<p>Capping gold nanoparticles with albumin to improve their biomedical properties</p>

Abstract

Nanotechnology is an emerging field which has created great opportunities either through the creation of new materials or by improving the properties of existing ones. Nanoscale materials with a wide range of applications in areas ranging from engineering to biomedicine have been produced. Gold nanoparticles (AuNPs) have emerged as a therapeutic agent, and are useful for imaging, drug delivery, and photodynamic and photothermal therapy. AuNPs have the advantage of ease of functionalization with therapeutic agents through covalent and ionic binding. Combining AuNPs and other materials can result in nanoplatforms, which can be useful for biomedical applications. Biomaterials such as biomolecules, polymers and proteins can improve the therapeutic properties of nanoparticles, such as their biocompatibility, biodistribution, stability and half-life. Serum albumin is a versatile, non-toxic, stable, and biodegradable protein, in which structural domains and functional groups allow the binding and capping of inorganic nanoparticles. AuNPs coated with albumin have improved properties such as greater compatibility, bioavailability, longer circulation times, lower toxicity, and selective bioaccumulation. In the current article, we review the features of albumin, as well as its interaction with AuNPs, focusing on its biomedical applications.

Attaching DNA to Gold Nanoparticles With a Protein Corona

“…BSA is the most commonly used protein for surface blocking (An and Zhang, 2017;Chen et al, 2017;Nguyen et al, 2018), and it was also used for blocking gold surfaces (Dominguez-Medina et al, 2013;Tebbe et al, 2015;Bolaños et al, 2019). While most previous work focused on bulk gold surfaces, for AuNPs, the effect of BSA adsorption has yet to be systemically studied to gain fundamental information, such as the adsorption stability and kinetics, and the effect on colloidal stability.…”

<p>Ultra-Small Lysozyme-Protected Gold Nanoclusters as Nanomedicines Inducing Osteogenic Differentiation</p>

“…19 However, most of these AuNPs (5-100 nm) related medicines are still difficult to be cleaned from the body because of their large sizes. 20 The remaining gold is still a concern for safe medication. It is of great importance to further improve these gold related nanomedicines for the therapy of osteoporosis to decrease this concern.…”

Accelerated Osteogenic Differentiation of MC3T3-E1 Cells by Lactoferrin-Conjugated Nanodiamonds through Enhanced Anti-Oxidant and Anti-Inflammatory Effects

“…During the last 10 years, nanomaterials have been utilized in biomedical applications [22,23]. Among these, carbon-based nanomaterials such as carbon nanotubes, fullerenes, graphene and nanodiamond are major components of all living things [24].…”