Magnetic resonance imaging (MRI) has emerged as one of the most promising techniques, which employs nanoscience and imaging technology, for early diagnosis of the cancers. In this work, magnetic nanoparticles of Fe 3 O 4 @ poly(acrylic) acid (PAA) were synthesized using a low cost thermal decomposition method from iron ions precursor and utilized as a signal agent for MRI imaging. The Fe 3 O 4 magnetic nanoparticles obtained from FeCl 2 .4H 2 O precursor at the reaction temperature of 315°C in 1-octadcene solvent are of spherical shape with average diameter of 8.4 nm and high saturation magnetization (M s) of 60.05 emu/g. After phase transferred with PAA, the magnetic Fe 3 O 4 @PAA fluid is highly stable in a wide range of pHs solution (5-9) and wide range of NaCl concentrations (50-300 mM) with zeta potential of À 35.7 mV. The prepared Fe 3 O 4 @PAA fluid showed noncytotoxicity to the Hep-G2, MCF-7, RD cancer cell line and Vero healthy cell line. MRI in-vitro results showed that transverse relaxation rate r 2 was around 158.4 mM À 1 s À 1 and the signal intensity was not affected by the pHs solution and NaCl concentrations. In-vivo test on rabbit revealed the clear observation of rabbit's body parts after injection of the Fe 3 O 4 @PAA magnetic fluid with retention time of 90 minutes in the body.

Un-doped and Ni-doped FeS 2 nanoparticles (NPs) with a doping concentration of 4.0 at.% have been synthesized by a solvothermal method. The obtained materials have been characterized by means of XRD, SEM, BET, Raman and UV-VIS spectroscopy. The photocatalytic activity has been evaluated based on degrading methylene blue with thin films of the NPs under UV-VIS light irradiation. An important observation was that the activity increases in the sequence FeS 2 NPs fi Ni-doped FeS 2 NPs fi composite of FeS 2 NPs/rGO. The enhanced energy gap and enlarged surface area, achieved by the Nidoping and adding rGO were considered to be the main reason for the improved photocatalytic activity. Additionally, the mechanism of degradation has been studied using several scavengers. The photo-generated ÁOH and ÁO À 2 have shown to be dominant radicals in the visible light MB degradation. The presented data strongly suggest that the composite of FeS 2 NPs/rGO may be an efficient heterogeneous photo-catalyst for the degradation of the organic contaminant and water treatment. The proposed film forms of materials are promising for convenient reuse after a low-cost cleaning.

Multimodal imaging, which integrates different imaging modalities, is emerging as a promising strategy to improve both preclinical and subclinical imaging. Computed tomography (CT) and magnetic resonance imaging (MRI) are among the imaging techniques widely used in clinical practice. These imaging modalities are used to diagnose and screen disease, each providing additional and different information about the patient and pathosis. In this research, we present the development of a model that combines a hybrid nanostructure, consisting of an iron oxide core and a silver‐shell nanoparticle for dual MRI/CT imaging. Fe3O4@Ag HNPs with core‐shell structure were fabricated by reducing Ag+ on the surface of Fe3O4 (NPs) nanoparticles by seed‐growth route in the thermal decomposition method. TEM images show that the synthesized nanoparticles have a uniform spherical shape and size, with an average diameter of 15.6 nm. The hybrid nanoparticles after functionalizing the surface with polyacrylic acid (PAA) became hydrophilic and dispersed well in water. The fluid of Fe3O4@Ag@PAA HNPs has high stability in water media with NaCl salt concentrations above 200 mM and a wide pH range from 4 to 11. The fluid Fe3O4@Ag@PAA has selective cytotoxicity with IC50 value 8.42 ug/ml for Hep‐G2 cell lines, and 40.3 ug/ml for normal Vero cell lines. The results of in‐vitro MRI/CT imaging showed that the value of transverse relaxation rate r2 was 138.6 mM−1s−1 and had good X‐ray attenuation ability. With these outstanding properties, the core‐shell structured nano hybrid fluid presented in this research has the potential as a candidate for multimodal bioimaging techniques in practical applications.

Development of novel drugs or drug delivery systems has attracted much attention of researchers. In this study, we aimed to prepare 2 new Pt(II) complexes with thiosemicarbazone and their nanoformulations for cancer treatment application. Pt(II)-camphor thiosemicarbazone/ P1 and Pt(II)-camphor 4-phenyl thiosemicarbazone/P2) were successfully prepared and structurally confirmed by MS, IR, 1H-NMR, UV-vis spectroscopies and thermal analysis. From the complexes, 2 PLGA-based nanoformulations (nP1 and nP2) were synthesised with the average size of 50 nm by emulsification/evaporation method and investigated for their toxicity against Hep-G2, LU-1 and RD cancer cell lines. The results show that the Pt(II) complexes and their nanoformulations were potential for chemotherapy.

In this paper, copper (II) citrate Cu3(C6H5O7)2 was successfully synthesised in an aqueous solution. The factors for the synthesis process such as temperature and molar ratio of the reactants were investigated. The structural, properties and composition characteristics of the elements were investigated and evaluated by X-ray diffraction pattern (XRD), Fourier-transform infrared spectroscopy (FTIR), energy-dispersive X-ray spectroscopy (EDX), and UV-Vis spectroscopy. The yield of the copper (II) citrate in the reaction was 82.46% at the molar ratio of the CuSO4/C6H5Na3O7 of 1.5/1 at 70oC. The in vitro results showed that copper (II) citrate at a concentration of 1,000 ppm inhibits the mycelial growth of Sclerotium rolfsii and Fusarium oxysporumwith control values ranging from 19 to 53% after 2 days of incubation. Besides, it strongly suppressed the plant bacterial pathogens Xanthomonas axonopodis (bacterial strain causing citrus canker), Ralstonia solanacearum(bacterial wilt of tomato), and Clavibacter michiganensis subsp. michiganensis (cause of bacterial wilt and canker of tomato). These results suggested that copper (II) citrate can be used as a promising fungicide/bactericide to control fungal and bacterial diseases on citrus and tomato plants.