Hybrid diamond/ carbon fiber microelectrodes enable multimodal electrical/chemical neural interfacing

Hejazi, Maryam; Tong, Wei; Stacey, Alastair; Soto-Breceda, Artemio; Ibbotson, M.; Yunzab, Molis; Maturana, Matias I.; Almasi, Ali; Jung, Young Jun; Sun, Shi Hai; Meffin, Hamish; Fang, J.; Stamp, Melanie; Ganesan, Kumaravelu; Fox, Kate; Rifai, Aaqil; Nadarajah, Arunan; Falahatdoost, Samira; Prawer, S.; Apollo, Nicholas V.; Garrett, David J.

doi:10.1016/j.biomaterials.2019.119648

Cited by 44 publications

(49 citation statements)

References 60 publications

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“…[4,6b,23] In this study, the CIC measurements were conducted using 500 µs pulses, a commonly used duration in many other reports. [9,24] As CIC increases with pulse duration, the CIC of B-CNW coated fibers is smaller than that of PEDOT:PSS -co-MA coated CFs, but larger than that of The electrodes (orange lines) were placed at an angle of 15° with respect to the retinal surfaces. When the electrodes were placed parallel with the axon bundles (a,b), only nearby RGCs were stimulated.…”

Section: Discussionmentioning

confidence: 99%

“…B-CNW Deposition: Polyacrylonitrile-based CFs (Goodfellow) were first functionalized with nanodiamonds, as described previously. [9] Briefly, the CFs were first functionalized with nitrophenyl groups, and then aminophenyl groups via two-step electrochemistry. Following aminophenyl functionalization, they were covalently seeded with oxygen-terminated nanodiamond via 1-ethyl-3-{3-dimethylaminopropyl) carbodiimide hydrochloride chemistry.…”

Section: Methodsmentioning

confidence: 99%

“…Several coating materials have previously been used, including iridium oxide, [ 6b ] conductive polymers such as poly(3,4‐ethylenedioxythiophene)‐poly(styrenesulfonate) (PEDOT:PSS), [ 2e,f,6a ] and our recent report of nitrogen included ultrananocrystalline diamond (N‐UNCD). [ 9 ] All these coating materials improved the electrode charge injection capacity, however the stability of the coatings upon bending and under repetitive stimulation has rarely been demonstrated.…”

Section: Introductionmentioning

confidence: 99%

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High Fidelity Bidirectional Neural Interfacing with Carbon Fiber Microelectrodes Coated with Boron‐Doped Carbon Nanowalls: An Acute Study

Hejazi

Tong

Stacey

et al. 2020

Adv Funct Materials

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Implantable electrodes that can communicate with a small, selective group of neurons via both neural stimulation and recording are critical for the development of advanced neuroprosthetic devices. Microfiber electrodes with neuron-scale cross-sections have the potential to improve the spatial resolution for both stimulation and recording, while minimizing the chronic inflammation response after implantation. In this work, glass insulated microfiber electrodes are fabricated by coating carbon fibers with borondoped carbon nanowalls. The coating significantly improves the electrochemical properties of carbon fibers, leading to a charge injection capacity of 7.82 ± 0.35 mC cm −2 , while retaining good flexibility, stability and biocompatibility. When used for neural interfacing, the coated microelectrodes successfully elicit localized stimulation responses in explanted retina, and are also able to detect signals from single neurons, in vivo with a signal-to-noise ratio as high as 6.7 in an acute study. This is the first report of using carbon nanowall coated carbon fibers for neural interfacing.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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High Fidelity Bidirectional Neural Interfacing with Carbon Fiber Microelectrodes Coated with Boron‐Doped Carbon Nanowalls: An Acute Study

Hejazi

Tong

Stacey

et al. 2020

Adv Funct Materials

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“…When compared to traditionally used carbon‐fibre electrodes, diamond electrodes were found to be more physically robust and demonstrated capability for long implantations without deterioration (Bennet et al, 2016). Nitrogen‐included diamond electrodes were demonstrated in work by Garrett et al to be a suitable material with high charge injection capacity, therefore capable of becoming neural stimulation electrodes (Ahnood et al, 2017; Garrett et al, 2012) (Figure 4), later demonstrated in work from the same group (Hejazi et al, 2020). In work of a different area, Halpern et al used a BDD electrode to monitor a nerve involved in the feeding of freely behaving marine molluscs over a long period (28 days).…”

Section: Fabrication and Application Of Different Diamond Surfaces Fomentioning

confidence: 99%

“…All three areas for neural application are covered in work by Hejazi et al, where the multimodality of diamond electrodes is showcased. Here, developed hybrid electrodes of diamond and carbon fibre were demonstrated to measure single-neuron action potentials, deliver effective stimulation pulses and measure dopamine (Hejazi et al, 2020). Multiple electrodes were used in work by Ogata et al; a microsensing system containing a PCD grown BDD diamond electrode was used to monitor drug delivery within a cochlea and brain, in vivo and in real time, while a simultaneous recording of electrical activity occurred using a glass microelectrode, as seen in Figure 4 (Ogata et al, 2017).…”

Section: Chemical Vapour Deposition To Fabricate Diamond Thin Filmsmentioning

confidence: 99%

Diamond in medical devices and sensors: An overview of diamond surfaces

et al. 2020

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The human body is a sophisticated environment for research. There has been progress in developing advanced medical devices and sensors to contribute to recovery and therapy. However, as the field progresses new materials with specific properties are required to maximize recovery and therapy efficiency. Desired properties include materials that can contribute to cell regeneration and proliferation while preventing bacterial biofilm formation. Additionally, the variability in geometries of diseased parts requires improvement in processing to provide case and geometry-specific solutions (Raghavendra et al., 2015). Hence, there is a need for novel biomaterials that better match the native tissue. Their effectiveness and functionality are crucial to the long-term physical activity and health of patients. Carbon-based materials have attracted attention due to their unique characteristics, including mechanical, thermal and optical properties (Martel-Estrada, 2018), and they have been used in the

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Highly Flexible and Twistable Freestanding Single Crystalline Magnetite Film with Robust Magnetism

Zhong

et al. 2020

Adv Funct Materials

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Magnetic materials and devices that can be folded and twisted without sacrificing their functional properties are highly desirable for flexible electronic applications in wearable products and implantable systems. In this work, a high‐quality single crystalline freestanding Fe3O4 thin film with strong magnetism has been synthesized by pulsed laser deposition using a water‐dissolvable Sr3Al2O6 sacrificial layer, and the resulting freestanding film, with magnetism confirmed at multiple length scales, is highly flexible with a bending radius as small as 7.18 µm and twist angle as large as 122°, in sharp contrast with bulk magnetite that is quite brittle. When transferred to a polydimethylsiloxane support layer, the Fe3O4 film can be bent with large deformation without affecting its magnetization, demonstrating its robust magnetism. The work thus offers a viable solution for flexible magnetic materials that can be utilized in a range of applications.

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Hybrid diamond/ carbon fiber microelectrodes enable multimodal electrical/chemical neural interfacing

Cited by 44 publications

References 60 publications

High Fidelity Bidirectional Neural Interfacing with Carbon Fiber Microelectrodes Coated with Boron‐Doped Carbon Nanowalls: An Acute Study

High Fidelity Bidirectional Neural Interfacing with Carbon Fiber Microelectrodes Coated with Boron‐Doped Carbon Nanowalls: An Acute Study

Diamond in medical devices and sensors: An overview of diamond surfaces

Highly Flexible and Twistable Freestanding Single Crystalline Magnetite Film with Robust Magnetism

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