The hybrid finite element method and statistical energy method was used to study the vibro-acoustic coupling characteristics of an engineering vehicle cab. The parameters of the statistical energy method, such as modal densities, damping loss factors and coupling loss factors of substructures, were acquired by numerical and analytical methods. The acoustic-structure coupling of the cab was established based on the modal densities of substructures. The vibration and noise excitations of the cab were measured by test and the sound pressure level response of the driver's ear was predicted. It was shown that the prediction results based on the hybrid method are in agreement with the experiments and the proposed method can be applied to predict the mid-frequency response of complex vibro-acoustic coupling systems with a moderate computational cost and accuracy.