2018
DOI: 10.1016/j.msec.2018.06.002
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Hybrid folic acid-conjugated gold nanorods-loaded human serum albumin nanoparticles for simultaneous photothermal and chemotherapeutic therapy

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Cited by 21 publications
(12 citation statements)
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“…Free DTX was also incorporated to different extents within the protein NPs when corresponding as mentioned above, to provide the nanoplatform with dual chemotherapeutic activity (see Additional file 1 for further details on DTX loading, and resulting nanocarrier characterization). Finally, an 8-carbon side-chain hydrophobically-modified chitosan previously synthesized in the group [3338] was adsorbed onto the hybrid HSA NPs to provide the resulting platform with further colloidal stability and cationic electric surface charge. The hydrophobic side chains of the formed chitosan shell may favor larger cell affinities compared to nanocarriers, which only exploit ionic interactions for cell attachment [39].…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…Free DTX was also incorporated to different extents within the protein NPs when corresponding as mentioned above, to provide the nanoplatform with dual chemotherapeutic activity (see Additional file 1 for further details on DTX loading, and resulting nanocarrier characterization). Finally, an 8-carbon side-chain hydrophobically-modified chitosan previously synthesized in the group [3338] was adsorbed onto the hybrid HSA NPs to provide the resulting platform with further colloidal stability and cationic electric surface charge. The hydrophobic side chains of the formed chitosan shell may favor larger cell affinities compared to nanocarriers, which only exploit ionic interactions for cell attachment [39].…”
Section: Resultsmentioning
confidence: 99%
“…Human serum albumin nanocapsules were prepared by a conventional desolvation method with some modifications, as previously reported [33]. First, a HSA stock solution (20 mg/mL pH 5.5) was made: 5 mg of HSA were mixed with 500 µL of pure ethanol to prepare bare HSA NPs (or with 500 µL of PSS-coated (1·10 11 NP/mL), or PSS/DOXO-coated GNRs (1·10 11 NP/mL) as corresponding) at 830 rpm.…”
Section: Methodsmentioning
confidence: 99%
“…Biomedical applications involving AuNPs are mainly based on nanoparticles with spherical,22,39,44,111113 nanorod,12,68,107,114118 nanoprism5,119,120 and nanocluster geometry;6,121125 however, current synthetic methods allow for the development of nanoparticles with different morphologies. Morphological changes can also modulate the physicochemical properties of AuNPs, which in combination with SA may be improved and exploited for therapeutic applications.…”
Section: Biomedical Applications Of Albumin-aunpsmentioning
confidence: 99%
“…The folate receptor is overexpressed in many cancer cells, and folic acid-functionalized liposomes and nanoparticles are widely used for targeted drug delivery to tumors. 33,34 The surface of MLs prepared with the same lipid composition and $6 nm MNPs were PEGylated and functionalized with folic acid by treatment with a mixture of DSPE-PEG 2000 and DSPF-PEG 2000 -folate (95 : 5 molar ratio). Folate receptor-expressing HeLa cells were used as a model to check the cell isolation efficiency.…”
Section: Folate Receptor-targeted Isolation Of Cancer Cells Using Mlsmentioning
confidence: 99%