Hyaluronic Acid

Selyanin, Mikhail A.; Boykov, Petr Ya.; Khabarov, Vladimir N.; Polyak, F. D.

doi:10.1002/9781118695920

Cited by 45 publications

(41 citation statements)

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“…Hyaluronic acid is a linear heteropolysaccharide (glucosaminoglycan, mucopolysaccharide) with high molecular weight formed by regularly repeating residues of N-acetyl-D-glucosamine and D-glucuronic acid [ 1 , 29 ]. In a hyaluronic acid molecule, the D-glucuronic acid is associated with amino-sugar by β-(1 → 3)-glycosidic linking, and amino-sugar is connected with the D-glucuronic acid by a β-(1 → 4)-glycoside tieup [ 17 ]. Obviously, that structure of the monomeric unit (named as the primary structure) is not dependent on the molecular weight of hyaluronic acid.…”

Section: Aqueous Hyaluronic Acid Solutions and Their Propertiesmentioning

confidence: 99%

“…The existence of polar and apolar segments in the polymer structure affords hyaluronic acid the capability to chemically interact with various chemical agents [ 17 ], for instance, with metachromatic dyes, which find application in clinical examinations [ 30 ], and chitosan, which makes it possible to obtain a new class of materials based on polyelectrolyte complexes [ 31 , 32 ].…”

Section: Aqueous Hyaluronic Acid Solutions and Their Propertiesmentioning

confidence: 99%

“…Therefore, bacterially derived hyaluronic acid purchased from Sigma and Genzyme includes only 1.0–1.6 μg protein and approximately 0.02 EU endotoxin per 1 mg hyaluronic acid [ 16 ]. Nevertheless, the level of immunogenic effect of protein residuals in bacterial hyaluronic acid could be greater than in animal hyaluronic acid despite the low summary protein content [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

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Hyaluronic Acid: The Influence of Molecular Weight on Structural, Physical, Physico-Chemical, and Degradable Properties of Biopolymer

et al. 2020

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Hyaluronic acid, as a natural linear polysaccharide, has attracted researchers’ attention from its initial detection and isolation from tissues in 1934 until the present day. Due to biocompatibility and a high biodegradation of hyaluronic acid, it finds wide application in bioengineering and biomedicine: from biorevitalizing skin cosmetics and endoprostheses of joint fluid to polymeric scaffolds and wound dressings. However, the main properties of aqueous polysaccharide solutions with different molecular weights are different. Moreover, the therapeutic effect of hyaluronic acid-based preparations directly depends on the molecular weight of the biopolymer. The present review collects the information about relations between the molecular weight of hyaluronic acid and its original properties. Particular emphasis is placed on the structural, physical and physico-chemical properties of hyaluronic acid in water solutions, as well as their degradability.

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Section: Aqueous Hyaluronic Acid Solutions and Their Propertiesmentioning

confidence: 99%

Section: Aqueous Hyaluronic Acid Solutions and Their Propertiesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Hyaluronic Acid: The Influence of Molecular Weight on Structural, Physical, Physico-Chemical, and Degradable Properties of Biopolymer

et al. 2020

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“…Examples include hyaluronic acid, first extracted from rooster combs and now used in cosmetic and biomedical products. 181,182 Heparin, which is used as anticoagulant, was first isolated from liver tissues while searching for anticoagulant factors in animal tissues. 183 Alginates, extracted from algae, have large scale applications as food texturing agents, 184 drug encapsulation material, 185 and in other niche biomedical applications.…”

Section: Challenges and Opportunitiesmentioning

confidence: 99%

Mucins as multifunctional building blocks of biomaterials

2018

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Mucins are large glycoproteins that are ubiquitous in the animal kingdom. Mucins coat the surfaces of many cell types and can be secreted to form mucus gels that assume important physiological roles in many animals. Our growing understanding of the structure and function of mucin molecules and their functionalities has sparked interest in investigating the use of mucins as building blocks for innovative functional biomaterials. These pioneering studies have explored how new biomaterials can benefit from the barrier properties, hydration and lubrication properties, unique chemical diversity, and bioactivities of mucins. Owing to their multifunctionality, mucins have been used in a wide variety of applications, including as antifouling coatings, as selective filters, and artificial tears and saliva, as basis for cosmetics, as drug delivery materials, and as natural detergents. In this review, we summarize the current knowledge regarding key mucin properties and survey how they have been put to use. We offer a vision for how mucins could be used in the near future and what challenges await the field before biomaterials made of mucins and mucin-mimics can be translated into commercial products.

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“…Interestingly, organic or mineral acids are utilized to improve the hyaluronic acid solutions’ conductivity, which allows for obtaining nanofibers [ 11 , 20 , 26 ]. However, even a small amount of acid leads to depolymerization of the hyaluronic acid [ 28 ].…”

Section: Introductionmentioning

confidence: 99%

Curcumin/Usnic Acid-Loaded Electrospun Nanofibers Based on Hyaluronic Acid

et al. 2020

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Hyaluronic acid, curcumin, and usnic acid are separately utilized as effective biological agents in medicine, and materials based on its blend are considered to have wider therapeutic effects than individual ones. In this study, for the first time, native hyaluronic acid-based fibers containing curcumin and usnic acid with an average diameter of 298 nm were successfully prepared by the electrospinning technique and characterized. Additionally, unstable and hydrophobic curcumin and usnic acid were loaded into the hydrophilic hyaluronic acid matrix without utilizing the activating (catalyzing) agents, resulting in the formation of an electrospinnable solution. Only the binary mixture deionized water—dimethyl sulfoxide (50:50)—was used as solvent. The presence of small amounts of dimethyl sulfoxide in the fibrous materials was expected to provide the materials with local anesthetic and antiseptic activity. The effect of electric voltage on the electrospinning process, diameter, and morphology of hyaluronic acid/curcumin/usnic acid fibers was investigated in detail. The impact of curcumin and usnic acid on the stability of fiber formation was observed. The investigation of fibers based on pure hyaluronic acid without additional polymers and with active pharmaceutical ingredients will lay the groundwork for the development of highly effective wound dressings and new drug delivery scaffolds.

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Hyaluronic Acid

Cited by 45 publications

References 0 publications

Hyaluronic Acid: The Influence of Molecular Weight on Structural, Physical, Physico-Chemical, and Degradable Properties of Biopolymer

Hyaluronic Acid: The Influence of Molecular Weight on Structural, Physical, Physico-Chemical, and Degradable Properties of Biopolymer

Mucins as multifunctional building blocks of biomaterials

Curcumin/Usnic Acid-Loaded Electrospun Nanofibers Based on Hyaluronic Acid

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