Hybrid Magnetic Hydrogel: A Potential System for Controlled Drug Delivery by Means of Alternating Magnetic Fields

Giani, Gabriele; Fedi, Serena; Barbucci, Rolando

doi:10.3390/polym4021157

Cited by 72 publications

(56 citation statements)

References 32 publications

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“…[46,47,49,50,116,117] Herein, magnetic particles can serve as either solely magnetic components for magnetism integration, or dual roles for both magnetism integration and crosslinkers promoting gelation. For example, Zhang et al [46] dispersed carboxy-modified Fe 3 O 4 nanoparticles in chitosan solution to form a stable ferrofluid at first, followed by the addition of the telechelic difunctional poly(ethylene glycol) (DF-PEG) to proceed Schiff reaction between chitosan and DF-PEG for crosslinking (Figure 11b).…”

Section: Preparation Of Hydrogel-based 3d-spmasmentioning

confidence: 99%

“…[54] The excellent biocompatibility of hydrogels allowed their diverse applications in biological areas. The magnetism [49,54,116,117,[136][137][138][139] In this field, the remotely heatable property of magnetic nanoparticles (MNPs) is frequently used. In detail, the MNPs can generate heat locally under the external AMF due to the hysteretic losses as characterized by M-H diagrams, [51] which was just like the energy dissipation behavior in sponges under compression cycles.…”

Section: Hydrogel-based 3d-spmas For Other Applicationsmentioning

confidence: 99%

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3D Self‐Supporting Porous Magnetic Assemblies for Water Remediation and Beyond

Zhao

Zheng

et al. 2016

Advanced Energy Materials

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In the past few years, three‐dimensional self‐supporting porous magnetic assemblies (3D‐SPMAs) have emerged as a new research area in materials science because of their combined features of three‐dimensional self‐supporting porous assemblies (3D‐SPAs) and magnetic materials. Due to these attributes, 3D‐SPMAs gain numerous tempting properties such as magnetism‐induced actuating, magnetic shape memory effects, and alternative magnetic field (AMF) induced heat generation, showcasing huge potential in diverse applications stretching over water remediation, actuators, biomedical therapy, etc. Especially, 3D‐SPMAs displayed eminent potential in water remediation for their large processing capacity, remote controllability, and magnetic‐field‐mediated wettability. With the rising interest in 3D‐SPAs, the increasing understanding of magnetic materials, and the flourish of materials preparation technique, an upsurge has appeared in 3D‐SPMAs and thus managing them a class of emerging and promising functional materials. However, currently there are rarely review papers concerning 3D‐SPMAs. In this light, this review aims to express a comprehensive overview of this young field and fuel further innovations for preparation methods and practical applications of 3D‐SPMAs. The focus is placed on the synthetic strategies and applications especially in water remediation. The potential opportunities and challenges are also discussed.

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Section: Preparation Of Hydrogel-based 3d-spmasmentioning

confidence: 99%

Section: Hydrogel-based 3d-spmas For Other Applicationsmentioning

confidence: 99%

3D Self‐Supporting Porous Magnetic Assemblies for Water Remediation and Beyond

Zhao

Zheng

et al. 2016

Advanced Energy Materials

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“…Future studies could be done on hybrid hydrogel system with synthetic polyelectrolyte and ECM proteins such as collagen or gelatin. respond to magnetic field, resulting in hydrogel deformation [91] . As shown in Figure 4, magnetic hydrogels can be fabricated through simple blending, or in situ precipitation, or grafting-onto method.…”

Section: Electric Field Responsive Hydrogelmentioning

confidence: 99%

Smart hydrogels for 3D bioprinting

Wang¹,

Lee²,

Yeong³

2015

ijb

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Hydrogels are 3D networks that have a high water content. They have been widely used as cell carriers and scaffolds in tissue engineering due to their structural similarities to the natural extracellular matrix. Among these, "Smart" hydrogels refer to a group of hydrogels that is responsive to various external stimuli such as pH, temperature, light, electric, and magnetic field. Combining the potential of 3D printing and smart hydrogels is an exciting new paradigm in the fabrication of a functional 3D tissue. In this article, we provide a state-of-the-art review on smart hydrogels and bioprinting. We identify the critical material properties needed for the most commonly used bioprinting techniques, namely extrusion-based, inkjet-based, and laser-based techniques. The latest progress in different smart hydrogel systems and their applications in bioprinting are presented. The challenges of printing these hydrogel systems are also highlighted. Lastly, we present the potentials and the future perspectives of smart hydrogels in 3D bioprinting.

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“…One approach currently being explored to meet these requirements is the use of smart materials, i.e., materials that are able to change their shape, mechanical strength and permeability in response to external or physiological stimuli [117] . Smart hydrogels can respond to changes in pH [122] , temperature [123] and electric and magnetic fields [124,125] . These materials are particularly attractive as the scaffold could mould itself as the cells mature.…”

Section: Future Directionsmentioning

confidence: 99%

3D bioprinting for tissue engineering: Stem cells in hydrogels

Mehrban¹,

Teoh²,

Birchall³

2015

ijb

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Surgical limitations require alternative methods of repairing and replacing diseased and damaged tissue. Regenerative medicine is a growing area of research with engineered tissues already being used successfully in patients. However, the demand for such tissues greatly outweighs the supply and a fast and accurate method of production is still required. 3D bioprinting offers precision control as well as the ability to incorporate biological cues and cells directly into the material as it is being fabricated. Having precise control over scaffold morphology and chemistry is a significant step towards controlling cellular behaviour, particularly where undifferentiated cells, i.e., stem cells, are used. This level of control in the early stages of tissue development is crucial in building more complex systems that morphologically and functionally mimic in vivo tissue. Here we review 3D printing hydrogel materials for tissue engineering purposes and the incorporation of cells within them. Hydrogels are ideal materials for cell culture. They are structurally similar to native extracellular matrix, have a high nutrient retention capacity, allow cells to migrate and can be formed under mild conditions. The techniques used to produce these materials, as well as their benefits and limitations, are outlined.

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Hybrid Magnetic Hydrogel: A Potential System for Controlled Drug Delivery by Means of Alternating Magnetic Fields

Cited by 72 publications

References 32 publications

3D Self‐Supporting Porous Magnetic Assemblies for Water Remediation and Beyond

3D Self‐Supporting Porous Magnetic Assemblies for Water Remediation and Beyond

Smart hydrogels for 3D bioprinting

3D bioprinting for tissue engineering: Stem cells in hydrogels

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