Hybrid nanostructured coating for increased resistance of prosthetic devices to staphylococcal colonization

Abstract

Prosthetic medical device-associated infections are responsible for significant morbidity and mortality rates. Novel improved materials and surfaces exhibiting inappropriate conditions for microbial development are urgently required in the medical environment. This study reveals the benefit of using natural Mentha piperita essential oil, combined with a 5 nm core/shell nanosystem-improved surface exhibiting anti-adherence and antibiofilm properties. This strategy reveals a dual role of the nano-oil system; on one hand, inhibiting bacterial adherence and, on the other hand, exhibiting bactericidal effect, the core/shell nanosystem is acting as a controlled releasing machine for the essential oil. Our results demonstrate that this dual nanobiosystem is very efficient also for inhibiting biofilm formation, being a good candidate for the design of novel material surfaces used for prosthetic devices.

Mathematical model for ciliary-induced transport in MHD flow of Cu-H 2 O nanofluids with magnetic induction

“…Bég et al [8] used Nakamura finite difference and MAPLE software to study rheological bioconvection in nanofluid boundary layer flow in permeable media as a simulation of near-wall transport in microbial nano-fuel cells. Further investigations of nanofluids in biomedical applications include Anghel and Grumezescu [9] who have demonstrated the excellent bacterial adherence (biofilm) inhibiting characteristics of nanofluid oils in the smart design of novel material surfaces for prosthetic devices. Other analytical articles considering nanofluid dynamics in medicine include Ebaid and Aly [10] for peristaltic flows, Akbar et al [11] for curved tube peristaltic transport of copper nanofluids, Saurin et al [12] for ionic nanofluid bio-lubrication systems (hip joints), Bég et al [13] for swirling mixing systems in nano-biopolymers and very recently Uddin et al [14] for gyrotactic bioconvection in slip Sakiadis flows of nano-polymer sheet manufacturing processes.…”

Magnetite Nanostructures

“…Natural Mentha piperita essential oil combined with a 5-nm core/shell nanosystem-improved surface also proved anti-adherence and antibiofilm properties (Anghel and Grumezescu, 2013). This nanosystem acts as a controlled release machine for the essential oil and is very efficient for inhibiting biofilm formation; it is a good candidate for the design of novel material surfaces used for prosthetic devices (Anghel and Grumezescu, 2013;Anghel et al, 2013b).…”

“…This nanosystem acts as a controlled release machine for the essential oil and is very efficient for inhibiting biofilm formation; it is a good candidate for the design of novel material surfaces used for prosthetic devices (Anghel and Grumezescu, 2013;Anghel et al, 2013b).…”

“…Vegetal extracts and essential oils have been extensively used in traditional medicine for treating infections (WHO, 2002). Recent studies revealed the great impact of mixture extracts and pure compounds obtained from Angiosperms and Gymnosperms to impair bacteria growth and also to modulate their virulence and resistance (Saviuc et al, 2013;Anghel and Grumezescu, 2013;Anghel et al, 2013a). Despite their proven role, studies revealed that natural compounds usually have low stability, and the technical procedures necessary for their testing and use significantly reduce their antimicrobial effect, especially when used in low doses (Holban et al, 2014b).…”

Efficient surface functionalization of wound dressings by a phytoactive nanocoating refractory to Candida albicans biofilm development

“…Functionalized magnetite particles (FMNPs) are being used in an increasing number of biomedical applications [18,19], offering chemical groups designed to permit the specific attachment of drugs and to improve their biocompatibility Recently, a 5 nm average diameter core/shell nanosystem exposing to the surface Mentha piperita EO molecules was reported to exhibit anti-adherent and anti-biofilm properties [20].…”