High Fidelity Bidirectional Neural Interfacing with Carbon Fiber Microelectrodes Coated with Boron‐Doped Carbon Nanowalls: An Acute Study

Hejazi, Maryam; Tong, Wei; Stacey, Alastair; Sun, Shi Hai; Yunzab, Molis; Almasi, Ali; Jung, Young Jun; Meffin, Hamish; Fox, Kate; Edalati, Khatereh; Nadarajah, Arunan; Prawer, S.; Ibbotson, M.; Garrett, David J.

doi:10.1002/adfm.202006101

Cited by 12 publications

(17 citation statements)

References 42 publications

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“…3D carbon nanostructures, such as carbon fibers (CFs) and carbon nanotubes (CNTs), can be utilized as a standalone electrode or as a surface coating to improve the surface area and electrochemical impedance (Kozai et al, 2012 ; Fattahi et al, 2014 ; Patel et al, 2016 , 2017 ; Fairfield, 2018 ). Standalone carbon fiber microelectrodes (CFMEs) are typically constructed by insulating carbon nanofibers with pulled glass pipettes (Hejazi et al, 2020 ) or PA (Guitchounts et al, 2013 ; Patel et al, 2015 ; Deku et al, 2018 ; Gillis et al, 2018 ; Massey et al, 2019 ) followed by opening the electrode tip with chemical etching, plasma removal, or laser cutting. Recently Patel et al assembled 16 CFMEs to form a multichannel CFME array, capable of chronic recording of single unite activity for one month (Patel et al, 2015 ).…”

Section: Electrode Materialsmentioning

confidence: 99%

A Review: Electrode and Packaging Materials for Neurophysiology Recording Implants

Yang

Gong

2021

Front. Bioeng. Biotechnol.

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To date, a wide variety of neural tissue implants have been developed for neurophysiology recording from living tissues. An ideal neural implant should minimize the damage to the tissue and perform reliably and accurately for long periods of time. Therefore, the materials utilized to fabricate the neural recording implants become a critical factor. The materials of these devices could be classified into two broad categories: electrode materials as well as packaging and substrate materials. In this review, inorganic (metals and semiconductors), organic (conducting polymers), and carbon-based (graphene and carbon nanostructures) electrode materials are reviewed individually in terms of various neural recording devices that are reported in recent years. Properties of these materials, including electrical properties, mechanical properties, stability, biodegradability/bioresorbability, biocompatibility, and optical properties, and their critical importance to neural recording quality and device capabilities, are discussed. For the packaging and substrate materials, different material properties are desired for the chronic implantation of devices in the complex environment of the body, such as biocompatibility and moisture and gas hermeticity. This review summarizes common solid and soft packaging materials used in a variety of neural interface electrode designs, as well as their packaging performances. Besides, several biopolymers typically applied over the electrode package to reinforce the mechanical rigidity of devices during insertion, or to reduce the immune response and inflammation at the device-tissue interfaces are highlighted. Finally, a benchmark analysis of the discussed materials and an outlook of the future research trends are concluded.

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Section: Electrode Materialsmentioning

confidence: 99%

A Review: Electrode and Packaging Materials for Neurophysiology Recording Implants

Yang

Gong

2021

Front. Bioeng. Biotechnol.

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“…Many carbon-based microfibers have been confirmed as biocompatible and biostable, both in vitro and in vivo (Smart et al, 2006;Chang et al, 2011;Kim et al, 2013;Guo et al, 2015;Wang et al, 2019;Hejazi et al, 2020b). Biocompatibility refers to biological "harmlessness, " or, alternatively, how well a living organism tolerates and survives the implant without triggering unacceptable reactions or changes (Gunter et al, 2019).…”

Section: Minimal Tissue Responsementioning

confidence: 99%

“…There are several methods for evaluating the stability of the stimulation electrodes. The first method is to monitor the electrode properties during and after continuous stimulation with biphasic pulses (Hejazi et al, 2020b). The properties that are compared before and after several million pulses include CIC values, electrode impedances and the electrode surface morphology.…”

Section: Neural Stimulationmentioning

confidence: 99%

“…The properties that are compared before and after several million pulses include CIC values, electrode impedances and the electrode surface morphology. Voltage cycling tests provide another method for studying the electrode stability, in which both CSC values and surface morphologies are compared after thousands (1,000-17,000) of repetitive CV cycles (Peixoto et al, 2009;Venkatraman et al, 2011;Hejazi et al, 2020b). Many carbon-based microfibers have been shown to exhibit good stability after repetitive stimulation (Bennet et al, 2016;Hejazi et al, 2020b).…”

