Hybrid of Resveratrol and Glucosamine: An Approach To Enhance Antioxidant Effect against DNA Oxidation

Bao, Liang-Liang; Liu, Zai‐Qun

doi:10.1021/acs.chemrestox.8b00136

Cited by 10 publications

(8 citation statements)

References 39 publications

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“…DNA is one of primary targets of radical‐induced oxidative damage, and its damage is generally associated with human diseases. [ 33 ] The protection potential of AG against radical‐induced DNA oxidation was evaluated in vitro using the pBR322 plasmid DNA nicking assay. [ ] The results indicate that AG has relative weaker inhibition than trolox against AAPH‐induced oxidative damage on DNA.…”

Section: Discussionmentioning

confidence: 99%

Efficiency comparison of apigenin-7-O-glucoside and trolox in antioxidative stress and anti-inflammatory properties

Wang

Yue

Jin

et al. 2020

Journal of Pharmacy and Pharmacology

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Objectives Chamomile has long been used as a medicinal plant due to its antioxidative and anti-inflammatory activity. Apigenin-7-O-glucoside (AG) is one of the major ethanol extract components from chamomile; however, the underlying mechanism remains unclear. Methods In this study, the antioxidant potential and the anti-inflammatory activities of AG were analysed and compared with those of trolox. We demonstrate the protective effects of AG on free radical-induced oxidative damage of DNA, proteins and erythrocytes. Flow cytometry assay was used to detect ROS production. Additionally, the expression of anti-oxidation-related and inflammation-related factors was detected by ELISA and Western blotting, respectively. Key findings AG and trolox showed different efficiency as antioxidant in different experimental systems. AG had similar effect as trolox to inhibit H 2 O 2-induced ROS production in RAW264.7 cells, while exerted stronger inhibition against free radical-induced oxidative damage on erythrocytes than trolox. Interestingly, compared with trolox, AG also had stronger inhibitory effect on LPS-induced NF-κB/NLRP3/caspase-1 signalling in RAW246.7 cells. Conclusions These results suggest the potential of AG as a pharmaceutical drug for anti-oxidation and anti-inflammation, and the combined usage of AG and trolox might promote its efficacy. Our findings will provide new insights into the development of new drugs with antioxidative and anti-inflammatory functions.

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Section: Discussionmentioning

confidence: 99%

Efficiency comparison of apigenin-7-O-glucoside and trolox in antioxidative stress and anti-inflammatory properties

Wang

Yue

Jin

et al. 2020

Journal of Pharmacy and Pharmacology

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“…Glucosamine sulphate also effectively reduced the intracellular ROS level in chondrocytes SW1353 cells as measured by dichlorodihydrofluorescein diacetate assay [71]. The novel glucosamine-zinc (II) complex [75] and resveratrol-glucosamine hybrid [76] exhibit promising antioxidant activities.…”

Section: Antioxidant Properties Of Glucosaminementioning

confidence: 95%

Multifaceted Protective Role of Glucosamine against Osteoarthritis: Review of Its Molecular Mechanisms

et al. 2019

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Osteoarthritis (OA) is a joint disease resulting from cartilage degeneration and causing joint pain and stiffness. Glucosamine exerts chondroprotective effects and effectively reduces OA pain and stiffness. This review aims to summarise the mechanism of glucosamine in protecting joint health and preventing OA by conducting a literature search on original articles. Current evidence has revealed that glucosamine exhibits anti-inflammatory effects by reducing the levels of pro-inflammatory factors (such as tumour necrosis factor-alpha, interleukin-1, and interleukin-6) and enhancing the synthesis of proteoglycans that retard cartilage degradation and improve joint function. Additionally, glucosamine improves cellular redox status, reduces OA-mediated oxidative damages, scavenges free radicals, upregulates antioxidant proteins and enzyme levels, inhibits the production of reactive oxygen species, and induces autophagy to delay OA pathogenesis. In conclusion, glucosamine prevents OA and maintains joint health by reducing inflammation, improving the redox status, and inducing autophagy in joints. Further studies are warranted to determine the synergistic effect of glucosamine with other anti-inflammatory and/or antioxidative agents on joint health in humans.

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“…In an attempt to obtain in vivo rapid metabolization and reduction while maintaining or enhanced biological specificity, several groups have attempted to derivatize resveratrol. This includes several monoalkoxy, dialkoxy, and hydroxy analogs of resveratrol that have been observed to be more effective in activation of PKCα; [47,48] mono, di, and tri-acetoxy resveratrol(s) were more effective at in vitro inhibition of CYP3A4 [48]; other resveratrol-conjugates for inhibition of MMP-9, DNA damage, and activation of p53-p21 CIP1/WAF1 [49][50][51] and recently by our group the effects of aspirin-resveratrol fusions [23,24].…”

Section: Salicylate Derivatives Of Resveratrol Reveal Promising Biolomentioning

confidence: 99%

Resveratrol and Resveratrol-Aspirin Hybrid Compounds as Potent Intestinal Anti-Inflammatory and Anti-Tumor Drugs

et al. 2020

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Resveratrol (3,4,5-Trihydroxy-trans-stilbene) is a naturally occurring polyphenol that exhibits beneficial pleiotropic health effects. It is one of the most promising natural molecules in the prevention and treatment of chronic diseases and autoimmune disorders. One of the key limitations in the clinical use of resveratrol is its extensive metabolic processing to its glucuronides and sulfates. It has been estimated that around 75% of this polyphenol is excreted via feces and urine. To possibly alleviate the extensive metabolic processing and improve bioavailability, we have added segments of acetylsalicylic acid to resveratrol in an attempt to maintain the functional properties of both. We initially characterized resveratrol-aspirin derivatives as products that can inhibit cytochrome P450 Family 1 Subfamily A Member 1 (CYP1A1) activity, DNA methyltransferase (DNMT) activity, and cyclooxygenase (COX) activity. In this study, we provide a detailed analysis of how resveratrol and its aspirin derivatives can inhibit nuclear factor kappa B (NFκB) activation, cytokine production, the growth rate of cancer cells, and in vivo alleviate intestinal inflammation and tumor growth. We identified resveratrol derivatives C3 and C11 as closely preserving resveratrol bioactivities of growth inhibition of cancer cells, inhibition of NFκB activation, activation of sirtuin, and 5’ adenosine monophosphate-activated protein kinase (AMPK) activity. We speculate that the aspirin derivatives of resveratrol would be more metabolically stable, resulting in increased efficacy for treating immune disorders and as an anti-cancer agent.

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Hybrid of Resveratrol and Glucosamine: An Approach To Enhance Antioxidant Effect against DNA Oxidation

Cited by 10 publications

References 39 publications

Efficiency comparison of apigenin-7-O-glucoside and trolox in antioxidative stress and anti-inflammatory properties

Efficiency comparison of apigenin-7-O-glucoside and trolox in antioxidative stress and anti-inflammatory properties

Multifaceted Protective Role of Glucosamine against Osteoarthritis: Review of Its Molecular Mechanisms

Resveratrol and Resveratrol-Aspirin Hybrid Compounds as Potent Intestinal Anti-Inflammatory and Anti-Tumor Drugs

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