Hybrid Composite of Silver Nanoparticle–Porous Silicon Microparticles as an Image-Guided Localization Agent for Computed Tomography Scan of the Lungs

Lee, Eun Mi; Kim, Yejin; Yi, Kyung Sik; Cho, Janggeun; Kim, Jae-Hoon; An, Jong Min; Lee, Dahae; Kim, Sung Joon; An, Eunkyung; Hong, Yoo Jin; Jo, Hyejung; Lee, Seo Hyeon; Jung, Yuna; Choi, Chi Hoon; Kang, Jae Seung; Hur, Jin; Kim, Dokyoung

doi:10.1021/acsbiomaterials.0c00611

Cited by 10 publications

(4 citation statements)

References 42 publications

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“…At 8 and 24 h after injection, the nano silver-pSiMPs treatment group did not present activated lymphocytes or histological changes. 88 …”

Section: Promising Methods To Overcome Nano Silver-induced Cytotoxicitymentioning

confidence: 99%

Nano Silver-Induced Toxicity and Associated Mechanisms

Zhang¹,

Wang²,

Yalamarty³

et al. 2022

IJN

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Nano silver is one of the most widely used engineering nanomaterials with antimicrobial activity against bacteria, fungi, and viruses. However, the widespread application of nano silver preparations in daily life raises concerns about public health. Although several review articles have described the toxicity of nano silver to specific major organs, an updated comprehensive review that clearly and systematically outlines the harmful effects of nano silver is lacking. This review begins with the routes of exposure to nano silver and its distribution in vivo. The toxic reactions are then discussed on three levels, from the organ to the cellular and subcellular levels. This review also provides new insights on adjusting the toxicity of nano silver by changing their size and surface functionalization and their combination with other materials to form a composite formulation. Finally, future development, challenges, and research directions are discussed.

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“…At 8 and 24 h after injection, the nano silver-pSiMPs treatment group did not present activated lymphocytes or histological changes. 88 …”

Section: Promising Methods To Overcome Nano Silver-induced Cytotoxicitymentioning

confidence: 99%

Nano Silver-Induced Toxicity and Associated Mechanisms

Zhang¹,

Wang²,

Yalamarty³

et al. 2022

IJN

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“…The strong CT signal intensity of Au, Ag or iodine hybrid materials is mainly generated from the high X‐ray absorption coefficients of gold, silver and iodine (X‐ray absorption coefficient at 100 keV, Au: 5, 16 cm 2 /g; I: 1.94 cm 2 /g; Ag: 1.47 cm 2 /g). Additionally, gold and silver atoms can produce strong X‐ray attenuation due to their high density (19.32 g/cm 3 and 10.49 g/cm 3 , respectively), which makes the Fe 3 O 4 @Ag@PAA HNPs may in the future become contrast agent ideal for computed tomography (CT) instead of conventional iodine‐based contrast agents [60,61] …”

Section: Resultsmentioning

confidence: 99%

“…Additionally, gold and silver atoms can produce strong X-ray attenuation due to their high density (19.32 g/cm 3 and 10.49 g/ cm 3 , respectively), which makes the Fe 3 O 4 @Ag@PAA HNPs may in the future become contrast agent ideal for computed tomography (CT) instead of conventional iodine-based contrast agents. [60,61] Nextly, the potential to use Fe 3 O 4 @Ag nanoparticles as contrast agent in CT imaging was evaluated by scanning the same hybrid nanoparticle samples in the previous MRI experiment in the 128-Somatom Perspective CT scanner (Siemens), Germany). In there, the concentrations of both silver and iron samples were checked using ICP-MS.…”

Section: T 2 Mri Relaxivity and X-ray Attenuation Propertymentioning

confidence: 99%

Multimodal Imaging Contrast Property of Nano Hybrid Fe₃O₄@Ag Fabricated by Seed‐Growth for Medicinal Diagnosis

