Hybrid Bionic Nerve Interface for Application in Bionic Limbs

Abstract

Intuitive and perceptual neuroprosthetic systems require a high degree of neural control and a variety of sensory feedback, but reliable neural interfaces for long‐term use that maintain their functionality are limited. Here, a novel hybrid bionic interface is presented, fabricated by integrating a biological interface (regenerative peripheral nerve interface (RPNI)) and a peripheral neural interface to enhance the neural interface performance between a nerve and bionic limbs. This interface utilizes a shape memory polymer buckle that can be easily implanted on a severed nerve and make contact with both the nerve and the muscle graft after RPNI formation. It is demonstrated that this interface can simultaneously record different signal information via the RPNI and the nerve, as well as stimulate them separately, inducing different responses. Furthermore, it is shown that this interface can record naturally evoked signals from a walking rabbit and use them to control a robotic leg. The long‐term functionality and biocompatibility of this interface in rabbits are evaluated for up to 29 weeks, confirming its promising potential for enhancing prosthetic control.

Stretchable, Self-Rolled, Microfluidic Electronics Enable Conformable Neural Interfaces of Brain and Vagus Neuromodulation

“…For example, vagus nerve stimulation treats heart failure and depression . However, the geometrical and mechanical mismatch at cuff electrode–nerve interfaces and fibrous nerves is still a formidable challenge . Due to the high stretchability and good deformability of MEA, we further develop self-rolled cuff electrodes for recording and stimulating peripheral nerves.…”

“…29 However, the geometrical and mechanical mismatch at cuff electrode−nerve interfaces and fibrous nerves is still a formidable challenge. 30 Due to the high stretchability and good deformability of MEA, we further develop self-rolled cuff electrodes for recording and stimulating peripheral nerves. Inspired by the self-rolling plants, we integrated the stressinduced rolling technique with the microfluidic electrodes to fabricate self-rolled cuff electrodes, which can self-roll onto the nerve and form flexible interfaces with minimal constraint (Figure 4a).…”