Magnetite Nanostructures

Holban, Alina Maria; Grumezescu, Alexandru Mihai; Iordache, Florin

doi:10.1016/b978-0-12-801317-5.00004-9

Cited by 1 publication

(1 citation statement)

References 55 publications

(43 reference statements)

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“…UA is one of the four main lichen secondary metabolites with a plethora of biomedical and pharmaceutical properties, including antimicrobial, antitumor, antioxidant, analgesic, anti-inflammatory, and UV-protective effects [ 13 , 39 ]. While studies generally focused on UA efficacy against a wide spectrum of microbial species, i.e., Gram-positive and Gram-negative bacteria [ 40 , 41 , 42 , 43 , 44 , 45 , 46 ], viruses [ 47 , 48 , 49 , 50 ], fungi [ 51 , 52 , 53 ], and protozoa [ 54 ], recent trends have shifted towards its use in anticancer therapy due to demonstrated antiproliferative and cytotoxic effects against numerous cancer cell lines [ 39 , 55 ]. In this context, literature reports numerous studies focusing on the application of UA in cancer treatment using both nano- and microscaled drug delivery systems, such as liposomes, nanoemulsions, polymeric nanocapsules, nanospheres, nanofibers, microspheres, nanodiamonds, and magnetic nanoparticles [ 56 ].…”

Section: Discussionmentioning

confidence: 99%

Usnic Acid-Loaded Magnetite Nanoparticles—A Comparative Study between Synthesis Methods

Chircov,

Bîrcă,

Dănciulescu

et al. 2023

Molecules

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Since cancer is a continuously increasing concern for the general population, more efficient treatment alternatives ought to be developed. In this regard, a promising direction is represented by the use of magnetite nanoparticles (MNPs) to act both as a nanocarrier for the targeted release of antitumoral drugs and as hyperthermia agents. Thus, the present study focused on improving the control upon the outcome properties of MNPs by using two synthesis methods, namely the co-precipitation and microwave-assisted hydrothermal method, for the incorporation of usnic acid (UA), a natural lichen-derived metabolite with proven anticancer activity. The obtained UA-loaded MNPs were thoroughly characterized regarding their morpho-structural and physicochemical properties through X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FT-IR), dynamic light scattering (DLS) and zeta potential, scanning electron microscopy (SEM), and vibrating sample magnetometry (VSM). Results demonstrated the formation of magnetite as the unique mineralogical phase through both types of synthesis, with increased uniformity regarding the drug loading efficiency, size, stability, and magnetic properties obtained through the microwave-assisted hydrothermal method. Furthermore, the cytotoxicity of the nanostructures against the HEK 293T cell line was investigated through the XTT assay, which further proved their potential for anticancer treatment applications.

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