Nguyen

et al. 2022

ChemistrySelect

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Multimodal imaging, which integrates different imaging modalities, is emerging as a promising strategy to improve both preclinical and subclinical imaging. Computed tomography (CT) and magnetic resonance imaging (MRI) are among the imaging techniques widely used in clinical practice. These imaging modalities are used to diagnose and screen disease, each providing additional and different information about the patient and pathosis. In this research, we present the development of a model that combines a hybrid nanostructure, consisting of an iron oxide core and a silver‐shell nanoparticle for dual MRI/CT imaging. Fe3O4@Ag HNPs with core‐shell structure were fabricated by reducing Ag+ on the surface of Fe3O4 (NPs) nanoparticles by seed‐growth route in the thermal decomposition method. TEM images show that the synthesized nanoparticles have a uniform spherical shape and size, with an average diameter of 15.6 nm. The hybrid nanoparticles after functionalizing the surface with polyacrylic acid (PAA) became hydrophilic and dispersed well in water. The fluid of Fe3O4@Ag@PAA HNPs has high stability in water media with NaCl salt concentrations above 200 mM and a wide pH range from 4 to 11. The fluid Fe3O4@Ag@PAA has selective cytotoxicity with IC50 value 8.42 ug/ml for Hep‐G2 cell lines, and 40.3 ug/ml for normal Vero cell lines. The results of in‐vitro MRI/CT imaging showed that the value of transverse relaxation rate r2 was 138.6 mM−1s−1 and had good X‐ray attenuation ability. With these outstanding properties, the core‐shell structured nano hybrid fluid presented in this research has the potential as a candidate for multimodal bioimaging techniques in practical applications.

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“… [ 88 , 89 ] Hybrid and composite NPs Combines multiple materials or incorporates functional components to produce hybrid and composite NPs, offering versatility, synergistic effects, enhanced stability, and multifunctionality, with applications in catalysis, sensing, and energy storage. [ 90 ] …”

Section: Emerging Development and Novel Strategies For The Synthesis ...mentioning

confidence: 99%

Recent Advancements and Unexplored Biomedical Applications of Green Synthesized Ag and Au Nanoparticles: A Review

Ahmad,

Ali

et al. 2024

IJN

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Green synthesis of silver (Ag) and gold (Au) nanoparticles (NPs) has acquired huge popularity owing to their potential applications in various fields. A large number of research articles exist in the literature describing the green synthesis of Ag and Au NPs for biomedical applications. However, these findings are scattered, making it time-consuming for researchers to locate promising advancements in Ag and Au NPs synthesis and their unexplored biomedical applications. Unlike other review articles, this systematic study not only highlights recent advancements in the green synthesis of Ag and Au NPs but also explores their potential unexplored biomedical applications. The article discusses the various synthesis approaches for the green synthesis of Ag and Au NPs highlighting the emerging developments and novel strategies. Then, the article reviews the important biomedical applications of green synthesized Ag and Au NPs by critically evaluating the expected advantages. To expose future research direction in the field, the article describes the unexplored biomedical applications of the NPs. Finally, the articles discuss the challenges and limitations in the green synthesis of Ag and Au NPs and their biomedical applications. This article will serve as a valuable reference for researchers, working on green synthesis of Ag and Au NPs for biomedical applications.

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Hybrid Composite of Silver Nanoparticle–Porous Silicon Microparticles as an Image-Guided Localization Agent for Computed Tomography Scan of the Lungs

Cited by 10 publications

References 42 publications

Nano Silver-Induced Toxicity and Associated Mechanisms

Nano Silver-Induced Toxicity and Associated Mechanisms

Multimodal Imaging Contrast Property of Nano Hybrid Fe₃O₄@Ag Fabricated by Seed‐Growth for Medicinal Diagnosis

Recent Advancements and Unexplored Biomedical Applications of Green Synthesized Ag and Au Nanoparticles: A Review

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Hybrid Composite of Silver Nanoparticle–Porous Silicon Microparticles as an Image-Guided Localization Agent for Computed Tomography Scan of the Lungs

Cited by 10 publications

References 42 publications

Nano Silver-Induced Toxicity and Associated Mechanisms

Nano Silver-Induced Toxicity and Associated Mechanisms

Multimodal Imaging Contrast Property of Nano Hybrid Fe3O4@Ag Fabricated by Seed‐Growth for Medicinal Diagnosis

Recent Advancements and Unexplored Biomedical Applications of Green Synthesized Ag and Au Nanoparticles: A Review

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Multimodal Imaging Contrast Property of Nano Hybrid Fe₃O₄@Ag Fabricated by Seed‐Growth for Medicinal Diagnosis