Hyaluronic acid: Ray of hope for esthetically challenging black triangles: A case series

Patil, Sayali Chandrakant; Chandulal, Dhalkari; Indurkar, Maya

doi:10.4103/ccd.ccd_42_19

Cited by 8 publications

(8 citation statements)

References 18 publications

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“…Recently, the use of hyaluronic acid in mucogingival surgery has gained popularity as a valuable therapeutic tool for improving the health and aesthetics of the soft tissues in the oral cavity. 86 Progressively, surgical grade HA has been tested in soft tissue coverage procedures to improve the obtained clinical results in terms of root coverage, connective tissue thickening, and even periodontal attachment regeneration. 87 In periodontology, hyaluronic acid appears to be a promising tool in these interventions due to its unique properties such as hydrophilic and volumizing properties.…”

Section: Discussionmentioning

confidence: 99%

Hyaluronic acid in Dentoalveolar regeneration: Biological rationale and clinical applications

Mansour,

Acharya,

Alliot

et al. 2024

Journal of Oral Biology and Craniofacial Research

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Section: Discussionmentioning

confidence: 99%

Hyaluronic acid in Dentoalveolar regeneration: Biological rationale and clinical applications

Mansour,

Acharya,

Alliot

et al. 2024

Journal of Oral Biology and Craniofacial Research

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“…The use of HA in periodontology for the closure of black interdental triangles with small gel infiltrations, directly into the gum, was definitely a great impact [ 70 ]. This molecule is used based on its chemical characteristics, such as hygroscopicity, viscoelastic and filling properties of space, bacteriostatic effect, anti-edema, antioxidant, biocompatible and non-immunogenic.…”

Section: Discussionmentioning

confidence: 99%

Surface Treatment of the Dental Implant with Hyaluronic Acid: An Overview of Recent Data

Cervino

Meto

Fiorillo

et al. 2021

IJERPH

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Recently, interest has grown by focusing on the evaluation of a molecule already produced in the human body such as hyaluronic acid (HA), as an application to the surface of the titanium implant. Its osteo-conductive characteristics and positive interaction with the progenitor cells responsible for bone formation, consequently, make it responsible for secondary stability. The aim of this work was to analyze the various surface treatments in titanium implants, demonstrating that the topography and surface chemistry of biomaterials can correlate with the host response; also focusing on the addition of HA to the implant surface and assessing the biological implications during early stages of recovery. Used as a coating, HA acts on the migration, adhesion, proliferation and differentiation of cell precursors on titanium implants by improving the connection between implant and bone. Furthermore, the improvement of the bioactivity of the implant surfaces through HA could therefore facilitate the positioning of the dental prosthesis precisely in the early loading phase, thus satisfying the patients’ requests. It is important to note that all the findings should be supported by further experimental studies in animals as well as humans to evaluate and confirm the use of HA in any field of dentistry.

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“…Of these 24 studies included, 15 were prospective clinical studies [39,40,[48][49][50][51][52][53][54][55][56][57][58][59][60], and nine were randomised clinical trials [61][62][63][64][65][66][67][68][69]. Table 3 summarises the characteristics of the included studies.…”

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

“…Most studies investigated the effect of hyaluronic acid injection in treatment of lost interdental papilla prospectively over time [39,40,[48][49][50][51][52][53][54][55][56][57][58][59][60]62]. One study compared hyaluronic acid injection with negative control [64], three studies considered comparison with placebo control (saline injection) [61,65,67], while four studies compared hyaluronic acid injection to different materials, these include, plasma rich growth factors (PRGF) [63], injectable platelet rich fibrin (iPRF) [68], calcium hydroxyapatite filler (Radiesse) [69], and chitosan [66].…”

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

“…The Newcastle Ottawa quality assessment tool revealed generally good quality among the included prospective cohort studies [40,48,[49][50][51][52][53][54][56][57][58][59][60] except for two with poor quality according to the scale [39,55]. Detailed information regarding the three domains is presented in Table 6.…”

Section: Quality Assessment and Risk Of Bias In The Included Studiesmentioning

confidence: 99%

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The use of hyaluronic acid injection for treatment of black triangle and reconstruction of lost interdental papilla in anterior teeth: a systematic review

Alsharif,

Aljahdali

2024

AOS

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Objective: Non-surgical therapeutics to reconstruct lost interdental papilla are evolving; these include hyaluronic acid injection. The aim of this systematic review is to evaluate the efficacy, safety, and long-term outcomes of hyaluronic acid injection in the treatment of black triangles and reconstruction of lost interdental papilla in anterior teeth. Materials and Methods: The protocol was registered in PROSPERO (CRD42023446875) and in accordance with the Cochrane Handbook of Systematic Reviews of Interventions and the Preferred Reporting Items for Systematic Reviews and Meta-Analysis ‘PRISMA’. The search involved four databases, PubMed/MEDLINE, The Cochrane Library, Google Scholar, and ProQuest for ‘’grey literature’ with additional manual search for studies published up to May 2024. Human clinical studies of a prospective nature (randomised clinical trials and prospective cohort studies) were included. Exclusion criteria were case reports, case series, review articles, letter to editor, personal opinion, and animal studies. Furthermore, studies which utilised hyaluronic acid injection in conjunction with other therapeutic material, tissue graft, or any surgical procedure were also excluded. The data were extracted independently by the two authors and incorporated after consensus. The risk of bias was assessed using the RoB2: the revised Cochrane risk of bias tool for randomised clinical trials and the Newcastle Ottawa scale for prospective cohort studies. Results: 24 studies, 15 prospective clinical studies and nine randomised clinical trials, were included with a total of 898 interdental papillae injected with hyaluronic acid. The studies showed promising outcomes in the reconstruction of lost interdental papilla with minimal adverse reactions. Risk of bias assessment among prospective clinical studies revealed 13 good quality studies with only two poor studies while the randomised clinical trials consisted of three with low, one with some concern, and five studies with high risk of bias. However, due to the high heterogeneity, a meta-analysis was not feasible. Conclusion: Hyaluronic acid injection is an effective minimally invasive approach in treating black triangles and reconstructing lost interdental papilla in the anterior teeth. Further long-term well-designed randomised clinical trials employing standardised procedures are essential to validate this treatment and provide better quality of evidence.

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Hyaluronic acid: Ray of hope for esthetically challenging black triangles: A case series

Cited by 8 publications

References 18 publications

Hyaluronic acid in Dentoalveolar regeneration: Biological rationale and clinical applications

Hyaluronic acid in Dentoalveolar regeneration: Biological rationale and clinical applications

Surface Treatment of the Dental Implant with Hyaluronic Acid: An Overview of Recent Data

The use of hyaluronic acid injection for treatment of black triangle and reconstruction of lost interdental papilla in anterior teeth: a systematic review

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