Hybrid Ag nanoparticles/polyoxometalate-polydopamine nano-flowers loaded chitosan/gelatin hydrogel scaffolds with synergistic photothermal/chemodynamic/Ag+ anti-bacterial action for accelerated wound healing

A bioinspired polydopamine–FeS nanocomposite with high antimicrobial efficiency via NIR-mediated Fenton reaction

“…4(a), which revealed that these products possessed a wide range of light absorption, possibly due to the conjugated system and the electron donor–acceptor structures in PDA. 39 Compared with bare PDA, there was a decrease in visible light absorption, whereas an increased absorption in the NIR region for PDA–Fe( ii ) and PDA@FeS, indicating that the coordination of Fe 2+ with PDA had an obvious influence on the absorption behavior, and one possible reason was that the π–π stacking interaction of PDA was destroyed by metal ion doping to some extent. Meanwhile, the light absorption profile of the PDA@FeS NPs was comparable to that of the PDA–Fe( ii ) complex and showed an obvious enhancement in the whole spectrum, which was partially caused by the strong absorbance in ferrous sulfide.…”

Supramolecular Nanozyme System Based on Polydopamine and Polyoxometalate for Photothermal-Enhanced Multienzyme Cascade Catalytic Tumor Therapy

“…First, the utilization of 3,3′,5,5′tetramethylbenzidine (TMB) as the colorimetric probe was suggested to measure the POD catalytic activity of PCP nanozymes. 42 In the acidic condition, PCP nanozymes were revealed to catalyze the production of • OH from a H 2 O 2 solution, leading to the oxidation of TMB and the formation of blue oxTMB, as proved by the characteristic peak at 652 nm in Figure 2b, further supported by the accompanying photograph (Figure 2b, inset). The absence of PCP nanozymes in control systems prevented the observation of such a peak, demonstrating the beneficial POD-like activity of PCP nanozymes.…”

Constructing a self-healing injectable SABA/Borax/PDA@AgNPs hydrogel for synergistic low-temperature photothermal antibacterial therapy

“…41 Moreover, the NIR irradiated group exhibited a higher Ag + release rate, and we assumed that this phenomenon was attributed to the heating effect of PDA. 42 It has been reported that PTT induced heat could greatly improve the permeability of bacterial cell membrane, thus accelerating the cellular permeation of chemical drugs. 43 Since Ag + and bacterial membrane are positively charged and negatively charged, respectively, we envision that PTT induced heat could boost bacterial cell uptake of Ag + , hence improving the sterilizing efficiency.…”