Hybrid Dysgenesis in Drosophila Melanogaster: A Possible Explanation in Terms of Spatial Organization of Chromosomes

Ja, Sved

doi:10.1071/bi9760375

Cited by 82 publications

(39 citation statements)

References 25 publications

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“…Reactive and neutral strains thus seem to result from genetic changes which occur most readily in small isolates maintained in laboratory conditions . In connection with this, it may be noted that several authors (Rosenfeld et al, 1971;Sved, 1976;Kearsey et al, 1977;Kidwell et al, 1977) have reported cases of female sterility which seem to bear some similarity to our observations.…”

Section: Introductionsupporting

confidence: 61%

Non-mendelian female sterility in Drosophila melanogaster: Hereditary transmission of reactivity levels

Bucheton¹,

Picard²

1978

Heredity

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SUMMARYCrosses between various strains of Drosophila melanogaster may give rise to a female sterility of non-Mendelian determination. When two factors, of as yet unknown nature, are contributed by the gametes from which F, females originate, these flies may show a more or less strongly reduced fertility. The factor carried by "reactive" strains (R factor) varies considerably in its ability to reduce fertility. This characteristic was used in experiments to analyse the heredity of R. It appears to be under complex control involving both extrachromosomal and classical nuclear inheritance.

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Section: Introductionsupporting

confidence: 61%

Non-mendelian female sterility in Drosophila melanogaster: Hereditary transmission of reactivity levels

Bucheton¹,

Picard²

1978

Heredity

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“…Some authors have suggested that the configurations of chromosomes within the interphase nucleus are under specific genetic control (41,42). In a direct approach to these problems, we have been analyzing chromosome folding patterns with the aid of intradistance plots (27,36).…”

Section: Chromosomes Assume a Wide Variety Of Configurationsmentioning

confidence: 99%

Spatial organization of chromosomes in the salivary gland nuclei of Drosophila melanogaster.

Hochstrasser¹,

Mathog²,

Gruenbaum³

et al. 1986

The Journal of Cell Biology

251

221

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Abstract. Using a computer-based system for model building and analysis, three-dimensional models of 24Drosophila melanogaster salivary gland nuclei have been constructed from optically or physically sectioned glands, allowing several generalizations about chromosome folding and packaging in these nuclei. First and most surprising, the prominent coiling of the chromosomes is strongly chiral, with fight-handed gyres predominating. Second, high frequency appositions between certain loci and the nuclear envelope appear almost exclusively at positions of intercalary heterochromatin; in addition, the chromocenter is always apposed to the envelope. Third, chromosomes are invariably separated into mutually exclusive spatial domains while usually extending across the nucleus in a polarized (Rabl) orientation. Fourth, the arms of each autosome are almost always juxtaposed, but no other relative arm positions are strongly favored. Finally, despite these nonrandom structural features, each chromosome is found to fold into a wide variety of different configurations. In addition, a set of nuclei has been analyzed in which the normally aggregrated centromeric regions of the chromosomes are located far apart from one another. These nuclei have the same architectural motifs seen in normal nuclei. This implies that such characteristics as separate chromosome domains and specific chromosomenuclear envelope contacts are largely independent of the relative placement of the different chromosomes within the nucleus.E UKARYOTIC cells contain enormous lengths of DNA that must undergo considerable packing to fit inside the interphase nucleus. The packing is accomplished through multiple foldings of the DNA molecule within each chromosome and the folding of the chromosomes themselves inside the nucleus. This hierarchy of foldings is under several general constraints. First, the DNA must be available to regulatory factors and transcriptional machinery in such a way that readout of the genome can be precisely controlled. Second, the resident copies of DNA must be faithfully duplicated and repackaged with histones and other proteins; in dividing cells, the daughter helices must also be topologically resolved. Finally, nuclear division depends on a number of tightly orchestrated events: condensation of chromatin into compact chromosomes, dissolution of the nuclear envelope, movement of chromosomes to a central plate with subsequent splitting of daughter chromatids toward opposite poles, decondensation of daughter chromosomes, and reassembly of the nuclear envelope around them.Despite the interest in elucidating the means by which cells accommodate these constraints and package their genomes, only a meager sketch of higher order structures can currently be claimed. Beyond the level of the 10-nm nucleosomal fiber, little.consensus has been reached. This is particularly true of the highest level of chromosome organization, the threedimensional arrangement of chromosomes in the interphase nucleus. For reviews, see references 13 and 21.The giant ...

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“…The term "hybrid dysgenesis" has been proposed to refer collectively to this syndrome of abnormalities (Sved, 1976).…”

Section: Introductionmentioning

confidence: 99%

Hybrid dysgenesis in drosophila melanogaster: The frequency and distribution of male recombination events

Eggleston

1984

Heredity

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The frequency and distribution of male recombination events induced in dysgenic hybrids of Drosophila melanogaster has been investigated. Two wild-type inbred lines extracted from the "Texas" population were shown to differ substantially in the location of chromosome breakage points, thereby providing evidence that populations display heterogeneity of integration sites for the transposable elements responsible for dysgenic interactions. An attempt has been made to relate these data to current views on the molecular basis of hybrid dysgenesis.Evidence is provided which suggests that male recombination, SF female sterility and GD female sterility are induced by the same mobile genetic elements, indicating an identiy of the P-M and I-R interaction systems. The basis of the reported independence of these systems is discussed.

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Hybrid Dysgenesis in Drosophila Melanogaster: A Possible Explanation in Terms of Spatial Organization of Chromosomes

Cited by 82 publications

References 25 publications

Non-mendelian female sterility in Drosophila melanogaster: Hereditary transmission of reactivity levels

Non-mendelian female sterility in Drosophila melanogaster: Hereditary transmission of reactivity levels

Spatial organization of chromosomes in the salivary gland nuclei of Drosophila melanogaster.

Hybrid dysgenesis in drosophila melanogaster: The frequency and distribution of male recombination events

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