Hybrid folic acid-conjugated gold nanorods-loaded human serum albumin nanoparticles for simultaneous photothermal and chemotherapeutic therapy

Encinas-Basurto, David; Ibarra, Jaime; Juárez, Josué; Pardo, Alberto; Barbosa, Sílvia; Taboada, Pablo; Váldez, Miguel A.

doi:10.1016/j.msec.2018.06.002

Cited by 21 publications

(12 citation statements)

References 54 publications

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“…Free DTX was also incorporated to different extents within the protein NPs when corresponding as mentioned above, to provide the nanoplatform with dual chemotherapeutic activity (see Additional file 1 for further details on DTX loading, and resulting nanocarrier characterization). Finally, an 8-carbon side-chain hydrophobically-modified chitosan previously synthesized in the group [33–38] was adsorbed onto the hybrid HSA NPs to provide the resulting platform with further colloidal stability and cationic electric surface charge. The hydrophobic side chains of the formed chitosan shell may favor larger cell affinities compared to nanocarriers, which only exploit ionic interactions for cell attachment [39].…”

Section: Resultsmentioning

confidence: 99%

“…Human serum albumin nanocapsules were prepared by a conventional desolvation method with some modifications, as previously reported [33]. First, a HSA stock solution (20 mg/mL pH 5.5) was made: 5 mg of HSA were mixed with 500 µL of pure ethanol to prepare bare HSA NPs (or with 500 µL of PSS-coated (1·10 11 NP/mL), or PSS/DOXO-coated GNRs (1·10 11 NP/mL) as corresponding) at 830 rpm.…”

Section: Methodsmentioning

confidence: 99%

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Combination of light-driven co-delivery of chemodrugs and plasmonic-induced heat for cancer therapeutics using hybrid protein nanocapsules

et al. 2019

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Background Improving the water solubility of hydrophobic drugs, increasing their accumulation in tumor tissue and allowing their simultaneous action by different pathways are essential issues for a successful chemotherapeutic activity in cancer treatment. Considering potential clinical application in the future, it will be promising to achieve such purposes by developing new biocompatible hybrid nanocarriers with multimodal therapeutic activity. Results We designed and characterised a hybrid nanocarrier based on human serum albumin/chitosan nanoparticles (HSA/chitosan NPs) able to encapsulate free docetaxel (DTX) and doxorubicin-modified gold nanorods (DOXO-GNRs) to simultaneously exploit the complementary chemotherapeutic activities of both antineoplasic compounds together with the plasmonic optical properties of the embedded GNRs for plasmonic-based photothermal therapy (PPTT). DOXO was assembled onto GNR surfaces following a layer-by-layer (LbL) coating strategy, which allowed to partially control its release quasi-independently release regarding DTX under the use of near infrared (NIR)-light laser stimulation of GNRs. In vitro cytotoxicity experiments using triple negative breast MDA-MB-231 cancer cells showed that the developed dual drug encapsulation approach produces a strong synergistic toxic effect to tumoral cells compared to the administration of the combined free drugs; additionally, PPTT enhances the cytostatic efficacy allowing cell toxicities close to 90% after a single low irradiation dose and keeping apoptosis as the main cell death mechanism. Conclusions This work demonstrates that by means of a rational design, a single hybrid nanoconstruct can simultaneously supply complementary therapeutic strategies to treat tumors and, in particular, metastatic breast cancers with good results making use of its stimuli-responsiveness as well as its inherent physico-chemical properties.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Combination of light-driven co-delivery of chemodrugs and plasmonic-induced heat for cancer therapeutics using hybrid protein nanocapsules

et al. 2019

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“…Biomedical applications involving AuNPs are mainly based on nanoparticles with spherical,22,39,44,111–113 nanorod,12,68,107,114–118 nanoprism5,119,120 and nanocluster geometry;6,121–125 however, current synthetic methods allow for the development of nanoparticles with different morphologies. Morphological changes can also modulate the physicochemical properties of AuNPs, which in combination with SA may be improved and exploited for therapeutic applications.…”

Section: Biomedical Applications Of Albumin-aunpsmentioning

confidence: 99%

<p>Capping gold nanoparticles with albumin to improve their biomedical properties</p>

Bolaños

Kogan

Araya

2019

IJN

133

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Nanotechnology is an emerging field which has created great opportunities either through the creation of new materials or by improving the properties of existing ones. Nanoscale materials with a wide range of applications in areas ranging from engineering to biomedicine have been produced. Gold nanoparticles (AuNPs) have emerged as a therapeutic agent, and are useful for imaging, drug delivery, and photodynamic and photothermal therapy. AuNPs have the advantage of ease of functionalization with therapeutic agents through covalent and ionic binding. Combining AuNPs and other materials can result in nanoplatforms, which can be useful for biomedical applications. Biomaterials such as biomolecules, polymers and proteins can improve the therapeutic properties of nanoparticles, such as their biocompatibility, biodistribution, stability and half-life. Serum albumin is a versatile, non-toxic, stable, and biodegradable protein, in which structural domains and functional groups allow the binding and capping of inorganic nanoparticles. AuNPs coated with albumin have improved properties such as greater compatibility, bioavailability, longer circulation times, lower toxicity, and selective bioaccumulation. In the current article, we review the features of albumin, as well as its interaction with AuNPs, focusing on its biomedical applications.

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“…The folate receptor is overexpressed in many cancer cells, and folic acid-functionalized liposomes and nanoparticles are widely used for targeted drug delivery to tumors. 33,34 The surface of MLs prepared with the same lipid composition and $6 nm MNPs were PEGylated and functionalized with folic acid by treatment with a mixture of DSPE-PEG 2000 and DSPF-PEG 2000 -folate (95 : 5 molar ratio). Folate receptor-expressing HeLa cells were used as a model to check the cell isolation efficiency.…”

Section: Folate Receptor-targeted Isolation Of Cancer Cells Using Mlsmentioning

confidence: 99%

Magnetoliposomes with size controllable insertion of magnetic nanoparticles for efficient targeting of cancer cells

et al. 2019

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Hybrid folic acid-conjugated gold nanorods-loaded human serum albumin nanoparticles for simultaneous photothermal and chemotherapeutic therapy

Cited by 21 publications

References 54 publications

Combination of light-driven co-delivery of chemodrugs and plasmonic-induced heat for cancer therapeutics using hybrid protein nanocapsules

Combination of light-driven co-delivery of chemodrugs and plasmonic-induced heat for cancer therapeutics using hybrid protein nanocapsules

<p>Capping gold nanoparticles with albumin to improve their biomedical properties</p>

Magnetoliposomes with size controllable insertion of magnetic nanoparticles for efficient targeting of cancer cells

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