo applications

Cited by 47 publications

References 57 publications

Effect of low-temperature plasma treatment of electrospun polycaprolactone fibrous scaffolds on calcium carbonate mineralisation

Effect of low-temperature plasma treatment of electrospun polycaprolactone fibrous scaffolds on calcium carbonate mineralisation

Naturally derived nano- and micro-drug delivery vehicles: halloysite, vaterite and nanocellulose

Polymer- and Hybrid-Based Biomaterials for Interstitial, Connective, Vascular, Nerve, Visceral and Musculoskeletal Tissue Engineering

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