Hyaluronic acid scaffold for skin defects in congenital syndactyly release surgery: a novel technique based on the regenerative model

Abstract

Syndactyly release may require skin grafting to fill the skin defects, which might lead to complications or poor cosmetic outcomes. A simple graftless technique for syndactyly release with a hyaluronic acid (HA) scaffold used to cover the bare areas is described. Between 2008 and 2011, release of 26 webs in 23 patients was performed. All skin defects were covered with Hyalomatrix(®) PA. One patient was excluded due to early post-operative infection that required HA scaffold removal before its integration. Web creep, secondary deformities, scar quality, and patient and parental satisfaction were assessed. Mean follow-up of the group of 22 patients was 24 months. There were no secondary deformities and minimal degree of web creep. All patients had close to normal pigmentation and good pliability at the sites of scaffold application. The results confirm the use of a HA scaffold as a promising alternative to skin grafting in syndactyly release surgery.

Glycosaminoglycan and Proteoglycan Biotherapeutics in Articular Cartilage Protection and Repair Strategies: Novel Approaches to Visco‐supplementation in Orthobiologics

“…Mechanical damage to articular cartilage modulates lubricin biosynthesis. [116] HA has also been used as a nanoparticle delivery vehicle for drugs, RNA, DNA, and growth factors. [98] In mice lacking PRG4 a loss of articular cartilage structure, stiffness, and boundary lubrication severely depressed the articulatory properties of murine knee joints.…”

<p>Subjective Evaluation of the Results of Injectable Hyaluronic Acid Fillers for the Face</p>

“…A high level of satisfaction with the appearance of the facial skin after tear trough and temporal fossa augmentation was noted by Tung et al, and Berguiga et al 32,33 Jegasothy et al, 34 also reported beneficial effects (wrinkle depth reduction, improved skin hydration, firmness and elasticity) of low molecular nano-hyaluronic acid injections. Positive changes in the appearance of the facial skin after HA treatment (improved firmness and pigmentation) were observed by Landi et al 35 Trong et al 36 also documented improved skin elasticity and wrinkle depth reduction, while Baspeyras et al, 37 observed significant improvement in skin hydration, firmness and viscoelasticity after HA microinjection treatment. A statistically significantly improved radiance, pigmentation and hydration were observed by Sparavigna et al, 38 in the process of treating skin with symptoms of ageing and photoaging.…”

Therapeutic strategies for skin regeneration based on biomedical substitutes

“…In addition, Hyalograft 3D™ is composed by seeding autologous fibroblasts cultured over a 3D hyaluronic acid‐derived scaffold, named Hyalomatrix ® . Hyalomatrix ® consists of a bilayer composed by an outer silicone membrane that acts as a temporary epidermal barrier, and an internal hyaluronan scaffold . The TISSUEtech Autograft System™ represents a good attempt to biomimic the histology of the human skin and has also shown to be well tolerated whilst being able to heal diabetic ulcers and pressure wounds in 1 year or less …”

“…Hyalomatrix â consists of a bilayer composed by an outer silicone membrane that acts as a temporary epidermal barrier, and an internal hyaluronan scaffold. [34][35][36] The TISSUEtech Autograft System TM represents a good attempt to biomimic the histology of the human skin and has also shown to be well tolerated whilst being able to heal diabetic ulcers and pressure wounds in 1 year or less. 33 Nowadays other skin substitutes made of synthetic polymers, such as PLGA, polycaprolactone, or polypyrrole, are being investigated to generate membranes as platforms to seed fibroblasts.…”