Section: Neural Stimulationmentioning

confidence: 99%

“…The Melbourne group have demonstrated two types of carbon-based coatings to improve the performance of CF electrodes for neural interfacing, viz., nitrogen included ultrananocyrslline diamond (N-UNCD) (Hejazi et al, 2020a) and boron-doped carbon nanowalls (B-CNW) (Hejazi et al, 2020b). N-UNCD is biocompatible due to its chemical and biochemical inertness, and has previously been used as the electrode material for neural stimulation in a retinal prosthetic device for restoring vision (Garrett et al, 2012;Hadjinicolaou et al, 2012;Ganesan et al, 2014;Tong et al, 2016;Ahnood et al, 2017).…”

Section: Carbon Fibers (Cf)mentioning

confidence: 99%

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Advances in Carbon-Based Microfiber Electrodes for Neural Interfacing

et al. 2021

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Neural interfacing devices using penetrating microelectrode arrays have emerged as an important tool in both neuroscience research and medical applications. These implantable microelectrode arrays enable communication between man-made devices and the nervous system by detecting and/or evoking neuronal activities. Recent years have seen rapid development of electrodes fabricated using flexible, ultrathin carbon-based microfibers. Compared to electrodes fabricated using rigid materials and larger cross-sections, these microfiber electrodes have been shown to reduce foreign body responses after implantation, with improved signal-to-noise ratio for neural recording and enhanced resolution for neural stimulation. Here, we review recent progress of carbon-based microfiber electrodes in terms of material composition and fabrication technology. The remaining challenges and future directions for development of these arrays will also be discussed. Overall, these microfiber electrodes are expected to improve the longevity and reliability of neural interfacing devices.

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Organic Neuroelectronics: From Neural Interfaces to Neuroprosthetics

Lee

Seo

et al. 2022

Advanced Materials

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signals transmit various information from internal and external environments of organisms to each organ. Neurological diseases can impede transmission of neural signals and can cause severe symptoms. These diseases significantly reduce the quality of life, and can also be life-threatening. Neurological disease is a leading cause of disability-adjusted lifeyears (DALYs) which affected more than 276 million people globally in 2016. [1] In 2010 in the US, DALYs of spinal cord injuries were 445 911, which was higher than those of human immunodeficiency virus (HIV)/acquired immune deficiency syndrome (AIDS). [2] Drugs and neurosurgery are being developed to treat neurological diseases, but due to complex pathophysiology are not always effective. [3] Cell therapies repair the damaged tissues by introducing new cells, and gene therapies treat neurological disease by introducing genes into the body. These therapies enable fundamental treatment because they remove damaged cells and defective genes that are the causes of the diseases, but may cause severe or fatal side-effects such as immune responses. [4,5] Therefore, new methods for general treatment of neurological disease are being sought.Electric therapy is a promising method to diagnose disease by recording neural electronic signals and to treat disorders by using electrical signals to stimulate tissues. [6] The electrical stimulation has few side-effects, and is regarded as a possible and safe method to treat intractable neurological disorders. [7] For example, electrical stimulation has successfully recovered the lost functions from spinal cord injury. [8] However, despite these advantages, the development of neuroelectronics is still in its infancy; further research must be conducted to improve its efficacy and stability and to ensure that it does not limit daily life.Neuroelectronics can be divided into two main categories: neural interfaces that record or stimulate neural signals, and neuroprosthetics that replace damaged sensory and motor organs and neural signal pathway. Among the diverse forms of neuroprosthetics, this review focuses on bioelectronic devices that relay electrophysiological signals by bypassing damaged nerves. Conventionally, metal electrodes have been developed as a neural electrode for diagnosis and treatment due to their high electrical conductivity, and ease of processing in high density arrays. [9][10][11] For example, use of metal electrodes for electroencephalography (EEG) is a promising method to diagnose epilepsy. [12] Also, deep Requirements and recent advances in research on organic neuroelectronics are outlined herein. Neuroelectronics such as neural interfaces and neuroprosthetics provide a promising approach to diagnose and treat neurological diseases. However, the current neural interfaces are rigid and not biocompatible, so they induce an immune response and deterioration of neural signal transmission. Organic materials are promising candidates for neural interfaces, due to their mechanical softness, excellent electrochemical p...

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High Fidelity Bidirectional Neural Interfacing with Carbon Fiber Microelectrodes Coated with Boron‐Doped Carbon Nanowalls: An Acute Study

Cited by 12 publications

References 42 publications

A Review: Electrode and Packaging Materials for Neurophysiology Recording Implants

A Review: Electrode and Packaging Materials for Neurophysiology Recording Implants

Advances in Carbon-Based Microfiber Electrodes for Neural Interfacing

Organic Neuroelectronics: From Neural Interfaces to Neuroprosthetics

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